271
(GERD), gastric and duodenal ulcers, and Zollinger–Ellison syndrome [92]. Physicochemical investigation and comparative characterization of nanosuspensions of lansoprazole complexed with
β-CD and β-CD-based NS were performed. Inclusion complexes
of lansoprazole with β-CD and NS were prepared by physical
method and polymer condensation method as shown below
(Fig. 7) [93].
β-CD-based NS and nanosuspensions complexed efficiently
with lansoprazole, thus improving its solubility and stability. The
solubilization efficiency of pyromellitate bridged β-CD NS was
more than 40% compared to CD nanosuspensions. This nanosuspension displayed a high encapsulation efficiency and stability protecting the drug from acidic degradation in stomach, a promising
carrier for nanoparticulate drug delivery in gastric ulcer.
Gases play an important role in medicine, either for diagnostic or
for treatment purposes. It is sometime difficult to deliver oxygen in
appropriate form and dosage in clinical practice. The deficiency of
adequate oxygen supply, named hypoxia, is related to various
pathologies, from inflammation to cancer. The design of delivery
systems providing oxygen for these cases is therefore necessary.
CDs can store gases in their cavity via molecular encapsulation.
The amount of gas complexation varies generally between 0.3 and
1.2 mol gas/mole β-CD. Cross-linked NSs denote superior complexation abilities toward many molecules in comparison with pristine β-CD and preliminary results on complexation abilities of NS
in respect to 1-methylcyclopropene, carbon dioxide, and oxygen
were reported [94].
The ability of NS to reversibly bind compounds, even in the
gas phase, through physisorption mechanisms, might lead to the
development of a new technology for the efficient storage of significant amounts of gas in surprisingly small volumes, without the
need for high pressure and low temperatures, thus avoiding the
risks and energy loss associated with the current use of compressed
or liquefied gases [95].
Nanosponges might be a suitable carrier for oxygen topical
delivery. The application of US on NS aqueous suspension produced an oxygen permeation increase of about 192 ± 2% after
15 min with an initial peak of the gas permeated. The topical application was improved through a new formulation using the combination of oxygen-encapsulating NS and Pluronic F127 hydrogel
was developed. The presence of US increases the oxygen release of
89.7 ± 2% after 30 min. The NS gel formed a regular sustained
oxygen release in the presence and absence of US and acted as
oxygen reservoir [96].
Improved nanosponge formulations for oxygen delivery were
developed. For this purpose, native α-CD, a soluble α-CD polymer, and an insoluble α-CD NS were studied for the in vitro oxy2.14 Cyclodextrin
Nanosponges for Gas
Delivery
Drug-Encapsulated Cyclodextrin Nanosponges
(GERD), gastric and duodenal ulcers, and Zollinger–Ellison syndrome [92]. Physicochemical investigation and comparative characterization of nanosuspensions of lansoprazole complexed with
β-CD and β-CD-based NS were performed. Inclusion complexes
of lansoprazole with β-CD and NS were prepared by physical
method and polymer condensation method as shown below
(Fig. 7) [93].
β-CD-based NS and nanosuspensions complexed efficiently
with lansoprazole, thus improving its solubility and stability. The
solubilization efficiency of pyromellitate bridged β-CD NS was
more than 40% compared to CD nanosuspensions. This nanosuspension displayed a high encapsulation efficiency and stability protecting the drug from acidic degradation in stomach, a promising
carrier for nanoparticulate drug delivery in gastric ulcer.
Gases play an important role in medicine, either for diagnostic or
for treatment purposes. It is sometime difficult to deliver oxygen in
appropriate form and dosage in clinical practice. The deficiency of
adequate oxygen supply, named hypoxia, is related to various
pathologies, from inflammation to cancer. The design of delivery
systems providing oxygen for these cases is therefore necessary.
CDs can store gases in their cavity via molecular encapsulation.
The amount of gas complexation varies generally between 0.3 and
1.2 mol gas/mole β-CD. Cross-linked NSs denote superior complexation abilities toward many molecules in comparison with pristine β-CD and preliminary results on complexation abilities of NS
in respect to 1-methylcyclopropene, carbon dioxide, and oxygen
were reported [94].
The ability of NS to reversibly bind compounds, even in the
gas phase, through physisorption mechanisms, might lead to the
development of a new technology for the efficient storage of significant amounts of gas in surprisingly small volumes, without the
need for high pressure and low temperatures, thus avoiding the
risks and energy loss associated with the current use of compressed
or liquefied gases [95].
Nanosponges might be a suitable carrier for oxygen topical
delivery. The application of US on NS aqueous suspension produced an oxygen permeation increase of about 192 ± 2% after
15 min with an initial peak of the gas permeated. The topical application was improved through a new formulation using the combination of oxygen-encapsulating NS and Pluronic F127 hydrogel
was developed. The presence of US increases the oxygen release of
89.7 ± 2% after 30 min. The NS gel formed a regular sustained
oxygen release in the presence and absence of US and acted as
oxygen reservoir [96].
Improved nanosponge formulations for oxygen delivery were
developed. For this purpose, native α-CD, a soluble α-CD polymer, and an insoluble α-CD NS were studied for the in vitro oxy2.14 Cyclodextrin
Nanosponges for Gas
Delivery
Drug-Encapsulated Cyclodextrin Nanosponges