92. López-Doval JC, Kukkonen JVK, Rodrigo P, Muñoz I (2012) Effects of indomethacin and
propranolol on Chironomus riparius and Physella (Costatella) acuta. Ecotoxicol Environ Saf
78:110–115
93. Nentwig G (2007) Effects of pharmaceuticals on aquatic invertebrates. Part II: the antidepressant drug fluoxetine. Arch Environ Contam Toxicol 52:163–170
94. Oetken M, Nentwig G, Löffler D, Ternes T, Oehlmann J (2005) Effects of pharmaceuticals on
aquatic invertebrates. Part I. The antiepileptic drug carbamazepine. Arch Environ Contam
Toxicol 49:353–361
95. Sánchez-Argüello P, Fernández C, Tarazona JV (2009) Assessing the effects of fluoxetina on
Physa acuta (Gastropoda, Pulmonata) and Chironomus riparius (Insecta, Diptera) using a
two-species water-sediment test. Sci Total Environ 407:1937–1946
96. Nieto E, Corada-Fernández C, Hampel M, Lara-Martín PA, Sánchez-Argüello P, Blasco J
(2017) Effects of exposure to pharmaceuticals (diclofenac and carbamazepine) spiked sediments in the midge, Chironomus riparius (Diptera, Chironomidae). Sci Total Environ
609:715–723
97. Ebele AJ, Abdallah MAE, Harrad S (2017) Pharmaceuticals and personal care products in the
freshwater aquatic environment. Emerg Contam 3:1–16
98. Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR,
Nichols JW, Russom CL, Schmieder PK, Serrano J, Tietge JE, Villeneuve DL (2010) Adverse
outcome pathways: a conceptual framework to support ecotoxicology research and risk
assessment. Environ Toxicol Chem 29:730–741
99. Hartung T (2009) A toxicology for the 21st century-mapping the road ahead. Toxicol Sci
109:18–23
100. EC (2000) Directive 2000/60/EC of the European Parliament and of the Council of 23 October
2000 establishing a framework for community action in the field of water policy
101. EC (2008) Directive 2008/105/EC of the European Parliament and the Council on environmental quality standards in the field of water policy, amending and subsequently repealing
Council Directives 82/176/EEC, 83/513/EEC,84/156/EEC,84/491/EEC, 86/280/EEC and
amending Directive 2000/60/EC, December 2008
102. OECD 218/219: Sediment-Water Chironomid Toxicity Test Using Spiked Sediment/Spiked
Water
103. OECD 233: Sediment-Water Chironomid Life-Cycle Toxicity Test Using Spiked Water or
Spiked Sediment
104. OECD 235: Chironomus sp., Acute Immobilisation Test
105. OECD (2012) Proposal for a template, and guidance on developing and assessing the
completeness of adverse outcome pathways, Appendix I, Collection of Working Definitions.
http://www.oecd.org/chemicalsafety/testingofchemicals/49963576.pdf
106. Yang G, Chen C, Wang Y et al (2017) Mixture toxicity of four commonly used pesticides at
different effect levels to the epigeic earthworm, Eisenia fetida. Ecotoxicol Environ Saf
142:29–39
Ibuprofen and Diclofenac: Effects on Freshwater and Marine Aquatic Organisms –. . .
189
propranolol on Chironomus riparius and Physella (Costatella) acuta. Ecotoxicol Environ Saf
78:110–115
93. Nentwig G (2007) Effects of pharmaceuticals on aquatic invertebrates. Part II: the antidepressant drug fluoxetine. Arch Environ Contam Toxicol 52:163–170
94. Oetken M, Nentwig G, Löffler D, Ternes T, Oehlmann J (2005) Effects of pharmaceuticals on
aquatic invertebrates. Part I. The antiepileptic drug carbamazepine. Arch Environ Contam
Toxicol 49:353–361
95. Sánchez-Argüello P, Fernández C, Tarazona JV (2009) Assessing the effects of fluoxetina on
Physa acuta (Gastropoda, Pulmonata) and Chironomus riparius (Insecta, Diptera) using a
two-species water-sediment test. Sci Total Environ 407:1937–1946
96. Nieto E, Corada-Fernández C, Hampel M, Lara-Martín PA, Sánchez-Argüello P, Blasco J
(2017) Effects of exposure to pharmaceuticals (diclofenac and carbamazepine) spiked sediments in the midge, Chironomus riparius (Diptera, Chironomidae). Sci Total Environ
609:715–723
97. Ebele AJ, Abdallah MAE, Harrad S (2017) Pharmaceuticals and personal care products in the
freshwater aquatic environment. Emerg Contam 3:1–16
98. Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR,
Nichols JW, Russom CL, Schmieder PK, Serrano J, Tietge JE, Villeneuve DL (2010) Adverse
outcome pathways: a conceptual framework to support ecotoxicology research and risk
assessment. Environ Toxicol Chem 29:730–741
99. Hartung T (2009) A toxicology for the 21st century-mapping the road ahead. Toxicol Sci
109:18–23
100. EC (2000) Directive 2000/60/EC of the European Parliament and of the Council of 23 October
2000 establishing a framework for community action in the field of water policy
101. EC (2008) Directive 2008/105/EC of the European Parliament and the Council on environmental quality standards in the field of water policy, amending and subsequently repealing
Council Directives 82/176/EEC, 83/513/EEC,84/156/EEC,84/491/EEC, 86/280/EEC and
amending Directive 2000/60/EC, December 2008
102. OECD 218/219: Sediment-Water Chironomid Toxicity Test Using Spiked Sediment/Spiked
Water
103. OECD 233: Sediment-Water Chironomid Life-Cycle Toxicity Test Using Spiked Water or
Spiked Sediment
104. OECD 235: Chironomus sp., Acute Immobilisation Test
105. OECD (2012) Proposal for a template, and guidance on developing and assessing the
completeness of adverse outcome pathways, Appendix I, Collection of Working Definitions.
http://www.oecd.org/chemicalsafety/testingofchemicals/49963576.pdf
106. Yang G, Chen C, Wang Y et al (2017) Mixture toxicity of four commonly used pesticides at
different effect levels to the epigeic earthworm, Eisenia fetida. Ecotoxicol Environ Saf
142:29–39
Ibuprofen and Diclofenac: Effects on Freshwater and Marine Aquatic Organisms –. . .
189