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67. Gullberg E, Cao S, Berg OG et al (2011) Selection of resistant Bacteria at very low antibiotic
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68. Tamtam F, Mercier F, Le Bot B et al (2008) Occurrence and fate of antibiotics in the Seine River
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scitotenv.2007.12.009
69. Thurman EM, Dietze JE, Scribner EA (2002) Occurrence of antibiotics in water from fish
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70. Dinh QT, Moreau-Guigon E, Labadie P et al (2017) Fate of antibiotics from hospital and
domestic sources in a sewage network. Sci Total Environ 575:758–766. https://doi.org/10.1016/
j.scitotenv.2016.09.118
71. Dinh QT, Moreau-Guigon E, Labadie P et al (2017) Occurrence of antibiotics in rural catchments. Chemosphere 168:483–490. https://doi.org/10.1016/j.chemosphere.2016.10.106
72. Rosal R, Rodríguez A, Perdigón-Melón JA et al (2010) Occurrence of emerging pollutants in
urban wastewater and their removal through biological treatment followed by ozonation. Water
Res 44:578–588. https://doi.org/10.1016/j.watres.2009.07.004
73. Gros M, Petrović M, Barceló D (2009) Tracing pharmaceutical residues of different therapeutic
classes in environmental waters by using liquid chromatography/Quadrupole-linear ion trap
mass spectrometry and automated library searching. Anal Chem 81:898–912. https://doi.org/10.
1021/ac801358e
74. Servais P, Passerat J (2009) Antimicrobial resistance of fecal bacteria in waters of the Seine
river watershed (France). Sci Total Environ 408:365–372. https://doi.org/10.1016/j.scitotenv.
2009.09.042
75. Kovac Virsek M, Hubad B, Lapanje A (2013) Mercury induced community tolerance in
microbial biofilms is related to pollution gradients in a long-term polluted river. Aquat Toxicol
144–145:208–217. https://doi.org/10.1016/j.aquatox.2013.09.023
76. Aubertheau E, Stalder T, Mondamert L et al (2017) Impact of wastewater treatment plant
discharge on the contamination of river biofilms by pharmaceuticals and antibiotic resistance.
Sci Total Environ 579:1387–1398. https://doi.org/10.1016/j.scitotenv.2016.11.136
Contaminants of Emerging Concern in the Seine River Basin: Overview of. . .
379
in zebra mussel (Dreissena polymorpha) by real-time PCR: an organotropism study. Environ
Sci Pollut Res 22:13693–13701. https://doi.org/10.1007/s11356-015-4296-y
59. Pond K, Rueedi J, Pedley S (2004) Pathogens in drinking water sources. In: Microbiological
risk assessment: a scientific basis for managing drinking water safety from source to tap. Robens
Centre for Public and Environmental Health, University of Surrey
60. Olson ME, Thorlakson CL, Deselliers L et al (1997) Giardia and Cryptosporidium in Canadian
farm animals. Vet Parasitol 68:375–381. https://doi.org/10.1016/S0304-4017(96)01072-2
61. Smith HV, Rose JB (1990) Waterborne cryptosporidiosis. Parasitol Today 6:8–12. https://doi.
org/10.1016/0169-4758(90)90378-H
62. Ventola CL (2015) The antibiotic resistance crisis: part 1: causes and threats. P T 40:277–283
63. Kümmerer K (2003) Significance of antibiotics in the environment. J Antimicrob Chemother
52:5–7. https://doi.org/10.1093/jac/dkg293
64. Davies J, Spiegelman GB, Yim G (2006) The world of subinhibitory antibiotic concentrations.
Curr Opin Microbiol 9:445–453. https://doi.org/10.1016/j.mib.2006.08.006
65. Kohanski MA, DePristo MA, Collins JJ (2010) Sublethal antibiotic treatment leads to multidrug
resistance via radical-induced mutagenesis. Mol Cell 37:311–320. https://doi.org/10.1016/j.
molcel.2010.01.003
66. Baharoglu Z, Mazel D (2011) Vibrio cholerae triggers SOS and mutagenesis in response to a
wide range of antibiotics: a route towards multiresistance. Antimicrob Agents Chemother
55:2438–2441. https://doi.org/10.1128/AAC.01549-10
67. Gullberg E, Cao S, Berg OG et al (2011) Selection of resistant Bacteria at very low antibiotic
concentrations. PLoS Pathog 7:e1002158. https://doi.org/10.1371/journal.ppat.1002158
68. Tamtam F, Mercier F, Le Bot B et al (2008) Occurrence and fate of antibiotics in the Seine River
in various hydrological conditions. Sci Total Environ 393:84–95. https://doi.org/10.1016/j.
scitotenv.2007.12.009
69. Thurman EM, Dietze JE, Scribner EA (2002) Occurrence of antibiotics in water from fish
hatcheries. U.S. Department of the Interior/U.S. Geological Survey, USGS Fact Sheet 120-02
70. Dinh QT, Moreau-Guigon E, Labadie P et al (2017) Fate of antibiotics from hospital and
domestic sources in a sewage network. Sci Total Environ 575:758–766. https://doi.org/10.1016/
j.scitotenv.2016.09.118
71. Dinh QT, Moreau-Guigon E, Labadie P et al (2017) Occurrence of antibiotics in rural catchments. Chemosphere 168:483–490. https://doi.org/10.1016/j.chemosphere.2016.10.106
72. Rosal R, Rodríguez A, Perdigón-Melón JA et al (2010) Occurrence of emerging pollutants in
urban wastewater and their removal through biological treatment followed by ozonation. Water
Res 44:578–588. https://doi.org/10.1016/j.watres.2009.07.004
73. Gros M, Petrović M, Barceló D (2009) Tracing pharmaceutical residues of different therapeutic
classes in environmental waters by using liquid chromatography/Quadrupole-linear ion trap
mass spectrometry and automated library searching. Anal Chem 81:898–912. https://doi.org/10.
1021/ac801358e
74. Servais P, Passerat J (2009) Antimicrobial resistance of fecal bacteria in waters of the Seine
river watershed (France). Sci Total Environ 408:365–372. https://doi.org/10.1016/j.scitotenv.
2009.09.042
75. Kovac Virsek M, Hubad B, Lapanje A (2013) Mercury induced community tolerance in
microbial biofilms is related to pollution gradients in a long-term polluted river. Aquat Toxicol
144–145:208–217. https://doi.org/10.1016/j.aquatox.2013.09.023
76. Aubertheau E, Stalder T, Mondamert L et al (2017) Impact of wastewater treatment plant
discharge on the contamination of river biofilms by pharmaceuticals and antibiotic resistance.
Sci Total Environ 579:1387–1398. https://doi.org/10.1016/j.scitotenv.2016.11.136
Contaminants of Emerging Concern in the Seine River Basin: Overview of. . .
379