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References
1. Pellecchia M, Bertini I, Cowburn D et  al
(2008) Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug
Discov 7(9):738–745
2. Ntountaniotis D (2018) Rational drug design:
methods and protocols. Reactions in NMR
tubes as key weapon in rational drug design.
Methods Mol Biol 1824:417–430. (Springer
Science)
3. Fello IC, Pierattelli R (eds) (2014) Advances
in experimental medicine and biology.
Intrinsically disordered proteins studies by
NMR spectroscopy. Springer International
Publishing, Switzerland
4. Hu H, Katyayan KK, Czeskis BA et al (2017)
Comparison between radioanalysis and 19F
Nuclear Magnetic Resonance spectroscopy in
the determination of mass balance, metabolism, and distribution of pefloxacin. Drug
Metab Dispos 45:399–408
5. Bradley SA, Smitka TA, Russell DJ et al (2015)
Quantitative NMR analysis of complex mixtures using CRAFT (complete reduction to
amplitude frequency table) method. Curr
Metabolomics 3:21–31
6. Barding GA Jr, Salditos R, Larive CK (2012)
Quantitative NMR for bioanalysis and metabolomics. Anal Bioanal Chem 404:1165–1179
7. Holzgrabe U, Deubner R, Schollmayer C et al
(2005) Quantitative NMR spectroscopy—
applications in drug analysis. J Pharm Biomed
Anal 38:806–812
8. Do NM, Olivier MA, Salisbury JJ et al (2011)
Application of quantitative
19
F and
1
H NMR
DPPC
DPPC/irbesartan
80:20
DPPC/2-HP-β-CD
80:20
DPPC/ complex irbesartan-2-HP-β-CD
80:20
DPPC/ complex irbesartan-2-HP-β-CD(added from outside)
80:20
c1’,c1”
x2
C2
C2***
C1***
C1
C3
25
20
N(CH3)3
X4
190
170
150
130
90
80
70
60
50
40
30
20
10 (ppm)
(CH2)*10,(CH2)**10
C15*,C15**
C16*,C16**
C3*,C3**
C14*,C14**
C2*,C2*
C irb 4
C HP 6
70
60
C irb 31
C irb 430
Fig. 4
13
C CP/MAS NMR spectra of five samples recorded at 45 °C
NMR Techniques Applied to Drug: Cyclodextrin Complexation