Danio rerio
10, 32, 100, 320, 1,000,
3,200
μg/L
34 d
NOEC (hatching rate, egg development)
! 1,134
μg/L
NOEC (survival and growth)
> 320
< 1,000
μg/L
Memmert et al. [90]
Oncorhynchus
mykiss
3.2, 10, 32, 100, 320,
1,000
μg/L
95 d
BCF
< 10
NOEC (hatching rate, egg development, survival and
growth)
! 1,084
μg/L
Histopathology: minimal lesions in kidney (hyaline
inclusions and single cell necrosis), in the liver
(inflammatory cell foci and enhanced basophilia) and
gills (increasing incidences of focal proliferation)
Memmert et al. [90]
Cyprinus carpio
0.015, 0.03, 1, 3 mg/L
30 d
GST
"
GR, TBARS
#
NOEC
¼ 0.015 mg/L
LOEC: 0.03 mg/L
Stepanova et al. [95]
Danio rerio
1.01, 3.38, 10.13, 15.20
μM 4 d
Developmental abnormalities (shorter body length,
smaller eye, pericardial and body edema, lack of liver
and intestine, muscle degeneration, and abnormal
pigmentation)
Chen et al. [92]
Danio rerio
5, 15, 30, 60 mg/L
28 d
LOEC
¼ 15 mg/L
NOEC
¼ 5 mg/L
No histopathological changes were observed
Praskova et al. [96]
Hoplias
malabaricus
a
0, 0.2, 2.0, 20
μg/kg
6 w
HIS
#
Testosterone levels
#
Liver: SOD
"; LPO and GST
#
Guiloski et al. [97]
Cyprinus carpio
7.098 mg/L
4 d
24 d
HPC in blood
#; HPC in the muscle, gills, and liver
"
LPO in brain
#; LPO in the gills and liver
"
PCC in blood
#; PCC in the gills, brain and liver
"
SOD in blood
#; SOD in the gills and brain
"
CAT in the blood and liver
#; CAT in the muscle, gills,
and brain
"
GPx in the gills and brain
#; GPx in the blood and liver
"
Saucedo-Vence et al.
[98]
(continued)
Introduction and Historical Findings That Focused Nonsteroidal. . .
21
10, 32, 100, 320, 1,000,
3,200
μg/L
34 d
NOEC (hatching rate, egg development)
! 1,134
μg/L
NOEC (survival and growth)
> 320
< 1,000
μg/L
Memmert et al. [90]
Oncorhynchus
mykiss
3.2, 10, 32, 100, 320,
1,000
μg/L
95 d
BCF
< 10
NOEC (hatching rate, egg development, survival and
growth)
! 1,084
μg/L
Histopathology: minimal lesions in kidney (hyaline
inclusions and single cell necrosis), in the liver
(inflammatory cell foci and enhanced basophilia) and
gills (increasing incidences of focal proliferation)
Memmert et al. [90]
Cyprinus carpio
0.015, 0.03, 1, 3 mg/L
30 d
GST
"
GR, TBARS
#
NOEC
¼ 0.015 mg/L
LOEC: 0.03 mg/L
Stepanova et al. [95]
Danio rerio
1.01, 3.38, 10.13, 15.20
μM 4 d
Developmental abnormalities (shorter body length,
smaller eye, pericardial and body edema, lack of liver
and intestine, muscle degeneration, and abnormal
pigmentation)
Chen et al. [92]
Danio rerio
5, 15, 30, 60 mg/L
28 d
LOEC
¼ 15 mg/L
NOEC
¼ 5 mg/L
No histopathological changes were observed
Praskova et al. [96]
Hoplias
malabaricus
a
0, 0.2, 2.0, 20
μg/kg
6 w
HIS
#
Testosterone levels
#
Liver: SOD
"; LPO and GST
#
Guiloski et al. [97]
Cyprinus carpio
7.098 mg/L
4 d
24 d
HPC in blood
#; HPC in the muscle, gills, and liver
"
LPO in brain
#; LPO in the gills and liver
"
PCC in blood
#; PCC in the gills, brain and liver
"
SOD in blood
#; SOD in the gills and brain
"
CAT in the blood and liver
#; CAT in the muscle, gills,
and brain
"
GPx in the gills and brain
#; GPx in the blood and liver
"
Saucedo-Vence et al.
[98]
(continued)
Introduction and Historical Findings That Focused Nonsteroidal. . .
21