Gawande et al. reported the use of magnetic CuNPs for various C-heteroatom
bond constructions [56]. Copper was uniformly dispersed on the surface of
maghemite thereby gaining access to new C-O, C-S, and C-N bonds in moderateto-excellent yields despite high temperatures and catalyst loadings (~3–6 mol%).
These NPs could be recovered magnetically, washed with ethanol, dried at 60
C
under vacuum, and then reused six times with unaltered efficiency (Fig. 27).
One-pot, multicomponent reactions (MCRs) are of great industrial importance,
offering expeditious routes toward complicated target molecules, as illustrated
by Ugi [57, 58], Passerini [59], Biginelli [60, 61], and others. The processes
involved usually enjoy the benefits of environmental friendliness, as the number of
downstream processing and purification steps is typically significantly reduced.
Fig. 26 Copper
nanoparticles on walnut
shell for reduction reactions
Fig. 27 C-Heteroatom bond formation with Cu-maghemite NPs
Fig. 25 Sonogashira-like
reaction catalyzed by
CuNPs supported on a
mesoporous polymer
102
M. Cortes-Clerget et al.
bond constructions [56]. Copper was uniformly dispersed on the surface of
maghemite thereby gaining access to new C-O, C-S, and C-N bonds in moderateto-excellent yields despite high temperatures and catalyst loadings (~3–6 mol%).
These NPs could be recovered magnetically, washed with ethanol, dried at 60
C
under vacuum, and then reused six times with unaltered efficiency (Fig. 27).
One-pot, multicomponent reactions (MCRs) are of great industrial importance,
offering expeditious routes toward complicated target molecules, as illustrated
by Ugi [57, 58], Passerini [59], Biginelli [60, 61], and others. The processes
involved usually enjoy the benefits of environmental friendliness, as the number of
downstream processing and purification steps is typically significantly reduced.
Fig. 26 Copper
nanoparticles on walnut
shell for reduction reactions
Fig. 27 C-Heteroatom bond formation with Cu-maghemite NPs
Fig. 25 Sonogashira-like
reaction catalyzed by
CuNPs supported on a
mesoporous polymer
102
M. Cortes-Clerget et al.