example, in gas–liquid–solid multiphase reactions, continuous-flow systems
employing microchannel and fixed-bed reactors provide high specific interfacial
surface area to afford efficient reaction environments. These continuous-flow reactors possess high compatibility with sequential continuous-flow systems, which
enables multistep flow synthesis of biologically active compounds such as APIs
and natural products. In addition, these continuous-flow systems are easily scaled up
by increasing either the size of the column or the number of reactors. Moreover,
continuous-flow systems can be used to realize unique chemoselectivities that
cannot be achieved in batch reactors, by controlling the residence time of reactants
in the catalyst column.
References
1. Kobayashi S (2016) Chem Asian J 11:425–436
2. Kobayashi S, Miyamura H (2013) Aldrichimica Acta 46:3–19
3. Kobayashi J, Mori Y, Okamoto K, Akiyama R, Ueno M, Kitamori T, Kobayashi S (2004)
Science 304:1305–1308
4. Oyamada H, Akiyama R, Hagio H, Naito T, Kobayashi S (2006) Chem Commun:4297–4299
5. Ueno M, Suzuki T, Naito T, Oyamada H, Kobayashi S (2008) Chem Commun:1647–1649
6. Miyamura H, Matsubara R, Miyazaki Y, Kobayashi S (2007) Angew Chem Int Ed
46:4151–4154
7. Wang N, Matsumoto T, Ueno M, Miyamura H, Kobayashi S (2009) Angew Chem Int Ed
48:4744–4746
8. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Science 285:83
9. Uozumi Y, Yamada YMA, Beppu T, Fukuyama N, Ueno M, Kitamori T (2006) J Am Chem
Soc 128:15994–15995
10. Yamada YM, Watanabe T, Ohno A, Uozumi Y (2012) ChemSusChem 5:293–299
11. Oyamada H, Naito T, Miyamoto S, Akiyama R, Hagio H, Kobayashi S (2008) Org Biomol
Chem 6:61–65
12. Oyamada H, Naito T, Kobayashi S (2011) Beilstein J Org Chem 7:735–739
13. Kobayashi S, Okumura M, Akatsuka Y, Miyamura H, Ueno M, Oyamada H (2015)
ChemCatChem 7:4025–4029
14. Saito Y, Ishitani H, Kobayashi S (2016) Asian J Org Chem 5:1124–1127
15. Ishitani H, Saito Y, Tsubogo T, Kobayashi S (2016) Org Lett 18:1346–1349
16. Saito Y, Ishitani H, Ueno M, Kobayashi S (2017) ChemistryOpen 6:211–215
17. Tsubogo T, Oyamada H, Kobayashi S (2015) Nature 520:329–332
18. Saaby S, Knudsen KR, Ladlow M, Ley SV (2005) Chem Commun:2909–2911
19. Laroche B, Ishitani H, Kobayashi S (2018) Adv Synth Catal 360:4699–4704
20. Irfan M, Petricci E, Glasnov TN, Taddei M, Kappe CO (2009) Eur J Org Chem
2009:1327–1334
21. Ouchi T, Battilocchio C, Hawkins JM, Ley SV (2014) Org Process Res Dev 18:1560–1566
22. Miyamura H, Suzuki A, Yasukawa T, Kobayashi S (2018) J Am Chem Soc 140:11325–11334
23. Zotova N, Hellgardt K, Kelsall GH, Jessiman AS, Hii KK (2010) Green Chem 12:2157
24. Kaizuka K, Miyamura H, Kobayashi S (2010) J Am Chem Soc 132:15096–15098
25. Kaizuka K, Lee K-Y, Miyamura H, Kobayashi S (2012) J Flow Chem 2:1
26. Mannel DS, Ahmed MS, Root TW, Stahl SS (2017) J Am Chem Soc 139:1690–1698
27. Gross E, Liu Jack H-C, Toste FD, Somorjai GA (2012) Nat Chem 4:947–952
Nanoparticle Catalysts in Flow Systems
241
employing microchannel and fixed-bed reactors provide high specific interfacial
surface area to afford efficient reaction environments. These continuous-flow reactors possess high compatibility with sequential continuous-flow systems, which
enables multistep flow synthesis of biologically active compounds such as APIs
and natural products. In addition, these continuous-flow systems are easily scaled up
by increasing either the size of the column or the number of reactors. Moreover,
continuous-flow systems can be used to realize unique chemoselectivities that
cannot be achieved in batch reactors, by controlling the residence time of reactants
in the catalyst column.
