the aid of MRI contrast materials, e.g., superparamagnetic Fe 3 O 4 nanoparticles that
could strongly shorten the spin-spin relaxation (T2) time [35, 36]. To further
improve the MRI contrast effect, Wan et al. prepared one kind of magnetic supramolecular assemblies based on the stearic low molecular weight polyethylenimine
(PEI)-supermagnetic Fe 3 O 4 nanoparticles and minicycle DNA and found that the
assemblies showed highly sensitive MRI effect [36]. In the future, novel magnetic
supramolecular assemblies may be developed for further improvement of MRI
sensitivity and be endowed with more functions.
20.4.5 Magnetofection
Owing to the significance of gene transfer in fundamental biology and biomedicine,
a series of transfer strategies have been developed, such as chemical agent-mediated
transfection (e.g., calcium phosphate, PEI, etc.), lipofection, electrotransformation,
virus-mediated transfection, and so on [37]. Magnetofection is a strong transfection
Fig. 6 Schematic illustration of the AuNR-MitP-MNP&HACD against tumor metastasis and
growth with the aid of NIR [34]. (Copyright 2018 American Association for the Advancement of
Science)
568
Q. Yu et al.
could strongly shorten the spin-spin relaxation (T2) time [35, 36]. To further
improve the MRI contrast effect, Wan et al. prepared one kind of magnetic supramolecular assemblies based on the stearic low molecular weight polyethylenimine
(PEI)-supermagnetic Fe 3 O 4 nanoparticles and minicycle DNA and found that the
assemblies showed highly sensitive MRI effect [36]. In the future, novel magnetic
supramolecular assemblies may be developed for further improvement of MRI
sensitivity and be endowed with more functions.
20.4.5 Magnetofection
Owing to the significance of gene transfer in fundamental biology and biomedicine,
a series of transfer strategies have been developed, such as chemical agent-mediated
transfection (e.g., calcium phosphate, PEI, etc.), lipofection, electrotransformation,
virus-mediated transfection, and so on [37]. Magnetofection is a strong transfection
Fig. 6 Schematic illustration of the AuNR-MitP-MNP&HACD against tumor metastasis and
growth with the aid of NIR [34]. (Copyright 2018 American Association for the Advancement of
Science)
568
Q. Yu et al.