36
device (Fig. 3) [9, 11]. The donor and receptor compartments are
separated by a single-layer semipermeable membrane. In general,
the studies are performed at room temperature. After fluxes from
various MWCO membranes have been obtained, plots of fluxes
against sampling time (i.e., permeation profiles) are designed. A
negative deviation of permeation profile for Fick’s first law provides quantitative analysis of formation of nano-sized aggregates
that are unable to permeate through a given MWCO semipermeFig. 1 Jacketed (left) and unjacketed (right) Franz diffusion cells consist of donor and receptor compartments
separated by semipermeable membrane
Fig. 2 A 96-well micro-equilibrium dialysis device which places semipermeable membrane between two
Teflon bars to form donor and receptor compartments
Phennapha Saokham and Thorsteinn Loftsson
device (Fig. 3) [9, 11]. The donor and receptor compartments are
separated by a single-layer semipermeable membrane. In general,
the studies are performed at room temperature. After fluxes from
various MWCO membranes have been obtained, plots of fluxes
against sampling time (i.e., permeation profiles) are designed. A
negative deviation of permeation profile for Fick’s first law provides quantitative analysis of formation of nano-sized aggregates
that are unable to permeate through a given MWCO semipermeFig. 1 Jacketed (left) and unjacketed (right) Franz diffusion cells consist of donor and receptor compartments
separated by semipermeable membrane
Fig. 2 A 96-well micro-equilibrium dialysis device which places semipermeable membrane between two
Teflon bars to form donor and receptor compartments
Phennapha Saokham and Thorsteinn Loftsson