36. Omar TFT, Aris AZ, Yusoff FM, Mustafa S (2019) Risk assessment of pharmaceutically active
compounds (PhACs) in the Klang River estuary, Malaysia. Environ Geochem Hlth 41
(1):211–223
37. Eslami A, Amini MM, Yazdanbakhsh AR, Rastkari N, Mohseni-Bandpei A, Nasseri S et al
(2015) Occurrence of non-steroidal anti-inflammatory drugs in Tehran source water, municipal
and hospital wastewaters, and their ecotoxicological risk assessment. Environ Monit Assess 187
(12):734
38. Hoshina K, Horiyama S, Matsunaga H, Haginaka J (2011) Simultaneous determination of
non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography–tandem
mass spectrometry using molecularly imprinted polymers as a pretreatment column. J
Pharmaceut Biomed 55(5):916–922
39. Paíga P, Delerue-Matos C (2013) Response surface methodology applied to SPE for the
determination of ibuprofen in various types of water samples. J Sep Sci 36(19):3220–3225
40. Ma R, Qu H, Wang B, Wang F, Yu Y, Yu G (2019) Simultaneous enantiomeric analysis of
non-steroidal anti-inflammatory drugs in environment by chiral LC-MS/MS: a pilot study in
Beijing, China. Ecotox Environ Safe 174:83–91
41. Chen H, Li X, Zhu S (2012) Occurrence and distribution of selected pharmaceuticals and
personal care products in aquatic environments: a comparative study of regions in China with
different urbanization levels. Environ Sci Pollut Res 19(6):2381–2389
42. Zuccato E, Castiglioni S, Fanelli R (2005) Identification of the pharmaceuticals for human use
contaminating the Italian aquatic environment. J Hazard Mater 122(3):205–209
43. Omar TFT, Aris AZ, Yusoff FM, Mustafa S (2018) Occurrence, distribution, and sources of
emerging organic contaminants in tropical coastal sediments of anthropogenically impacted
Klang River estuary, Malaysia. Mar Pollut Bull 131:284–293
44. Duan YP, Meng XZ, Wen ZH, Ke RH, Chen L (2013) Multi-phase partitioning, ecological risk
and fate of acidic pharmaceuticals in a wastewater-receiving river: the role of colloids. Sci Total
Environ 447:267–273
45. Lolić A, Paíga P, Santos LH, Ramos S, Correia M, Delerue-Matos C (2015) Assessment of
non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk. Sci Total Environ 508:240–250
46. Paíga P, Lolić A, Hellebuyck F, Santos LH, Correia M, Delerue-Matos C (2015) Development
of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. J Pharm Biomed Anal 106:61–70
47. Caban M, Mioduszewska K, Lukaszewicz P, Migowska N, Stepnowski P, Kwiatkowski M,
Kumirska J (2014) A new silylating reagent – dimethyl(3,3,3-trifluoropropyl)
silyldiethylamine – for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas
chromatography-mass spectrometry analysis. J Chromatogr A 1346:107–116
48. Jiang JJ, Lee CL, Fang MD (2014) Emerging organic contaminants in coastal waters: anthropogenic impact, environmental release and ecological risk. Mar Pollut Bull 85(2):391–399
49. Keil R, Salemme K, Forrest B, Neibauer J, Logsdon M (2011) Differential presence of
anthropogenic compounds dissolved in the marine waters of Puget Sound, WA and Barkley
Sound, BC. Mar Pollut Bull 62(11):2404–2411
50. Weigel S, Berger U, Jensen E, Kallenborn R, Thoresen H, Hühnerfuss H (2004) Determination
of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with
emphasis on ibuprofen and its metabolites. Chemosphere 56(6):583–592
51. Bayen S, Zhang H, Desai MM, Ooi SK, Kelly BC (2013) Occurrence and distribution of
pharmaceutically active and endocrine disrupting compounds in Singapore’s marine environment: influence of hydrodynamics and physical-chemical properties. Environ Pollut 182:1–8
52. Fontes MK, Gusso-Choueri PK, Maranho LA, Abessa DMS, Mazur WA, De Campos BG et al
(2018) A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: a
contribution to characterize the hazard. Water Res 132:361–370
Worldwide Occurrence, Detection, and Fate of Nonsteroidal Anti-inflammatory. . .
