311
J Phys Chem B 115(19):6180–6192. https://
doi.org/10.1021/jp110371k
2. Sadeghpour A, Rappolt M, Ntountaniotis
D, Chatzigeorgiou P, Viras K, Megariotis
G, Papadopoulos MG, Siapi E, Mali G,
Mavromoustakos T (2015) Comparative study
of interactions of aliskiren and AT 1 receptor
antagonists with lipid bilayers. Biochim Biophys
Acta Biomembr 1848(4):984–994. https://
doi.org/10.1016/j.bbamem.2014.12.004
3. Leonis G, Semidalas EC, Chatzigeorgiou P,
Pollatos E, Semidalas CE, Rappolt M, Viras
K, Mavromoustakos T (2019) Chapter five—
Vinblastine: cholesterol interactions in lipid
bilayers. In: Iglič A, Rappolt M, García-Sáez
AJ (eds) Advances in biomembranes and lipid
self-assembly, vol 29, pp 127–157. https://
doi.org/10.1016/bs.abl.2019.01.008
4. Matsingou
C,
Demetzos
C
(2007)
Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by
bioactive labdanes and correlation to their liposome stability. The role of chemical structure.
Chem Phys Lipids 145:45–62. https://doi.
org/10.1016/j.chemphyslip.2006.10.004
5. Matsingou C, Demetzos C (2007) The perturbing effect of cholesterol on the interaction between labdanes and DPPC bilayers.
Thermochim Acta 452:116–123. https://doi.
org/10.1016/j.tca.2006.10.015
6. Koynova R, Caffrey M (1998) Phases and
phase transitions of the phosphatidylcholines.
Biochim Biophys Acta 1376:91–145. https://
doi.org/10.1016/S0304-4157(98)00006-9
7. Koukoulitsa C, Kyrikou I, Demetzos C,
Mavromoustakos T (2006) The role of the
anticancer drug vinorelbine in lipid bilayers using differential scanning calorimetry
and molecular modeling. Chem Phys Lipids
144:85–95.
https://doi.org/10.1016/j.
chemphyslip.2006.07.002
8. Kyrikou I, Georgopoulos A, Hatziantoniou
S, Mavromoustakos T, Demetzos C (2005) A
comparative study of the effects of cholesterol
and sclareol, a bioactive labdane type diterpene,
on phospholipid bilayers. Chem Phys Lipids
133:125–134. https://doi.org/10.1016/j.
chemphyslip.2004.09.021
9. Demetzos C (2015) Biophysics and thermodynamics: the scientific building blocks of bioinspired drug delivery nano systems. AAPS
Pharm Sci Tech 16(3):491–495. https://doi.
org/10.1208/s12249-015-0321-1
10. Demetzos C (2008) Differential scanning calorimetry (DSC): a tool to study the thermal
behavior of lipid bilayers and liposomal stability. J Liposome Res 18:159–173. https://doi.
org/10.1080/08982100802310261
11. Pippa N, Gardikis K, Pispas S, Demetzos
C (2014) The physicochemical/thermodynamic balance of advanced drug liposomal delivery systems. J Therm Anal Calorim
116(1):99–105. https://doi.org/10.1007/
s10973-013-3406-7
12. Pippa N, Meristoudi A, Pispas S, Demetzos C
(2015) Temperature-dependent drug release
from DPPC:C12H25-PNIPAM-COOH liposomes: control of the drug loading/release by
modulation of the nanocarriers’ components.
