219
an historical overview of the drug discovery
approaches. Nat Prod Res 32(16):1926–1950
31. Saied EM, Arenz C (2014) Small molecule
inhibitors of ceramidases. Cell Physiol Biochem
34(1):197–212
32. Cho SM, Lee HK, Liu Q, Wang M-W, Kwon
HJ (2018) A guanidine-based synthetic compound suppresses angiogenesis via inhibition of
acid ceramidase. ACS Chem Biol 14(1):11–19
33. Draper JM, Xia Z, Smith RA, Zhuang Y, Wang
W, Smith CD (2011) Discovery and evaluation
of inhibitors of human ceramidase. Mol Cancer
Ther 10(11):2052–2061
34. Vethakanraj HS, Babu TA, Sudarsanan GB,
Duraisamy PK, Kumar SA (2015) Targeting
ceramide metabolic pathway induces apoptosis in human breast cancer cell lines. Biochem
Biophys Res Commun 464(3):833–839
35. Kutlu, Hatice Mehtap, Gokhan KUS Use of
ceranib-2 in the treatment of lung cancer and
breast cancer. U.S. Patent Application 15/899,
520, filed August 23, 2018
36. Voelkel-Johnson C, Norris JS, WhiteGilbertson S (2018) Interdiction of sphingolipid metabolism revisited: Focus on prostate
cancer. Adv Cancer Res 140:265–293
37. Vethakanraj HS, Aslan M, Jayashree A, Priya
PV, Sekar AK (2018) Targeting ceramidase and
sphingosine kinase 1 of ceramide metabolic
pathway induces apoptosis in human colon
cancer cells. Int J Cell Sci Biotechnol 7:23–27.
https://doi.org/10.14741/ijcsb/v.7.3
38. Vejselova D (2016) Hatice Mehtap Kutlu,
and Gökhan Kuş. Examining impacts of ceranib- 2 on the proliferation, morphology and
ultrastructure of human breast cancer cells.
Cytotechnology 68(6):2721–2728
39. Nguyen H, Awad A, Shabani S, Doan N (2018)
Molecular targeting of acid ceramidase in glioblastoma: a review of its role, potential treatment, and challenges. Pharmaceutics 10(2):45
40. Mostafavi E, Soltantabar P, Webster TJ
(2019) Nanotechnology and picotechnology: a new arena for translational medicine. In: Biomaterials in translational
medicine. Academic Press, Cambridge, MA,
pp 191–212
41. Tabassum N, Verma V, Kumar M, Kumar A,
Singh B (2018) Nanomedicine in cancer stem
cell therapy: from fringe to forefront. Cell
Tissue Res 374(3):427–438
42. Tyagi
P,
Subramony
JA
(2018)
Nanotherapeutics in oral and parenteral drug
delivery: key learnings and future outlooks as
we think small. J Controlled Rel 272:159–168
43. Lim E-K, Chung BH, Chung SJ (2018) Recent
advances in pH-sensitive polymeric nanoparticles for smart drug delivery in cancer therapy.
Curr Drug Targets 19(4):300–317
44. Tamjidi F, Shahedi M, Varshosaz J, Nasirpour
A (2013) Nanostructured lipid carriers (NLC):
a potential delivery system for bioactive food
molecules. Innovative Food Sci Emerg Technol
19:29–43
45. Hughes GA (2017) Nanostructure-mediated
drug delivery. In: Nanomedicine in cancer. Pan
Stanford, Singapore, pp 47–72
46. Liu J, Huang Y, Kumar A, Tan A, Jin S, Mozhi
A, Liang X-J (2014) pH-sensitive nano-systems
for drug delivery in cancer therapy. Biotechnol
Adv 32(4):693–710
47. Nitta S, Numata K (2013) Biopolymer-based
nanoparticles for drug/gene delivery and tissue
engineering. Int J Mol Sci 14(1):1629–1654
48. Doppalapudi S, Jain A, Khan W, Domb AJ
(2014) Biodegradable polymers—an overview.
Polym Adv Technol 25(5):427–435
49. Liu D, Yang F, Xiong F, Ning G (2016) The
smart drug delivery system and its clinical
potential. Theranostics 6(9):1306
50. Mitragotri S, Burke PA, Langer R (2014)
Overcoming the challenges in administering
biopharmaceuticals: formulation and delivery
strategies. Nat Rev Drug Discov 13(9):655
51. Katouzian I, Jafari SM (2016) Nanoencapsulation as a promising approach for
targeted delivery and controlled release of vitamins. Trends Food Sci Technol 53:34–48
52. Frank LA, Contri RV, Beck CR, Pohlmann AR,
Guterres SS (2015) Improving drug biological
effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip Rev Nanomed
Nanobiotechnol 7(5):623–639
53. Masarudin MJ, Cutts SM, Evison BJ, Phillips
DR, Pigram PJ (2015) Factors determining the stability, size distribution, and cellular
accumulation of small, monodisperse chitosan
nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin.
