To date, only one water-soluble 2,2
0 -biphen[n]arene (22CBP4) has been reported.
The binding behavior towards two pharmaceutical molecules, palmatine (G39
+
) and
berberine (G40
+
), was also investigated [43]. Fluorescence titration experiments
showed that G39
+ and G40
+ exhibited dramatic fluorescence enhancement of more
than 600 times upon binding with 22CBP4. Particularly, the fluorescence intensity
was strong enough to be readily distinguished by the naked eye (Fig. 10). Although
the two guests have similar structures, the association constant of G40
+ with
Fig. 10 (a) Fluorescence spectra of G39
+ in the absence and presence of 22CBP4 in aqueous
phosphate-buffered solution at pH 7.4. (b) Visible emission of G39
+ and G40
+ samples in the
absence and presence of 22CBP4 under 365 nm. Reproduced from Ref. [43] with permission from
Beilstein J. Org. Chem.
332
B. Li et al.
0 -biphen[n]arene (22CBP4) has been reported.
The binding behavior towards two pharmaceutical molecules, palmatine (G39
+
) and
berberine (G40
+
), was also investigated [43]. Fluorescence titration experiments
showed that G39
+ and G40
+ exhibited dramatic fluorescence enhancement of more
than 600 times upon binding with 22CBP4. Particularly, the fluorescence intensity
was strong enough to be readily distinguished by the naked eye (Fig. 10). Although
the two guests have similar structures, the association constant of G40
+ with
Fig. 10 (a) Fluorescence spectra of G39
+ in the absence and presence of 22CBP4 in aqueous
phosphate-buffered solution at pH 7.4. (b) Visible emission of G39
+ and G40
+ samples in the
absence and presence of 22CBP4 under 365 nm. Reproduced from Ref. [43] with permission from
Beilstein J. Org. Chem.
332
B. Li et al.