232
sample and measure its properties, but those might affect the
measurement quality.
28. The CONTIN method is appropriate for the analysis of polydisperse systems.
29. The samples are exposed to a temperature value that exceeds
the transition temperature of the thermoresponsive functional
phase.
30. The equilibration of samples back to room temperature is necessary to evaluate the final effect of the thermoresponsive
polymer on the liposomal membrane.
Acknowledgments
The research work was supported by the Hellenic Foundation for
Research and Innovation (HFRI) and the General Secretariat for
Research and Technology (GSRT), under the HFRI PhD
Fellowship grant (GA. no. 392).
This work has been co-financed by the European Union and
Greek national funds through the program “Support for
Researchers with Emphasis on Young Researchers” (call code:
EDBM34, ΚΕ 14995) and under the research title “Preparation
and study of innovative forms of administration of pharmaceutical
molecules targeting at improved pharmacological properties.”
References
1. Sánchez-Moreno P, de Vicente J, Nardecchia
S et al (2018) Thermo-sensitive nanomaterials: recent advance in synthesis and biomedical
applications. Nanomaterials (Basel) 8:935–966
2. Demetzos C, Pippa N (2014) Advanced drug
delivery nanosystems (aDDnSs): a mini-review.
Drug Deliv 21:250–257
3. Naziris N, Pippa N, Pispas S et al (2016)
Stimuli-responsive drug delivery nanosystems:
from bench to clinic. Curr Nanomed 6:1–20
4. Lee Y, Thompson DH (2017) Stimuliresponsive liposomes for drug delivery. Wiley
Interdiscip Rev Nanomed Nanobiotechnol
9(5):e1450
5. Lee SM, Nguyen ST (2013) Smart nanoscale
drug delivery platforms from stimuli- responsive
polymers and liposomes. Macromolecules
46:9169–9180
6. Futscher MH, Philipp M, Müller-Buschbaum
P et al (2017) The role of backbone hydration
of poly(n-isopropyl acrylamide) across the volume phase transition compared to its monomer. Sci Rep 7:17012–11731
7. Liu R, Fraylich M, Saunders BR (2009)
Thermoresponsive copolymers: from fundamental studies to applications. Colloid Polym
Sci 287:627–643
8. Lanzalaco S, Armelin E (2017) Poly(nisopropylacrylamide) and copolymers: a review
on recent progresses in biomedical applications. Gels 3:36–67
9. Pippa N, Meristoudi A, Pispas S et al (2015)
Temperature-dependent drug release from
DPPC:C12H25-PNIPAM-COOH liposomes:
control of the drug loading/release by modulation of the nanocarriers’ components. Int J
Pharm 485:374–382
10. Chountoulesi M, Kyrili A, Pippa N et al (2017)
The modulation of physicochemical characterization of innovative liposomal platforms: the
role of the grafted thermoresponsive polymers.
Pharm Dev Technol 22:330–335
11. Naziris N, Pippa N, Pispas S et al (2017) The
thermal analysis of liposomal formulations as
an element to evaluate their effectiveness as
drug and vaccine delivery systems. In: Pearson
Nikolaos Naziris et al.
sample and measure its properties, but those might affect the
measurement quality.
28. The CONTIN method is appropriate for the analysis of polydisperse systems.
29. The samples are exposed to a temperature value that exceeds
the transition temperature of the thermoresponsive functional
phase.
30. The equilibration of samples back to room temperature is necessary to evaluate the final effect of the thermoresponsive
polymer on the liposomal membrane.
Acknowledgments
The research work was supported by the Hellenic Foundation for
Research and Innovation (HFRI) and the General Secretariat for
Research and Technology (GSRT), under the HFRI PhD
Fellowship grant (GA. no. 392).
This work has been co-financed by the European Union and
Greek national funds through the program “Support for
Researchers with Emphasis on Young Researchers” (call code:
EDBM34, ΚΕ 14995) and under the research title “Preparation
and study of innovative forms of administration of pharmaceutical
molecules targeting at improved pharmacological properties.”
References
1. Sánchez-Moreno P, de Vicente J, Nardecchia
S et al (2018) Thermo-sensitive nanomaterials: recent advance in synthesis and biomedical
applications. Nanomaterials (Basel) 8:935–966
2. Demetzos C, Pippa N (2014) Advanced drug
delivery nanosystems (aDDnSs): a mini-review.
Drug Deliv 21:250–257
3. Naziris N, Pippa N, Pispas S et al (2016)
Stimuli-responsive drug delivery nanosystems:
from bench to clinic. Curr Nanomed 6:1–20
4. Lee Y, Thompson DH (2017) Stimuliresponsive liposomes for drug delivery. Wiley
Interdiscip Rev Nanomed Nanobiotechnol
9(5):e1450
5. Lee SM, Nguyen ST (2013) Smart nanoscale
drug delivery platforms from stimuli- responsive
polymers and liposomes. Macromolecules
46:9169–9180
6. Futscher MH, Philipp M, Müller-Buschbaum
P et al (2017) The role of backbone hydration
of poly(n-isopropyl acrylamide) across the volume phase transition compared to its monomer. Sci Rep 7:17012–11731
7. Liu R, Fraylich M, Saunders BR (2009)
Thermoresponsive copolymers: from fundamental studies to applications. Colloid Polym
Sci 287:627–643
8. Lanzalaco S, Armelin E (2017) Poly(nisopropylacrylamide) and copolymers: a review
on recent progresses in biomedical applications. Gels 3:36–67
9. Pippa N, Meristoudi A, Pispas S et al (2015)
Temperature-dependent drug release from
DPPC:C12H25-PNIPAM-COOH liposomes:
control of the drug loading/release by modulation of the nanocarriers’ components. Int J
Pharm 485:374–382
10. Chountoulesi M, Kyrili A, Pippa N et al (2017)
The modulation of physicochemical characterization of innovative liposomal platforms: the
role of the grafted thermoresponsive polymers.
Pharm Dev Technol 22:330–335
11. Naziris N, Pippa N, Pispas S et al (2017) The
thermal analysis of liposomal formulations as
an element to evaluate their effectiveness as
drug and vaccine delivery systems. In: Pearson
Nikolaos Naziris et al.