Int J Pharm 485(1–2):374–382. https://doi.
org/10.1016/j.ijpharm.2015.03.014
13. Pippa N, Pispas S, Demetzos C (2015)
The metastable phases as modulators of
biophysical behavior of liposomal membranes. The role of biomolecular sculpture
of polymeric guest. J Therm Anal Calorim
120(1):937–945. https://doi.org/10.1007/
s10973-014-4116-5
14. Pippa N, Stellas D, Skandalis A, Pispas S,
Demetzos C, Libera M, Marcinkowski A,
Trzebicka B (2016) Chimeric lipid/block
copolymer nanovesicles: physico- chemical
and biocompatibility evaluation. Eur J Pharm
Biopharm
107:295–309.
https://doi.
org/10.1016/j.ejpb.2016.08.003
15. Pippa N, Chronopoulos DD, Stellas D,
Fernández-Pacheco R, Arenal R, Demetzos
C, Tagmatarchis N (2017) Design and development of multi-walled carbon nanotubeliposome drug delivery platforms. Int J
Pharm
528(1–2):429–439.
https://doi.
org/10.1016/j.ijpharm.2017.06.043
16. Demetzos C, Pippa N (2014) Advanced drug
delivery nanosystems (aDDnSs): a mini-review.
Drug Deliv 21(4):250–257. https://doi.org/
10.3109/10717544.2013.844745
17. Liossi AS, Ntountaniotis D, Kellici TF,
Chatziathanasiadou MV, Megariotis G, Mania
M, Becker-Baldus J, Kriechbaum M, Krajnc
A, Christodoulou E, Glaubitz C, Rappolt
M, Heinz A, Gregor M, Theodorou DN,
Valsami G, Pitsikalis M, Iatrou H, Tzakos
AG, Mavromoustakos T (2017) Exploring
the interactions of irbesartan and irbesartan–
2-hydroxypropyl-β-cyclodextrin
complex
with model membranes. Biochim Biophys
Acta
1859(6):1089–1098.
https://doi.
org/10.1016/j.bbamem.2017.03.003
18. Konstantinidi A, Naziris N, Chountoulesi
M, Kiriakidi S, Sartori S, Kolokouris D,
Amentisch H, Mali G, Ntountaniotis D,
Demetzos C, Mavromoustakos T, Kolocouris
A (2018) Comparative perturbation effects
exerted by the Influenza M2 protein inhibitors amantadine and the spiro[pyrrolidine2,2-adamantane] variant AK13 to membrane
DSC on Liposomes and Bilayers Incorporating Drugs and Biomaterials
J Phys Chem B 115(19):6180–6192. https://
doi.org/10.1021/jp110371k
2. Sadeghpour A, Rappolt M, Ntountaniotis
D, Chatzigeorgiou P, Viras K, Megariotis
G, Papadopoulos MG, Siapi E, Mali G,
Mavromoustakos T (2015) Comparative study
of interactions of aliskiren and AT 1 receptor
antagonists with lipid bilayers. Biochim Biophys
Acta Biomembr 1848(4):984–994. https://
doi.org/10.1016/j.bbamem.2014.12.004
3. Leonis G, Semidalas EC, Chatzigeorgiou P,
Pollatos E, Semidalas CE, Rappolt M, Viras
K, Mavromoustakos T (2019) Chapter five—
Vinblastine: cholesterol interactions in lipid
bilayers. In: Iglič A, Rappolt M, García-Sáez
AJ (eds) Advances in biomembranes and lipid
self-assembly, vol 29, pp 127–157. https://
doi.org/10.1016/bs.abl.2019.01.008
4. Matsingou
C,
Demetzos
C
(2007)
Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by
bioactive labdanes and correlation to their liposome stability. The role of chemical structure.
Chem Phys Lipids 145:45–62. https://doi.
org/10.1016/j.chemphyslip.2006.10.004
5. Matsingou C, Demetzos C (2007) The perturbing effect of cholesterol on the interaction between labdanes and DPPC bilayers.
Thermochim Acta 452:116–123. https://doi.
org/10.1016/j.tca.2006.10.015
6. Koynova R, Caffrey M (1998) Phases and
phase transitions of the phosphatidylcholines.
