adsorption process, while they validly decompose the adsorbed substance by a
specific catalyst, resulting in the pollutant getting rid of the environment effectively.
Undoubtedly, the steadiness and reproducibility of the fabrication of chemical
sensors and adsorbents should be further explored. And the employment of CD
hybrid inorganic nanomaterials as both chiral sensors for enantiomeric recognition
and chiral receptors for enantioselective separation of small chiral molecular guests
still awaits exploration in the near future.
Furthermore, multifunctional CD hybrid inorganic nanomaterials should be
advocated in nanomedicine, which integrated with diagnostic, imaging, and therapy
into one nanosystem. The diagnostic and imaging played the important role in
reporting the presence and location of the tumor, its status and its response to a
specific treatment. And the synergistic combinations of multiple therapeutic modalities with controlled therapeutic process reduced the side effects and enhanced the
effectiveness of cancer treatment. All of these provide the possibility of precision
therapy. In particular, as we all know, the application of CD hybrid inorganic
nanomaterials in nanomedicine should focus on an in-depth insight into the safety
issues in the further, if starting the clinical trials. The development and commercial
applications in the further should be sufficiently considered the abovementioned
correlative fields.
References
1. Rekharsky MV, Inoue Y (1998) Complexation thermodynamics of cyclodextrins. Chem Rev
98(5):1875–1918
2. Szejtli J (1998) Introduction and general overview of cyclodextrin chemistry. Chem Rev
98(5):1743–1754
3. Khan AR, Forgo P, Stine KJ, D'Souza VT (1998) Methods for selective modifications of
cyclodextrins. Chem Rev 98(5):1977–1996
4. Prochowicz D, Kornowicz A, Lewiński J (2017) Interactions of native cyclodextrins with
metal ions and inorganic nanoparticles: fertile landscape for chemistry and materials science.
Chem Rev 11(7):13461–13501
5. Kasprzak A, Poplawska M (2018) Recent developments in the synthesis and applications of
graphene-family materials functionalized with cyclodextrins. Chem Commun 54(62):8547–8562
6. Zhou J, Yu GC, Huang FH (2017) Supramolecular chemotherapy based on host-guest molecular recognition: a novel strategy in the battle against cancer with a bright future. Chem Soc
Rev 46(22):7021–7053
7. Georgakilas V, Otyepka M, Bourlinos AB, Chandra V, Kim N, Kemp KC, Hobza P, Zboril R,
Kim KS (2012) Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications. Chem Rev 112(11):6156–6214
8. Guo YJ, Guo SJ, Ren JT, Zhai YM, Dong SJ, Wang EK (2010) Cyclodextrin functionalized
graphene nanosheets with high supramolecular recognition capability: synthesis and hostguest inclusion for enhanced electrochemical performance. ACS Nano 4(7):4001–4010
9. Liu JL, Leng XY, Xiao Y, Hu CG, Fu L (2015) 3D nitrogen-doped graphene/β-cyclodextrin:
host-guest interactions for electrochemical sensing. Nanoscale 7(28):11922–11927
10. Guo YJ, Guo SJ, Li J, Wang EK, Dong SJ (2011) Cyclodextrin-graphene hybrid nanosheets as
enhanced sensing platform for ultrasensitive determination of carbendazim. Talanta 84(1):60–64
444
W. Liang and S. Shuang
specific catalyst, resulting in the pollutant getting rid of the environment effectively.
Undoubtedly, the steadiness and reproducibility of the fabrication of chemical
sensors and adsorbents should be further explored. And the employment of CD
hybrid inorganic nanomaterials as both chiral sensors for enantiomeric recognition
and chiral receptors for enantioselective separation of small chiral molecular guests
still awaits exploration in the near future.
Furthermore, multifunctional CD hybrid inorganic nanomaterials should be
advocated in nanomedicine, which integrated with diagnostic, imaging, and therapy
into one nanosystem. The diagnostic and imaging played the important role in
reporting the presence and location of the tumor, its status and its response to a
specific treatment. And the synergistic combinations of multiple therapeutic modalities with controlled therapeutic process reduced the side effects and enhanced the
effectiveness of cancer treatment. All of these provide the possibility of precision
therapy. In particular, as we all know, the application of CD hybrid inorganic
nanomaterials in nanomedicine should focus on an in-depth insight into the safety
issues in the further, if starting the clinical trials. The development and commercial
applications in the further should be sufficiently considered the abovementioned
correlative fields.
References
1. Rekharsky MV, Inoue Y (1998) Complexation thermodynamics of cyclodextrins. Chem Rev
98(5):1875–1918
2. Szejtli J (1998) Introduction and general overview of cyclodextrin chemistry. Chem Rev
98(5):1743–1754
3. Khan AR, Forgo P, Stine KJ, D'Souza VT (1998) Methods for selective modifications of
cyclodextrins. Chem Rev 98(5):1977–1996
4. Prochowicz D, Kornowicz A, Lewiński J (2017) Interactions of native cyclodextrins with
metal ions and inorganic nanoparticles: fertile landscape for chemistry and materials science.
Chem Rev 11(7):13461–13501
5. Kasprzak A, Poplawska M (2018) Recent developments in the synthesis and applications of
graphene-family materials functionalized with cyclodextrins. Chem Commun 54(62):8547–8562
6. Zhou J, Yu GC, Huang FH (2017) Supramolecular chemotherapy based on host-guest molecular recognition: a novel strategy in the battle against cancer with a bright future. Chem Soc
Rev 46(22):7021–7053
7. Georgakilas V, Otyepka M, Bourlinos AB, Chandra V, Kim N, Kemp KC, Hobza P, Zboril R,
Kim KS (2012) Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications. Chem Rev 112(11):6156–6214
8. Guo YJ, Guo SJ, Ren JT, Zhai YM, Dong SJ, Wang EK (2010) Cyclodextrin functionalized
graphene nanosheets with high supramolecular recognition capability: synthesis and hostguest inclusion for enhanced electrochemical performance. ACS Nano 4(7):4001–4010
9. Liu JL, Leng XY, Xiao Y, Hu CG, Fu L (2015) 3D nitrogen-doped graphene/β-cyclodextrin:
host-guest interactions for electrochemical sensing. Nanoscale 7(28):11922–11927
10. Guo YJ, Guo SJ, Li J, Wang EK, Dong SJ (2011) Cyclodextrin-graphene hybrid nanosheets as
enhanced sensing platform for ultrasensitive determination of carbendazim. Talanta 84(1):60–64
444
W. Liang and S. Shuang