Overproduction of ROS is associated with pathogenesis, development, and progression of aging and various diseases (cancer, diabetes, inflammatory, cardiovascular, degenerative illness). Nanocarriers responsive to overexpressed ROS could be
useful drug delivery vectors. Zhang et al. developed biocompatible ROS-responsive
nanoparticles as superior drug delivery vehicles [24]. As shown in Fig. 8,
ROS-responsive β-CD was synthesized by conjugating 4-phenylboronic acid
pinacol ester onto hydroxyl groups. The obtained material was processed into
Fig. 7 Schematic and molecular structures of (PTX-AAP&PTX-CD)@MT ternary supramolecular
assembly. (Adapted with permission from Ref. [23]. Copyright 2018 John Wiley and Sons)
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useful drug delivery vectors. Zhang et al. developed biocompatible ROS-responsive
nanoparticles as superior drug delivery vehicles [24]. As shown in Fig. 8,
ROS-responsive β-CD was synthesized by conjugating 4-phenylboronic acid
pinacol ester onto hydroxyl groups. The obtained material was processed into
Fig. 7 Schematic and molecular structures of (PTX-AAP&PTX-CD)@MT ternary supramolecular
assembly. (Adapted with permission from Ref. [23]. Copyright 2018 John Wiley and Sons)
616
W. Mao and D. Ma