Biochim Biophys Acta 1376:91–145. https://
doi.org/10.1016/S0304-4157(98)00006-9
7. Koukoulitsa C, Kyrikou I, Demetzos C,
Mavromoustakos T (2006) The role of the
anticancer drug vinorelbine in lipid bilayers using differential scanning calorimetry
and molecular modeling. Chem Phys Lipids
144:85–95.
https://doi.org/10.1016/j.
chemphyslip.2006.07.002
8. Kyrikou I, Georgopoulos A, Hatziantoniou
S, Mavromoustakos T, Demetzos C (2005) A
comparative study of the effects of cholesterol
and sclareol, a bioactive labdane type diterpene,
on phospholipid bilayers. Chem Phys Lipids
133:125–134. https://doi.org/10.1016/j.
chemphyslip.2004.09.021
9. Demetzos C (2015) Biophysics and thermodynamics: the scientific building blocks of bioinspired drug delivery nano systems. AAPS
Pharm Sci Tech 16(3):491–495. https://doi.
org/10.1208/s12249-015-0321-1
10. Demetzos C (2008) Differential scanning calorimetry (DSC): a tool to study the thermal
behavior of lipid bilayers and liposomal stability. J Liposome Res 18:159–173. https://doi.
org/10.1080/08982100802310261
11. Pippa N, Gardikis K, Pispas S, Demetzos
C (2014) The physicochemical/thermodynamic balance of advanced drug liposomal delivery systems. J Therm Anal Calorim
116(1):99–105. https://doi.org/10.1007/
s10973-013-3406-7
12. Pippa N, Meristoudi A, Pispas S, Demetzos C
(2015) Temperature-dependent drug release
from DPPC:C12H25-PNIPAM-COOH liposomes: control of the drug loading/release by
modulation of the nanocarriers’ components.
Int J Pharm 485(1–2):374–382. https://doi.
org/10.1016/j.ijpharm.2015.03.014
13. Pippa N, Pispas S, Demetzos C (2015)
The metastable phases as modulators of
biophysical behavior of liposomal membranes. The role of biomolecular sculpture
of polymeric guest. J Therm Anal Calorim
120(1):937–945. https://doi.org/10.1007/
s10973-014-4116-5
14. Pippa N, Stellas D, Skandalis A, Pispas S,
Demetzos C, Libera M, Marcinkowski A,
Trzebicka B (2016) Chimeric lipid/block
copolymer nanovesicles: physico- chemical
and biocompatibility evaluation. Eur J Pharm
Biopharm
107:295–309.
https://doi.
org/10.1016/j.ejpb.2016.08.003
15. Pippa N, Chronopoulos DD, Stellas D,
Fernández-Pacheco R, Arenal R, Demetzos
C, Tagmatarchis N (2017) Design and development of multi-walled carbon nanotubeliposome drug delivery platforms. Int J
Pharm
528(1–2):429–439.
https://doi.
org/10.1016/j.ijpharm.2017.06.043
16. Demetzos C, Pippa N (2014) Advanced drug
delivery nanosystems (aDDnSs): a mini-review.
Drug Deliv 21(4):250–257. https://doi.org/
10.3109/10717544.2013.844745
17. Liossi AS, Ntountaniotis D, Kellici TF,
Chatziathanasiadou MV, Megariotis G, Mania
M, Becker-Baldus J, Kriechbaum M, Krajnc
A, Christodoulou E, Glaubitz C, Rappolt
M, Heinz A, Gregor M, Theodorou DN,
Valsami G, Pitsikalis M, Iatrou H, Tzakos
AG, Mavromoustakos T (2017) Exploring
the interactions of irbesartan and irbesartan–
2-hydroxypropyl-β-cyclodextrin
complex
with model membranes. Biochim Biophys
Acta
1859(6):1089–1098.
https://doi.
org/10.1016/j.bbamem.2017.03.003
18. Konstantinidi A, Naziris N, Chountoulesi
M, Kiriakidi S, Sartori S, Kolokouris D,
Amentisch H, Mali G, Ntountaniotis D,
Demetzos C, Mavromoustakos T, Kolocouris
A (2018) Comparative perturbation effects
exerted by the Influenza M2 protein inhibitors amantadine and the spiro[pyrrolidine2,2-adamantane] variant AK13 to membrane
DSC on Liposomes and Bilayers Incorporating Drugs and Biomaterials