the tumor-penetrating peptide with the binding site with pillar[5]arene was introduced to construct the supramolecular polymer-based nano-carriers by host-guest
manner, thus successfully developing it as a new target smart vehicle for efficient
drug delivery.
Huang and coworker synthesized a TPE and bipyridinium derivative modified
brush copolymer (PTPE), which could form the side-chain supramolecular polymer
with biotin-modified pillar[5]arene (P5-PEG-Biotin) due to the inclusion
bipyridinium unit into the cavity of pillar[5]arene (Fig. 23) [40]. Furthermore, this
supramolecular polymer could self-assemble into nanoparticles resulting in the
Fig. 20 Schematic illustration of (a) the strategy for the construction of supramolecular polymersomes and (b) the fabrication of supramolecular polymersomes and their applications in
targeted drug delivery. (Reprinted with permission from Ref. [37]. Copyright © 2014. Royal
Society of Chemistry)
368
X. Wu et al.
manner, thus successfully developing it as a new target smart vehicle for efficient
drug delivery.
Huang and coworker synthesized a TPE and bipyridinium derivative modified
brush copolymer (PTPE), which could form the side-chain supramolecular polymer
with biotin-modified pillar[5]arene (P5-PEG-Biotin) due to the inclusion
bipyridinium unit into the cavity of pillar[5]arene (Fig. 23) [40]. Furthermore, this
supramolecular polymer could self-assemble into nanoparticles resulting in the
Fig. 20 Schematic illustration of (a) the strategy for the construction of supramolecular polymersomes and (b) the fabrication of supramolecular polymersomes and their applications in
targeted drug delivery. (Reprinted with permission from Ref. [37]. Copyright © 2014. Royal
Society of Chemistry)
368
X. Wu et al.