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+ channels as targets of insecticides. Trends Pharmacol
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differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica
22:983–991
53. Wang C, Chen F, Zhang Q et al (2009) Chronic toxicity and cytotoxicity of synthetic pyrethroid
insecticide cis-bifenthrin. J Environ Sci (China) 21:1710–1715. https://doi.org/10.1016/s10010742(08)62477-8
54. Ravula AR, Yenugu S (2019) Long term oral administration of a mixture of pyrethroids affects
reproductive function in rats. Reprod Toxicol 89:1–12. https://doi.org/10.1016/j.reprotox.2019.
06.007
55. Wang H, He Y, Cheng D et al (2019) Cypermethrin exposure reduces the ovarian reserve by
causing mitochondrial dysfunction in granulosa cells. Toxicol Appl Pharmacol 379:114693.
https://doi.org/10.1016/j.taap.2019.114693
56. Sun D, Pang J, Zhou Z et al (2016) Enantioselective environmental behavior and cytotoxicity
of chiral acaricide cyflumetofen. Chemosphere 161:167–173. https://doi.org/10.1016/j.
chemosphere.2016.06.087
57. Wang F, Liu D, Qu H et al (2016) A full evaluation for the enantiomeric impacts of lactofen and
its metabolites on aquatic macrophyte Lemna minor. Water Res 101:55–63. https://doi.org/10.
1016/j.watres.2016.05.064
58. Zhao M, Chen F, Wang C et al (2010) Integrative assessment of enantioselectivity in endocrine
disruption and immunotoxicity of synthetic pyrethroids. Environ Pollut 158:1968–1973. https://
doi.org/10.1016/j.envpol.2009.10.027
59. EC – European Commission (2012) Health and consumers > plants > pesticides. http://ec.
europa.eu/food/plant/pesticides/index_en.htm. Accessed Mar 2017
60. DG SANCO – Directorate General for Health and Consumers (2008) EU Pesticides
database.
https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/public/?
event¼homepage&language¼EN. Accessed Nov 2019
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Ò. Aznar-Alemany and E. Eljarrat
(exemplified by pyrethroid poisoning). Gesundheitswesen (Bundesverband der Arzte des
Offentlichen Gesundheitsdienstes (Germany)) 57:214–222
48. Issam C, Zohra H, Monia Z et al (2011) Effects of dermal sub-chronic exposure of pubescent
male rats to permethrin (PRMT) on the histological structures of genital tract, testosterone and
lipoperoxidation. Exp Toxicol Pathol 63:393–400. https://doi.org/10.1016/j.etp.2010.02.016
49. Moshammer H (1996) Comment on Muller-Mohnssen, H., K. Hahn. A method for early
detection of neurotoxic diseases. Gesundheitswesen (Bundesverband der Arzte des
Offentlichen Gesundheitsdienstes (Germany)) 58:47–49
50. Nasterlack M, Chr Dietz M (1996) Comment on Muller-Mohnssen, H., K. Hahn. A method for
early detection of neurotoxic diseases. Gesundheitswesen (Bundesverband der Arzte des
Offentlichen Gesundheitsdienstes (Germany)) 58:49–50
51. Narahashi T (1992) Nerve membrane Na
+ channels as targets of insecticides. Trends Pharmacol
Sci 13:236–241
52. Woollen BH, Marsh JR, Laird WJD et al (1992) The metabolism of cypermethrin in man –
differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica
22:983–991
53. Wang C, Chen F, Zhang Q et al (2009) Chronic toxicity and cytotoxicity of synthetic pyrethroid
insecticide cis-bifenthrin. J Environ Sci (China) 21:1710–1715. https://doi.org/10.1016/s10010742(08)62477-8
54. Ravula AR, Yenugu S (2019) Long term oral administration of a mixture of pyrethroids affects
reproductive function in rats. Reprod Toxicol 89:1–12. https://doi.org/10.1016/j.reprotox.2019.
06.007
55. Wang H, He Y, Cheng D et al (2019) Cypermethrin exposure reduces the ovarian reserve by
causing mitochondrial dysfunction in granulosa cells. Toxicol Appl Pharmacol 379:114693.
https://doi.org/10.1016/j.taap.2019.114693
56. Sun D, Pang J, Zhou Z et al (2016) Enantioselective environmental behavior and cytotoxicity
of chiral acaricide cyflumetofen. Chemosphere 161:167–173. https://doi.org/10.1016/j.
chemosphere.2016.06.087
57. Wang F, Liu D, Qu H et al (2016) A full evaluation for the enantiomeric impacts of lactofen and
its metabolites on aquatic macrophyte Lemna minor. Water Res 101:55–63. https://doi.org/10.
1016/j.watres.2016.05.064
58. Zhao M, Chen F, Wang C et al (2010) Integrative assessment of enantioselectivity in endocrine
disruption and immunotoxicity of synthetic pyrethroids. Environ Pollut 158:1968–1973. https://
doi.org/10.1016/j.envpol.2009.10.027
59. EC – European Commission (2012) Health and consumers > plants > pesticides. http://ec.
europa.eu/food/plant/pesticides/index_en.htm. Accessed Mar 2017
60. DG SANCO – Directorate General for Health and Consumers (2008) EU Pesticides
database.
https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/public/?
event¼homepage&language¼EN. Accessed Nov 2019
16
Ò. Aznar-Alemany and E. Eljarrat