81
compounds (PhACs) in the Klang River estuary, Malaysia. Environ Geochem Hlth 41
(1):211–223
37. Eslami A, Amini MM, Yazdanbakhsh AR, Rastkari N, Mohseni-Bandpei A, Nasseri S et al
(2015) Occurrence of non-steroidal anti-inflammatory drugs in Tehran source water, municipal
and hospital wastewaters, and their ecotoxicological risk assessment. Environ Monit Assess 187
(12):734
38. Hoshina K, Horiyama S, Matsunaga H, Haginaka J (2011) Simultaneous determination of
non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography–tandem
mass spectrometry using molecularly imprinted polymers as a pretreatment column. J
Pharmaceut Biomed 55(5):916–922
39. Paíga P, Delerue-Matos C (2013) Response surface methodology applied to SPE for the
determination of ibuprofen in various types of water samples. J Sep Sci 36(19):3220–3225
40. Ma R, Qu H, Wang B, Wang F, Yu Y, Yu G (2019) Simultaneous enantiomeric analysis of
non-steroidal anti-inflammatory drugs in environment by chiral LC-MS/MS: a pilot study in
Beijing, China. Ecotox Environ Safe 174:83–91
41. Chen H, Li X, Zhu S (2012) Occurrence and distribution of selected pharmaceuticals and
personal care products in aquatic environments: a comparative study of regions in China with
different urbanization levels. Environ Sci Pollut Res 19(6):2381–2389
42. Zuccato E, Castiglioni S, Fanelli R (2005) Identification of the pharmaceuticals for human use
contaminating the Italian aquatic environment. J Hazard Mater 122(3):205–209
43. Omar TFT, Aris AZ, Yusoff FM, Mustafa S (2018) Occurrence, distribution, and sources of
emerging organic contaminants in tropical coastal sediments of anthropogenically impacted
Klang River estuary, Malaysia. Mar Pollut Bull 131:284–293
44. Duan YP, Meng XZ, Wen ZH, Ke RH, Chen L (2013) Multi-phase partitioning, ecological risk
and fate of acidic pharmaceuticals in a wastewater-receiving river: the role of colloids. Sci Total
Environ 447:267–273
45. Lolić A, Paíga P, Santos LH, Ramos S, Correia M, Delerue-Matos C (2015) Assessment of
non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk. Sci Total Environ 508:240–250
46. Paíga P, Lolić A, Hellebuyck F, Santos LH, Correia M, Delerue-Matos C (2015) Development
of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. J Pharm Biomed Anal 106:61–70
47. Caban M, Mioduszewska K, Lukaszewicz P, Migowska N, Stepnowski P, Kwiatkowski M,
Kumirska J (2014) A new silylating reagent – dimethyl(3,3,3-trifluoropropyl)
silyldiethylamine – for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas
chromatography-mass spectrometry analysis. J Chromatogr A 1346:107–116
48. Jiang JJ, Lee CL, Fang MD (2014) Emerging organic contaminants in coastal waters: anthropogenic impact, environmental release and ecological risk. Mar Pollut Bull 85(2):391–399
49. Keil R, Salemme K, Forrest B, Neibauer J, Logsdon M (2011) Differential presence of
anthropogenic compounds dissolved in the marine waters of Puget Sound, WA and Barkley
Sound, BC. Mar Pollut Bull 62(11):2404–2411
50. Weigel S, Berger U, Jensen E, Kallenborn R, Thoresen H, Hühnerfuss H (2004) Determination
of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with
emphasis on ibuprofen and its metabolites. Chemosphere 56(6):583–592
51. Bayen S, Zhang H, Desai MM, Ooi SK, Kelly BC (2013) Occurrence and distribution of
pharmaceutically active and endocrine disrupting compounds in Singapore’s marine environment: influence of hydrodynamics and physical-chemical properties. Environ Pollut 182:1–8
52. Fontes MK, Gusso-Choueri PK, Maranho LA, Abessa DMS, Mazur WA, De Campos BG et al
(2018) A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: a
contribution to characterize the hazard. Water Res 132:361–370
Worldwide Occurrence, Detection, and Fate of Nonsteroidal Anti-inflammatory. . .
81