40. Schuhle DT, Schatz J, Laurent S, Vander Elst L, Muller RN, Stuart MC, Peters JA (2009)
Calix[4]arenes as molecular platforms for magnetic resonance imaging (MRI) contrast agents.
Chem Eur J 15(13):3290–3296
41. Schuhle DT, Polasek M, Lukes I, Chauvin T, Toth E, Schatz J, Hanefeld U, Stuart MC, Peters
JA (2010) Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene
scaffold: a potential MRI contrast agent. Dalton Trans 39(1):185–191
42. Dsouza RN, Pischel U, Nau WM (2011) Fluorescent dyes and their supramolecular host/guest
complexes with macrocycles in aqueous solution. Chem Rev 111(12):7941–7980
43. Norouzy A, Azizi Z, Nau WM (2015) Indicator displacement assays inside live cells. Angew
Chem Int Ed 54(3):792–795
44. Shulov I, Rodik RV, Arntz Y, Reisch A, Kalchenko VI, Klymchenko AS (2016) Protein-sized
bright fluorogenic nanoparticles based on cross-linked calixarene micelles with cyanine corona.
Angew Chem Int Ed 55(51):15884–15888
45. Peng S, Barba-Bon A, Pan Y-C, Nau WM, Guo D-S, Hennig A (2017) Phosphorylationresponsive membrane transport of peptides. Angew Chem Int Ed 56(49):15742–15745
46. Uttam B, Kandi R, Hussain MA, Rao CP (2018) Fluorescent lower rim 1,3-dibenzooxadiazole
conjugate of calix[4]arene in selective sensing of fluoride in solution and in biological
cells using confocal microscopy. J Organomet Chem 83(19):11850–11859
47. Sreedevi P, Nair JB, Preethanuj P, Jeeja BS, Suresh CH, Maiti KK, Varma RL (2018) Calix[4]
arene based redox sensitive molecular probe for SERS guided recognition of labile iron pool
in tumor cells. Anal Chem 90(12):7148–7153
48. Nag R, Kandi R, Rao CP (2018) Host-guest complexation of a lipoic acid conjugate of calix
[4]arene with pyridinium moiety on gold nanorods for mitochondrial tracking followed
by cytotoxicity in Hela cells under 633 nm laser light. ACS Sustain Chem Eng 6(7):
8882–8890
49. Kajouj S, Marcelis L, Mattiuzzi A, Grassin A, Dufour D, Van Antwerpen P, Boturyn D,
Defrancq E, Surin M, De Winter J, Gerbaux P, Jabin I, Moucheron C (2018) Synthesis and
photophysical studies of a multivalent photoreactive Ru(II)-calix[4]arene complex bearing
RGD-containing cyclopentapeptides. Beilstein J Org Chem 14:1758–1768
50. Anandababu A, Anandan S, Ashokkumar M (2018) A simple discriminating p-tert-butylcalix
[4]arene thiospirolactam rhodamine b based colorimetric and fluorescence sensor for mercury
ion and live cell imaging applications. Chemistry 3(16):4413–4420
51. Lotfi B, Tarlani A, Akbari-Moghaddam P, Mirza-Aghayan M, Peyghan AA, Muzart J,
Zadmard R (2017) Multivalent calix[4]arene-based fluorescent sensor for detecting silver ions
in aqueous media and physiological environment. Biosens Bioelectron 90:290–297
52. Ye H, Yang L, Zhao G, Zhang Y, Ran X, Wu S, Zou S, Xie X, Zhao H, Li C-P (2016) A FRETbased fluorescent approach for labetalol sensing using calix[6]arene functionalized
MnO 2 @graphene as a receptor. RSC Adv 6(83):79350–79360
53. Jin T, Tsuboi S, Komatsuzaki A, Imamura Y, Muranaka Y, Sakata T, Yasuda H (2016)
Enhancement of aqueous stability and fluorescence brightness of indocyanine green using
small calix[4]arene micelles for near-infrared fluorescence imaging. Med Chem Commun
7(4):623–631
54. Cakmak Y, Nalbantoglu T, Durgut T, Akkaya EU (2014) PEGylated calix[4]arene as a
carrier for a Bodipy-based photosensitizer. Tetrahedron Lett 55(2):538–540
55. Eggers PK, Becker T, Melvin MK, Boulos RA, James E, Morellini N, Harvey AR, Dunlop SA,
Fitzgerald M, Stubbs KA, Raston CL (2012) Composite fluorescent vesicles based on ionic and
cationic amphiphilic calix[4]arenes. RSC Adv 2(15):6250–6257
56. Gao J, Li J, Geng W-C, Chen F-Y, Duan X, Zheng Z, Ding D, Guo D-S (2018) Biomarker
displacement activation: a general host-guest strategy for targeted phototheranostics in vivo.
J Am Chem Soc 140(14):4945–4953
57. Geng W-C, Jia S, Zheng Z, Li Z, Ding D, Guo D-S (2019) A noncovalent fluorescence turn-on
strategy for hypoxia imaging. Angew Chem Int Ed 58(8):2377–2381
8 Supramolecular Medicine of Diverse Calixarene Derivatives
227
Calix[4]arenes as molecular platforms for magnetic resonance imaging (MRI) contrast agents.
