15. Santos LH, Araujo AN, Fachini A et al (2010) Ecotoxicological aspects related to the presence
of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45–95
16. Nakatsu Y, Nakagawa F, Higashi S et al (2018) Effect of acetaminophen on osteoblastic
differentiation and migration of MC3T3-E1 cells. Pharmacol Rep 70:29–36
17. Desborough MJR, Keeling DM (2017) The aspirin story - from willow to wonder drug. Br J
Haematol 177:674–683
18. Yeomans ND (2011) Aspirin: old drug, new uses and challenges. J Gastroenterol Hepatol
264:26–431
19. Manrique-Moreno M, Heinbockel L, Suwalsky M et al (2016) Biophysical study of the
non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with
phosphatidylserine bilayer membranes. Biochim Biophys Acta 1858:2123–2131
20. Tasdemir A, Taskiran M, Ayyildiz N et al (2018) Effects of low and high doses of
acetylsalicylic acid on penicillin-induced epileptiform activity. Pharmacol Rep 70(5):885–889
21. Kerola M, Vuolteenaho K, Kosonen O et al (2009) Effects of nimesulide, acetylsalicylic acid,
ibuprofen and nabumetone on cyclooxygenase-1and cyclooxygenase-2-mediated prostanoid
production in healthy volunteers ex vivo. Basic Clin Pharmacol Toxicol 104:17–21
22. Dorsch M, Pokorney S, Birmingham M et al (2019) Oral anticoagulation underused and
aspirin overused for atrial fibrillation with advanced chronic kidney disease status. J Am
Coll Cardiol 73(9):408
23. Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56:387–437
24. Beaumont C, Young GC, Cavalier T et al (2014) Human absorption, distribution, metabolism
and excretion properties of drug molecules: a plethora of approaches. Br J Clin Pharmacol 78
(6):1185–1200
25. Lienert J, Güdel K, Escher BI (2007) Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes. Environ Sci
Technol 41:4471–4478
26. Baselt RC, Cravey RH (1995) Disposition of toxic drugs and chemicals in man, 4th edn. Year
Book Medical Publishers, Chicago, pp 105–107
27. Vijaya BD, Kishore KH, Pandu R et al (2013) Low dose aspirin estimation: an application to a
human pharmacokinetic study. Biomed Chromatogr 27:589–598
28. Goodman Gilman A, Rall TW, Nies AS, Tylor P (eds) (1990) The pharmaceutical basis of
therapeutics, 8th edn. Pergamon Press, New York
29. Richardson ML, Bowron JM (1985) The fate of pharmaceutical chemicals in the aquatic
environment. J Pharm Pharmacol 37:1–12
30. Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water
Res 323:245–3260
31. Schulman LJ, Sargent EV, Naumann BD et al (2002) A human health risk assessment of
pharmaceuticals in the aquatic environment. Human Ecol Risk Assess 8:657–680
32. Philip MJ, Aravind UK, Aravindakumar CT (2018) Emerging contaminants in Indian environmental matrices – a review. Chemosphere 190:307–326
33. Gravel A, Wilson JM, Pedro DFN (2009) Non-steroidal anti-inflammatory drugs disturb the
osmoregulatory, metabolic and cortisol responses associated with seawater exposure in rainbow trout. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 149:481–490
34. van Anholt R, Spanings T, Koven W et al (2003) Effects of acetylsalicylic acid treatment on
thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus).
Am J Physiol Regul Integr Comp Physiol 285:1098–1106
35. Davis DP, Daston GP, Odio MR et al (1996) Maternal reproductive effects of oral salicylic
acid in Sprague-Dawley rats. Toxicol Lett 84(3):135–141
36. Cappon GD, Gupta U, Cook JC et al (2003) Comparison of the developmental toxicity of
aspirin in rabbits when administered throughout organogenesis or during sensitive windows of
development. Birth Defects Res B 68:38–46
Toxicity Assessment of Acetylsalicylic Acid to a Freshwater Fish Cyprinus. . .
