Construction and Applications of
Cyclodextrin Polymers in Biology
19
Yao-Hua Liu, Heng-Yi Zhang, and Yu Liu
Contents
19.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 537
19.2 Linear CD Polymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 539
19.2.1 CD Covalently Linked to the Polymers . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . .. . . . 539
19.2.2 Sliding-Ring Materials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544
19.3 Network CD Polymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 547
19.4 Hyperbranched CD Polymers . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 549
19.5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 553
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 554
19.1 Introduction
Cyclodextrins (CDs), one of the most important hosts in supramolecular chemistry,
is a class of oligosaccharide macrocyclic compounds obtained by the tail-to-end
linkage of D-glucopyranose, found by Villiers in 1891 [1]. Since the glucose units
of CDs are in an untwisted chair conformation, that is, the
4 C 1 conformation, CD
exhibits a truncated cone structure. The primary hydroxyl groups (C-6-OH) of CD
are on one side of the molecule, forming the small mouth end of CD (main surface).
On the other hand, all of the secondary hydroxyl groups (C-2, 3-OH) of CD are at
Y.-H. Liu
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University,
Tianjin, China
H.-Y. Zhang · Y. Liu (*)
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University,
Tianjin, China
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China
e-mail: yuliu@nankai.edu.cn
© Springer Nature Singapore Pte Ltd. 2020
Y. Liu et al. (eds.), Handbook of Macrocyclic Supramolecular Assembly,
https://doi.org/10.1007/978-981-15-2686-2_21
537
Cyclodextrin Polymers in Biology
19
Yao-Hua Liu, Heng-Yi Zhang, and Yu Liu
Contents
19.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 537
19.2 Linear CD Polymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 539
19.2.1 CD Covalently Linked to the Polymers . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . .. . . . 539
19.2.2 Sliding-Ring Materials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 544
19.3 Network CD Polymers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 547
19.4 Hyperbranched CD Polymers . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 549
19.5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 553
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 554
19.1 Introduction
Cyclodextrins (CDs), one of the most important hosts in supramolecular chemistry,
is a class of oligosaccharide macrocyclic compounds obtained by the tail-to-end
linkage of D-glucopyranose, found by Villiers in 1891 [1]. Since the glucose units
of CDs are in an untwisted chair conformation, that is, the
4 C 1 conformation, CD
exhibits a truncated cone structure. The primary hydroxyl groups (C-6-OH) of CD
are on one side of the molecule, forming the small mouth end of CD (main surface).
On the other hand, all of the secondary hydroxyl groups (C-2, 3-OH) of CD are at
Y.-H. Liu
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University,
Tianjin, China
H.-Y. Zhang · Y. Liu (*)
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University,
Tianjin, China
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China
e-mail: yuliu@nankai.edu.cn
© Springer Nature Singapore Pte Ltd. 2020
Y. Liu et al. (eds.), Handbook of Macrocyclic Supramolecular Assembly,
https://doi.org/10.1007/978-981-15-2686-2_21
537