Chem Eur J 15(13):3290–3296
41. Schuhle DT, Polasek M, Lukes I, Chauvin T, Toth E, Schatz J, Hanefeld U, Stuart MC, Peters
JA (2010) Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene
scaffold: a potential MRI contrast agent. Dalton Trans 39(1):185–191
42. Dsouza RN, Pischel U, Nau WM (2011) Fluorescent dyes and their supramolecular host/guest
complexes with macrocycles in aqueous solution. Chem Rev 111(12):7941–7980
43. Norouzy A, Azizi Z, Nau WM (2015) Indicator displacement assays inside live cells. Angew
Chem Int Ed 54(3):792–795
44. Shulov I, Rodik RV, Arntz Y, Reisch A, Kalchenko VI, Klymchenko AS (2016) Protein-sized
bright fluorogenic nanoparticles based on cross-linked calixarene micelles with cyanine corona.
Angew Chem Int Ed 55(51):15884–15888
45. Peng S, Barba-Bon A, Pan Y-C, Nau WM, Guo D-S, Hennig A (2017) Phosphorylationresponsive membrane transport of peptides. Angew Chem Int Ed 56(49):15742–15745
46. Uttam B, Kandi R, Hussain MA, Rao CP (2018) Fluorescent lower rim 1,3-dibenzooxadiazole
conjugate of calix[4]arene in selective sensing of fluoride in solution and in biological
cells using confocal microscopy. J Organomet Chem 83(19):11850–11859
47. Sreedevi P, Nair JB, Preethanuj P, Jeeja BS, Suresh CH, Maiti KK, Varma RL (2018) Calix[4]
arene based redox sensitive molecular probe for SERS guided recognition of labile iron pool
in tumor cells. Anal Chem 90(12):7148–7153
48. Nag R, Kandi R, Rao CP (2018) Host-guest complexation of a lipoic acid conjugate of calix
[4]arene with pyridinium moiety on gold nanorods for mitochondrial tracking followed
by cytotoxicity in Hela cells under 633 nm laser light. ACS Sustain Chem Eng 6(7):
8882–8890
49. Kajouj S, Marcelis L, Mattiuzzi A, Grassin A, Dufour D, Van Antwerpen P, Boturyn D,
Defrancq E, Surin M, De Winter J, Gerbaux P, Jabin I, Moucheron C (2018) Synthesis and
photophysical studies of a multivalent photoreactive Ru(II)-calix[4]arene complex bearing
RGD-containing cyclopentapeptides. Beilstein J Org Chem 14:1758–1768
50. Anandababu A, Anandan S, Ashokkumar M (2018) A simple discriminating p-tert-butylcalix
[4]arene thiospirolactam rhodamine b based colorimetric and fluorescence sensor for mercury
ion and live cell imaging applications. Chemistry 3(16):4413–4420
51. Lotfi B, Tarlani A, Akbari-Moghaddam P, Mirza-Aghayan M, Peyghan AA, Muzart J,
Zadmard R (2017) Multivalent calix[4]arene-based fluorescent sensor for detecting silver ions
in aqueous media and physiological environment. Biosens Bioelectron 90:290–297
52. Ye H, Yang L, Zhao G, Zhang Y, Ran X, Wu S, Zou S, Xie X, Zhao H, Li C-P (2016) A FRETbased fluorescent approach for labetalol sensing using calix[6]arene functionalized
MnO 2 @graphene as a receptor. RSC Adv 6(83):79350–79360
53. Jin T, Tsuboi S, Komatsuzaki A, Imamura Y, Muranaka Y, Sakata T, Yasuda H (2016)
Enhancement of aqueous stability and fluorescence brightness of indocyanine green using
small calix[4]arene micelles for near-infrared fluorescence imaging. Med Chem Commun
7(4):623–631
54. Cakmak Y, Nalbantoglu T, Durgut T, Akkaya EU (2014) PEGylated calix[4]arene as a
carrier for a Bodipy-based photosensitizer. Tetrahedron Lett 55(2):538–540
55. Eggers PK, Becker T, Melvin MK, Boulos RA, James E, Morellini N, Harvey AR, Dunlop SA,
Fitzgerald M, Stubbs KA, Raston CL (2012) Composite fluorescent vesicles based on ionic and
cationic amphiphilic calix[4]arenes. RSC Adv 2(15):6250–6257
56. Gao J, Li J, Geng W-C, Chen F-Y, Duan X, Zheng Z, Ding D, Guo D-S (2018) Biomarker
displacement activation: a general host-guest strategy for targeted phototheranostics in vivo.
J Am Chem Soc 140(14):4945–4953
57. Geng W-C, Jia S, Zheng Z, Li Z, Ding D, Guo D-S (2019) A noncovalent fluorescence turn-on
strategy for hypoxia imaging. Angew Chem Int Ed 58(8):2377–2381
8 Supramolecular Medicine of Diverse Calixarene Derivatives
227