affinity experiment, the sandwich structure CD system was shown to specifically
bind at the membrane of mouse alveolar macrophages [38a].
14.3.2.2 Regioselectively Substituted Cyclodextrin Bisglycoconjugates
Hattori, Yamanoi, and coworkers designed and synthesized a series of
bisglycoconjugates based on perbenzylated β-CD platforms, selectively deprotecting
two benzyl groups at the primary positions A and D to give a diol. Then the two
hydroxyls were substituted by amines connected with saccharide units (β-galactose)
by linkers or spacers to synthesize a series of divalent conjugates. The authors used
doxorubicin as a guest model to evaluate the properties of the bisglycoconjugate
Fig. 5 Concepts of mono-, dual, primary-rim, and primary-and-secondary-rim conjugation to
saccharide ligands [32]
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bind at the membrane of mouse alveolar macrophages [38a].
14.3.2.2 Regioselectively Substituted Cyclodextrin Bisglycoconjugates
Hattori, Yamanoi, and coworkers designed and synthesized a series of
bisglycoconjugates based on perbenzylated β-CD platforms, selectively deprotecting
two benzyl groups at the primary positions A and D to give a diol. Then the two
hydroxyls were substituted by amines connected with saccharide units (β-galactose)
by linkers or spacers to synthesize a series of divalent conjugates. The authors used
doxorubicin as a guest model to evaluate the properties of the bisglycoconjugate
Fig. 5 Concepts of mono-, dual, primary-rim, and primary-and-secondary-rim conjugation to
saccharide ligands [32]
402
J. Liu et al.