References
1. Kobayashi S (2016) Chem Asian J 11:425–436
2. Kobayashi S, Miyamura H (2013) Aldrichimica Acta 46:3–19
3. Kobayashi J, Mori Y, Okamoto K, Akiyama R, Ueno M, Kitamori T, Kobayashi S (2004)
Science 304:1305–1308
4. Oyamada H, Akiyama R, Hagio H, Naito T, Kobayashi S (2006) Chem Commun:4297–4299
5. Ueno M, Suzuki T, Naito T, Oyamada H, Kobayashi S (2008) Chem Commun:1647–1649
6. Miyamura H, Matsubara R, Miyazaki Y, Kobayashi S (2007) Angew Chem Int Ed
46:4151–4154
7. Wang N, Matsumoto T, Ueno M, Miyamura H, Kobayashi S (2009) Angew Chem Int Ed
48:4744–4746
8. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Science 285:83
9. Uozumi Y, Yamada YMA, Beppu T, Fukuyama N, Ueno M, Kitamori T (2006) J Am Chem
Soc 128:15994–15995
10. Yamada YM, Watanabe T, Ohno A, Uozumi Y (2012) ChemSusChem 5:293–299
11. Oyamada H, Naito T, Miyamoto S, Akiyama R, Hagio H, Kobayashi S (2008) Org Biomol
Chem 6:61–65
12. Oyamada H, Naito T, Kobayashi S (2011) Beilstein J Org Chem 7:735–739
13. Kobayashi S, Okumura M, Akatsuka Y, Miyamura H, Ueno M, Oyamada H (2015)
ChemCatChem 7:4025–4029
14. Saito Y, Ishitani H, Kobayashi S (2016) Asian J Org Chem 5:1124–1127
15. Ishitani H, Saito Y, Tsubogo T, Kobayashi S (2016) Org Lett 18:1346–1349
16. Saito Y, Ishitani H, Ueno M, Kobayashi S (2017) ChemistryOpen 6:211–215
17. Tsubogo T, Oyamada H, Kobayashi S (2015) Nature 520:329–332
18. Saaby S, Knudsen KR, Ladlow M, Ley SV (2005) Chem Commun:2909–2911
19. Laroche B, Ishitani H, Kobayashi S (2018) Adv Synth Catal 360:4699–4704
20. Irfan M, Petricci E, Glasnov TN, Taddei M, Kappe CO (2009) Eur J Org Chem
2009:1327–1334
21. Ouchi T, Battilocchio C, Hawkins JM, Ley SV (2014) Org Process Res Dev 18:1560–1566
22. Miyamura H, Suzuki A, Yasukawa T, Kobayashi S (2018) J Am Chem Soc 140:11325–11334
23. Zotova N, Hellgardt K, Kelsall GH, Jessiman AS, Hii KK (2010) Green Chem 12:2157
24. Kaizuka K, Miyamura H, Kobayashi S (2010) J Am Chem Soc 132:15096–15098
25. Kaizuka K, Lee K-Y, Miyamura H, Kobayashi S (2012) J Flow Chem 2:1
26. Mannel DS, Ahmed MS, Root TW, Stahl SS (2017) J Am Chem Soc 139:1690–1698
27. Gross E, Liu Jack H-C, Toste FD, Somorjai GA (2012) Nat Chem 4:947–952
Nanoparticle Catalysts in Flow Systems
241