the tumor cell, which significantly decreasing the side effects compared to normal
protocols. This result indicated that the drug dosage for cancer treatment can be
significantly reduced by a magnetic field-controlled accurate. Level of drug concentration delivery to a tumor.
Shuang and co-workers constructed a pH-responsive controlled release system
based on β-cyclodextrin-assembled magnetic Fe 3 O 4 nanoparticles (β-CD-MNPs) for
stereoisomeric doxorubicin (DOX) and epirubicin (EPI) delivery [50]. The loading
behaviors of β-CD-MNPs for both DOX and EPI followed multilayer Freundlich
isotherm adsorption, and the loading amounts are 70.27 mg/g (DOX) and
39.46 mg/g (EPI), respectively, owing to the different conformation of inclusion
complexes. The β-CD-MNPs/DOX reveals higher and faster release in vitro and
stronger resolution in cell than that of β-CD-MNPs/EPI. These findings could be
extended to the design of the delivery of other stereoisomeric drugs, which may
afford further guidance for their loading and release in biomedical applications.
15.4 Cyclodextrin-Functionalized Semiconductor Quantum
Dots
Semiconductor quantum dots (QDs) exhibit unique optical and photophysical properties and represent one of the major advances in materials science in the last two
decades. Because of QDs offer some advantages compared with conventional
chromophores, such as broad absorption, narrow emission lines, low
Fig. 7 The illustration of preparation procedures and separation mechanism of β-CD-modified
Fe 3 O 4 nanoparticles for amino acids isomers [57]. (Copyright 2011, Royal Society of Chemistry)
15 Cyclodextrin Hybrid Inorganic Nanocomposites for Molecular Recognition. . .
439
protocols. This result indicated that the drug dosage for cancer treatment can be
significantly reduced by a magnetic field-controlled accurate. Level of drug concentration delivery to a tumor.
Shuang and co-workers constructed a pH-responsive controlled release system
based on β-cyclodextrin-assembled magnetic Fe 3 O 4 nanoparticles (β-CD-MNPs) for
stereoisomeric doxorubicin (DOX) and epirubicin (EPI) delivery [50]. The loading
behaviors of β-CD-MNPs for both DOX and EPI followed multilayer Freundlich
isotherm adsorption, and the loading amounts are 70.27 mg/g (DOX) and
39.46 mg/g (EPI), respectively, owing to the different conformation of inclusion
complexes. The β-CD-MNPs/DOX reveals higher and faster release in vitro and
stronger resolution in cell than that of β-CD-MNPs/EPI. These findings could be
extended to the design of the delivery of other stereoisomeric drugs, which may
afford further guidance for their loading and release in biomedical applications.
15.4 Cyclodextrin-Functionalized Semiconductor Quantum
Dots
Semiconductor quantum dots (QDs) exhibit unique optical and photophysical properties and represent one of the major advances in materials science in the last two
decades. Because of QDs offer some advantages compared with conventional
chromophores, such as broad absorption, narrow emission lines, low
Fig. 7 The illustration of preparation procedures and separation mechanism of β-CD-modified
Fe 3 O 4 nanoparticles for amino acids isomers [57]. (Copyright 2011, Royal Society of Chemistry)
15 Cyclodextrin Hybrid Inorganic Nanocomposites for Molecular Recognition. . .
439