257
o
o
o
o
o
o
+ HO
+
S S
S
S
OH
β-Cyclodextrin
2-Hydroxy ethyl
disulphide
RT,
TEA
Pyromellitic dianhydride
o
o
o
o
o
o o
o
o
o
o
o
o
o
o
o
o
o
o
GHS-NS
HO
HO
OH
OH
OH
OH
βCD
βCD
Tumor
Lungs
Erlotinib GHS-NS
Drug release
NS reached at
tumor site
Tumor plasma membrane
Inhibits DNA synthesis
and cell profileration
Nucleus
Cyctoplasm
Fig. 2 Schematic diagram of ETB-GHS-NS synthesis, release, and its activity on tumor cells [2]
Drug-Encapsulated Cyclodextrin Nanosponges