211
of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45–95
16. Nakatsu Y, Nakagawa F, Higashi S et al (2018) Effect of acetaminophen on osteoblastic
differentiation and migration of MC3T3-E1 cells. Pharmacol Rep 70:29–36
17. Desborough MJR, Keeling DM (2017) The aspirin story - from willow to wonder drug. Br J
Haematol 177:674–683
18. Yeomans ND (2011) Aspirin: old drug, new uses and challenges. J Gastroenterol Hepatol
264:26–431
19. Manrique-Moreno M, Heinbockel L, Suwalsky M et al (2016) Biophysical study of the
non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with
phosphatidylserine bilayer membranes. Biochim Biophys Acta 1858:2123–2131
20. Tasdemir A, Taskiran M, Ayyildiz N et al (2018) Effects of low and high doses of
acetylsalicylic acid on penicillin-induced epileptiform activity. Pharmacol Rep 70(5):885–889
21. Kerola M, Vuolteenaho K, Kosonen O et al (2009) Effects of nimesulide, acetylsalicylic acid,
ibuprofen and nabumetone on cyclooxygenase-1and cyclooxygenase-2-mediated prostanoid
production in healthy volunteers ex vivo. Basic Clin Pharmacol Toxicol 104:17–21
22. Dorsch M, Pokorney S, Birmingham M et al (2019) Oral anticoagulation underused and
aspirin overused for atrial fibrillation with advanced chronic kidney disease status. J Am
Coll Cardiol 73(9):408
23. Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56:387–437
24. Beaumont C, Young GC, Cavalier T et al (2014) Human absorption, distribution, metabolism
and excretion properties of drug molecules: a plethora of approaches. Br J Clin Pharmacol 78
(6):1185–1200
25. Lienert J, Güdel K, Escher BI (2007) Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes. Environ Sci
Technol 41:4471–4478
26. Baselt RC, Cravey RH (1995) Disposition of toxic drugs and chemicals in man, 4th edn. Year
Book Medical Publishers, Chicago, pp 105–107
27. Vijaya BD, Kishore KH, Pandu R et al (2013) Low dose aspirin estimation: an application to a
human pharmacokinetic study. Biomed Chromatogr 27:589–598
28. Goodman Gilman A, Rall TW, Nies AS, Tylor P (eds) (1990) The pharmaceutical basis of
therapeutics, 8th edn. Pergamon Press, New York
29. Richardson ML, Bowron JM (1985) The fate of pharmaceutical chemicals in the aquatic
environment. J Pharm Pharmacol 37:1–12
30. Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water
Res 323:245–3260
31. Schulman LJ, Sargent EV, Naumann BD et al (2002) A human health risk assessment of
pharmaceuticals in the aquatic environment. Human Ecol Risk Assess 8:657–680
32. Philip MJ, Aravind UK, Aravindakumar CT (2018) Emerging contaminants in Indian environmental matrices – a review. Chemosphere 190:307–326
33. Gravel A, Wilson JM, Pedro DFN (2009) Non-steroidal anti-inflammatory drugs disturb the
osmoregulatory, metabolic and cortisol responses associated with seawater exposure in rainbow trout. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 149:481–490
34. van Anholt R, Spanings T, Koven W et al (2003) Effects of acetylsalicylic acid treatment on
thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus).
Am J Physiol Regul Integr Comp Physiol 285:1098–1106
35. Davis DP, Daston GP, Odio MR et al (1996) Maternal reproductive effects of oral salicylic
acid in Sprague-Dawley rats. Toxicol Lett 84(3):135–141
36. Cappon GD, Gupta U, Cook JC et al (2003) Comparison of the developmental toxicity of
aspirin in rabbits when administered throughout organogenesis or during sensitive windows of
development. Birth Defects Res B 68:38–46
Toxicity Assessment of Acetylsalicylic Acid to a Freshwater Fish Cyprinus. . .
211