the systemic administration of siRNA to patients with solid cancers using the
synthetic delivery nanoparticles. This work provided evidence of inducing an
RNAi mechanism of action in a human from the delivered siRNA. In a word, this
work demonstrated that RNAi can occur in humans from delivered siRNA by the
synthetic delivery nanoparticles, so that siRNA can be used as a gene-specific
therapeutic by delivery systems.
Besides, compared with Davis’s work, an irregular linear CD polymer was easily
accessible via a reaction of CDs and epichlorohydrin in a sodium hydroxide solution
with toluene in one step (Fig. 6a) [44]. Based on those polymers, Yang et al.
constructed a novel two-photon absorption (TPA) nano-micelle used in tumor tissue
imaging [45]. Afterward, they also constructed a supramolecular nano-micelle based
on TPA fluorescent nanoconjugate of linear CD polymer and two-photon dye with
Fig. 5 Schematic illustration of synthetic delivery nanoparticles [42]
Fig. 6 (a) The synthesis of a class of linear CD polymers [44]. (b) Schematic illustration of the
two-photon absorption (TPA) nano-micelle and its imaging in live cells and tissues [46]. (Reprinted
(adapted) with permission from Ref. [46]. Copyright (2014) American Chemical Society)
19 Construction and Applications of Cyclodextrin Polymers in Biology
543
synthetic delivery nanoparticles. This work provided evidence of inducing an
RNAi mechanism of action in a human from the delivered siRNA. In a word, this
work demonstrated that RNAi can occur in humans from delivered siRNA by the
synthetic delivery nanoparticles, so that siRNA can be used as a gene-specific
therapeutic by delivery systems.
Besides, compared with Davis’s work, an irregular linear CD polymer was easily
accessible via a reaction of CDs and epichlorohydrin in a sodium hydroxide solution
with toluene in one step (Fig. 6a) [44]. Based on those polymers, Yang et al.
constructed a novel two-photon absorption (TPA) nano-micelle used in tumor tissue
imaging [45]. Afterward, they also constructed a supramolecular nano-micelle based
on TPA fluorescent nanoconjugate of linear CD polymer and two-photon dye with
Fig. 5 Schematic illustration of synthetic delivery nanoparticles [42]
Fig. 6 (a) The synthesis of a class of linear CD polymers [44]. (b) Schematic illustration of the
two-photon absorption (TPA) nano-micelle and its imaging in live cells and tissues [46]. (Reprinted
(adapted) with permission from Ref. [46]. Copyright (2014) American Chemical Society)
19 Construction and Applications of Cyclodextrin Polymers in Biology
543