grafted CM-β-CD on the Fe 3 O 4 nanoparticles enhanced the particle adsorption capacity
owing to the strong ability of the multiple hydroxyl and carboxyl groups in CM-β-CD to
adsorb metal ions. Another work revealed that β-CD-Fe 3 S 4 NPs exhibited an enhanced
and selective removal capacity toward Pb(II) in comparison with bare Fe 3 S 4 NPs [56].
This research demonstrated that β-CD-stabilized Fe 3 S 4 NPs can be a potential material
for Pb(II) removal from wastewater. In another two works, the Fe 3 O 4 @CD MCs [66]
and succinyl-β-cyclodextrin-APTES@Fe 2 O 3 [54] were synthesized for the removal of
Eu(III) and U(VI) from aqueous phase, respectively. In comparison to naked MNPs, the
CD-modified MNPs demonstrated a higher adsorption capacity toward Eu(III) and U
(VI), and these two adsorbents exhibit the pH dependence to radionuclides adsorption.
In our recent work, the β-CD-modified Fe 3 O 4 nanoparticles have been synthesized by
layer-by-layer approach and used to adsorb methylene blue in aqueous solution [51]. In
addition, carboxymethyl-β-cyclodextrin polymer-coated Fe 3 O 4 nanoparticles (CDPMNPs) have been used to remove the phenolic pollutants from water [68]. These
researches demonstrated that the CDs and CD polymer-coated Fe 3 O 4 nanoparticles
could be used as the promising adsorbents for the elimination of organic pollutants
from wastewater by magnetic separation technology.
The high surface area of the CD-coated magnetic nanomaterials (CD-MNMs) as
well as their ability to separate with an external magnetic field not only can be
utilized toward the above-discussed water treatment, but also CD-MNMs can act as
the adsorbents for drugs [55] and bioactive species [70, 71] separation. Due to the
CD cavity’s unique hydrophobic character and inherent chirality, chiral separation of
CD-conjugated MNPs for drugs and bioactive species has been widely investigated
[33, 57, 72, 73]. For instance, the β-CD-functionalized Fe 3 O 4 nanospheres have been
provided the ability to chirally discriminate amino acids enantiomers while serving
as magnetic separators for effectively separating the isomers of different amino
acids, especially for the tryptophan (Fig. 7) [57].
15.3.3 Cyclodextrin-Functionalized Magnetic Materials for Drug
Delivery
Magnetic nanoparticles are promising supramolecular chemotherapeutic drug carriers because they can deliver anticancer drugs more selectively to the target site
under the guidance of an external magnetic field and hence abate the lesions in
tissues precisely. The CD-modified iron oxide nanoparticles are attractive drug
carriers by virtue of their biocompatibility, biodegradability, aqueous dispersibility,
and magnetizability. The ability of CD-coated MNPs to function as nanocarriers has
been demonstrated in several cases [50, 74–76].
A size-controllable supramolecular magnetic nanoparticles (SMNPs) have been
prepared by utilizing a supramolecular system based on the host-guest interaction
between β-CD and Ad with magnetic nanoparticles [75]. The DOX encapsulated on
the DOX@SMNPs can be controlled release by quickly generating thermal energy
when applying an external alternative magnetic field (AMF). The approximately
50% of DOX was released by applying an AMF only 2 min and effectively inhibited
438
W. Liang and S. Shuang
owing to the strong ability of the multiple hydroxyl and carboxyl groups in CM-β-CD to
adsorb metal ions. Another work revealed that β-CD-Fe 3 S 4 NPs exhibited an enhanced
and selective removal capacity toward Pb(II) in comparison with bare Fe 3 S 4 NPs [56].
This research demonstrated that β-CD-stabilized Fe 3 S 4 NPs can be a potential material
for Pb(II) removal from wastewater. In another two works, the Fe 3 O 4 @CD MCs [66]
and succinyl-β-cyclodextrin-APTES@Fe 2 O 3 [54] were synthesized for the removal of
Eu(III) and U(VI) from aqueous phase, respectively. In comparison to naked MNPs, the
CD-modified MNPs demonstrated a higher adsorption capacity toward Eu(III) and U
(VI), and these two adsorbents exhibit the pH dependence to radionuclides adsorption.
In our recent work, the β-CD-modified Fe 3 O 4 nanoparticles have been synthesized by
layer-by-layer approach and used to adsorb methylene blue in aqueous solution [51]. In
addition, carboxymethyl-β-cyclodextrin polymer-coated Fe 3 O 4 nanoparticles (CDPMNPs) have been used to remove the phenolic pollutants from water [68]. These
researches demonstrated that the CDs and CD polymer-coated Fe 3 O 4 nanoparticles
could be used as the promising adsorbents for the elimination of organic pollutants
from wastewater by magnetic separation technology.
The high surface area of the CD-coated magnetic nanomaterials (CD-MNMs) as
well as their ability to separate with an external magnetic field not only can be
utilized toward the above-discussed water treatment, but also CD-MNMs can act as
the adsorbents for drugs [55] and bioactive species [70, 71] separation. Due to the
CD cavity’s unique hydrophobic character and inherent chirality, chiral separation of
CD-conjugated MNPs for drugs and bioactive species has been widely investigated
[33, 57, 72, 73]. For instance, the β-CD-functionalized Fe 3 O 4 nanospheres have been
provided the ability to chirally discriminate amino acids enantiomers while serving
as magnetic separators for effectively separating the isomers of different amino
acids, especially for the tryptophan (Fig. 7) [57].
15.3.3 Cyclodextrin-Functionalized Magnetic Materials for Drug
Delivery
Magnetic nanoparticles are promising supramolecular chemotherapeutic drug carriers because they can deliver anticancer drugs more selectively to the target site
under the guidance of an external magnetic field and hence abate the lesions in
tissues precisely. The CD-modified iron oxide nanoparticles are attractive drug
carriers by virtue of their biocompatibility, biodegradability, aqueous dispersibility,
and magnetizability. The ability of CD-coated MNPs to function as nanocarriers has
been demonstrated in several cases [50, 74–76].
A size-controllable supramolecular magnetic nanoparticles (SMNPs) have been
prepared by utilizing a supramolecular system based on the host-guest interaction
between β-CD and Ad with magnetic nanoparticles [75]. The DOX encapsulated on
the DOX@SMNPs can be controlled release by quickly generating thermal energy
when applying an external alternative magnetic field (AMF). The approximately
50% of DOX was released by applying an AMF only 2 min and effectively inhibited
438
W. Liang and S. Shuang