Nanotechnol Sci Appl 8:67
54. dos Santos PP, Flôres SH, de Oliveira Rios A,
Chiste RC (2016) Biodegradable polymers as
wall materials to the synthesis of bioactive compound nanocapsules. Trends Food Sci Technol
53:23–33
55. Tang Z, He C, Tian H, Ding J, Hsiao BS, Chu
B, Chen X (2016) Polymeric nanostructured
materials for biomedical applications. Progr
Polym Sci 60:86–128
56. Kulkarni Vishakha SD, Kishor B, Sudha SR
(2012) Natural polymers—A comprehensive review. Int J Res Pharm Biomed Sci
3(4):1597–1613
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters
an historical overview of the drug discovery
approaches. Nat Prod Res 32(16):1926–1950
31. Saied EM, Arenz C (2014) Small molecule
inhibitors of ceramidases. Cell Physiol Biochem
34(1):197–212
32. Cho SM, Lee HK, Liu Q, Wang M-W, Kwon
HJ (2018) A guanidine-based synthetic compound suppresses angiogenesis via inhibition of
acid ceramidase. ACS Chem Biol 14(1):11–19
33. Draper JM, Xia Z, Smith RA, Zhuang Y, Wang
W, Smith CD (2011) Discovery and evaluation
of inhibitors of human ceramidase. Mol Cancer
Ther 10(11):2052–2061
34. Vethakanraj HS, Babu TA, Sudarsanan GB,
Duraisamy PK, Kumar SA (2015) Targeting
ceramide metabolic pathway induces apoptosis in human breast cancer cell lines. Biochem
Biophys Res Commun 464(3):833–839
35. Kutlu, Hatice Mehtap, Gokhan KUS Use of
ceranib-2 in the treatment of lung cancer and
breast cancer. U.S. Patent Application 15/899,
520, filed August 23, 2018
36. Voelkel-Johnson C, Norris JS, WhiteGilbertson S (2018) Interdiction of sphingolipid metabolism revisited: Focus on prostate
cancer. Adv Cancer Res 140:265–293
37. Vethakanraj HS, Aslan M, Jayashree A, Priya
PV, Sekar AK (2018) Targeting ceramidase and
sphingosine kinase 1 of ceramide metabolic
pathway induces apoptosis in human colon
cancer cells. Int J Cell Sci Biotechnol 7:23–27.
https://doi.org/10.14741/ijcsb/v.7.3
38. Vejselova D (2016) Hatice Mehtap Kutlu,
and Gökhan Kuş. Examining impacts of ceranib- 2 on the proliferation, morphology and
ultrastructure of human breast cancer cells.
Cytotechnology 68(6):2721–2728
39. Nguyen H, Awad A, Shabani S, Doan N (2018)
Molecular targeting of acid ceramidase in glioblastoma: a review of its role, potential treatment, and challenges. Pharmaceutics 10(2):45
40. Mostafavi E, Soltantabar P, Webster TJ
(2019) Nanotechnology and picotechnology: a new arena for translational medicine. In: Biomaterials in translational
medicine. Academic Press, Cambridge, MA,
pp 191–212
41. Tabassum N, Verma V, Kumar M, Kumar A,
Singh B (2018) Nanomedicine in cancer stem
cell therapy: from fringe to forefront. Cell
Tissue Res 374(3):427–438
42. Tyagi
P,
Subramony
JA
(2018)
Nanotherapeutics in oral and parenteral drug
delivery: key learnings and future outlooks as
we think small. J Controlled Rel 272:159–168
43. Lim E-K, Chung BH, Chung SJ (2018) Recent
advances in pH-sensitive polymeric nanoparticles for smart drug delivery in cancer therapy.
Curr Drug Targets 19(4):300–317
44. Tamjidi F, Shahedi M, Varshosaz J, Nasirpour
A (2013) Nanostructured lipid carriers (NLC):
a potential delivery system for bioactive food
molecules. Innovative Food Sci Emerg Technol
19:29–43
45. Hughes GA (2017) Nanostructure-mediated
drug delivery. In: Nanomedicine in cancer. Pan
Stanford, Singapore, pp 47–72
46. Liu J, Huang Y, Kumar A, Tan A, Jin S, Mozhi
A, Liang X-J (2014) pH-sensitive nano-systems
for drug delivery in cancer therapy. Biotechnol
Adv 32(4):693–710
47. Nitta S, Numata K (2013) Biopolymer-based
nanoparticles for drug/gene delivery and tissue
engineering. Int J Mol Sci 14(1):1629–1654
48. Doppalapudi S, Jain A, Khan W, Domb AJ
(2014) Biodegradable polymers—an overview.
Polym Adv Technol 25(5):427–435
49. Liu D, Yang F, Xiong F, Ning G (2016) The
smart drug delivery system and its clinical
potential. Theranostics 6(9):1306
50. Mitragotri S, Burke PA, Langer R (2014)
Overcoming the challenges in administering
biopharmaceuticals: formulation and delivery
strategies. Nat Rev Drug Discov 13(9):655
51. Katouzian I, Jafari SM (2016) Nanoencapsulation as a promising approach for
targeted delivery and controlled release of vitamins. Trends Food Sci Technol 53:34–48
52. Frank LA, Contri RV, Beck CR, Pohlmann AR,
Guterres SS (2015) Improving drug biological
effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip Rev Nanomed
Nanobiotechnol 7(5):623–639
53. Masarudin MJ, Cutts SM, Evison BJ, Phillips
DR, Pigram PJ (2015) Factors determining the stability, size distribution, and cellular
accumulation of small, monodisperse chitosan
nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [14C]-doxorubicin.
Nanotechnol Sci Appl 8:67
54. dos Santos PP, Flôres SH, de Oliveira Rios A,
Chiste RC (2016) Biodegradable polymers as
wall materials to the synthesis of bioactive compound nanocapsules. Trends Food Sci Technol
53:23–33
55. Tang Z, He C, Tian H, Ding J, Hsiao BS, Chu
B, Chen X (2016) Polymeric nanostructured
materials for biomedical applications. Progr
Polym Sci 60:86–128
56. Kulkarni Vishakha SD, Kishor B, Sudha SR
(2012) Natural polymers—A comprehensive review. Int J Res Pharm Biomed Sci
3(4):1597–1613
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters