218
5. Kumaraswamy BV (1994) Ayurvedic identification and conceptual analysis of cancer. Anc
Sci Life 13(3–4):218–231
6. Hait WN (2010) Anticancer drug development: the grand challenges. Nat Rev Drug
Discov 9(4):253
7. Cragg GM, Newman DJ (2009) Nature: a vital
source of leads for anticancer drug development. Phytochem Rev 8(2):313–331
8. Spiegel S, Milstien S (2003) Sphingosine-1phosphate: an enigmatic signalling lipid. Nat
Rev Mol Cell Biol 4(5):397
9. Schneider G, Sellers ZP, Bujko K, Kakar SS,
Kucia M, Ratajczak MZ (2017) Novel pleiotropic effects of bioactive phospholipids in
human lung cancer metastasis. Oncotarget
8(35):58247
10. Ogretmen B (2018) Sphingolipid metabolism in cancer signalling and therapy. Nat Rev
Cancer 18(1):33
11. Kurz J, Parnham MJ, Geisslinger G, Schiffmann
S (2019) Ceramides as novel disease biomarkers. Trends Mol Med 25(1):20–32
12. Boojar MMA, Boojar MMA, Golmohammad
S, Yazdi MN (2018) Ceramide generation
as a novel biological mechanism for chemopreventive and cytotoxic effects of hesperidin
on HT-144 melanoma cells. Beni-Suef Univ J
Basic Appl Sci 7(4):640–645
13. Ogretmen B, Hannun YA (2004) Biologically
active sphingolipids in cancer pathogenesis and
treatment. Nat Rev Cancer 4(8):604
14. Morad SAF, Levin JC, Tan S-F, Fox TE,
Feith DJ, Cabot MC (2013) Novel offtarget effect of tamoxifen—inhibition of acid
ceramidase activity in cancer cells. Biochim
Biophys Acta (BBA)-Mol Cell Biol Lipids
1831(12):1657–1664
15. Kolesnick R, Fuks Z (2003) Radiation and
ceramide-induced
apoptosis.
Oncogene
22(37):5897
16. Hage-Sleiman R, Esmerian M, Kobeissy H,
Dbaibo G (2013) p53 and ceramide as collaborators in the stress response. Int J Mol Sci
14(3):4982–5012
17. Boojar MMA, Boojar MMA, Golmohammad
S, Bahrehbar I (2018) Data on cell survival,
apoptosis, ceramide metabolism and oxidative
stress in A-494 renal cell carcinoma cell line
treated with hesperetin and hesperetin-7-Oacetate. Data Brief 20:596–601
18. Chung C-Y, Chang Y-H, Chen G-J (2004)
Effects of lanthanum doping on the dielectric
properties of Ba (Fe 0.5 Nb 0.5) O 3 ceramic.
J Appl Phys 96(11):6624–6628
19. Lépine S, Allegood JC, Park M, Dent P,
Milstien S, Spiegel S (2011) Sphingosine-1phosphate phosphohydrolase-1 regulates ER
stress-induced autophagy. Cell Death Differ
18(2):350
20. Lavieu G, Scarlatti F, Sala G, Carpentier S,
Levade T, Ghidoni R, Botti J, Codogno P
(2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival
during nutrient starvation. J Biol Chem
281(13):8518–8527
21. Scarlatti F, Bauvy C, Ventruti A, Sala G,
Cluzeaud F, Vandewalle A, Ghidoni R,
Codogno P (2004) Ceramide-mediated macroautophagy involves inhibition of protein
kinase B and up-regulation of beclin 1. J Biol
Chem 279(18):18384–18391
22. Park KS, Kim M-K, Lee HY, Kim SD, Lee
SY, Kim JM, Ryu SH, Bae Y-S (2007) S1P
stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem
Biophys Res Commun 356(1):239–244
23. Zheng W, Kollmeyer J, Symolon H, Momin
A, Munter E, Wang E, Kelly S et al (2006)
Ceramides and other bioactive sphingolipid
backbones in health and disease: lipidomic
analysis, metabolism and roles in membrane
structure, dynamics, signaling and autophagy. Biochim Biophys Acta (BBA)-Biomembr
1758(12):1864–1884
24. Pyne NJ, Pyne S (2010) Sphingosine
1- phosphate and cancer. Nat Rev Cancer
10(7):489
25. Beckham TH, Cheng JC, Marrison ST, Norris
JS, Liu X (2013) Interdiction of sphingolipid
metabolism to improve standard cancer therapies.
Adv Cancer Res 117:1–36. Academic Press
26. Boojar MA, Mahdi MMAB, Golmohammad S
(2018) Ceramide pathway: A novel approach
to cancer chemotherapy. Egypt J Basic Appl Sci
5(4):237–244
27. Moro K, Kawaguchi T, Tsuchida J, Gabriel E,
Qi Q, Yan L, Wakai T, Takabe K, Nagahashi
M (2018) Ceramide species are elevated in
human breast cancer and are associated with
less aggressiveness. Oncotarget 9(28):19874
28. Vejselova D, Kutlu HM, Kuş G, Kabadere S,
Uyar R (2014) Cytotoxic and apoptotic effects
of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer
cells. Turkish J Biol 38(6):916–921
29. Liu H, Ma Y, He HW, Zhao WL, Shao RG
(2017) SPHK1 (sphingosine kinase 1) induces
epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
Autophagy 13(5):900–913
30. Bernardini S, Tiezzi A, Laghezza Masci V, Ovidi
E (2018) Natural products for human health:
Ali Ben Taleb et al.
5. Kumaraswamy BV (1994) Ayurvedic identification and conceptual analysis of cancer. Anc
Sci Life 13(3–4):218–231
6. Hait WN (2010) Anticancer drug development: the grand challenges. Nat Rev Drug
Discov 9(4):253
7. Cragg GM, Newman DJ (2009) Nature: a vital
source of leads for anticancer drug development. Phytochem Rev 8(2):313–331
8. Spiegel S, Milstien S (2003) Sphingosine-1phosphate: an enigmatic signalling lipid. Nat
Rev Mol Cell Biol 4(5):397
9. Schneider G, Sellers ZP, Bujko K, Kakar SS,
Kucia M, Ratajczak MZ (2017) Novel pleiotropic effects of bioactive phospholipids in
human lung cancer metastasis. Oncotarget
8(35):58247
10. Ogretmen B (2018) Sphingolipid metabolism in cancer signalling and therapy. Nat Rev
Cancer 18(1):33
11. Kurz J, Parnham MJ, Geisslinger G, Schiffmann
S (2019) Ceramides as novel disease biomarkers. Trends Mol Med 25(1):20–32
12. Boojar MMA, Boojar MMA, Golmohammad
S, Yazdi MN (2018) Ceramide generation
as a novel biological mechanism for chemopreventive and cytotoxic effects of hesperidin
on HT-144 melanoma cells. Beni-Suef Univ J
Basic Appl Sci 7(4):640–645
13. Ogretmen B, Hannun YA (2004) Biologically
active sphingolipids in cancer pathogenesis and
treatment. Nat Rev Cancer 4(8):604
14. Morad SAF, Levin JC, Tan S-F, Fox TE,
Feith DJ, Cabot MC (2013) Novel offtarget effect of tamoxifen—inhibition of acid
ceramidase activity in cancer cells. Biochim
Biophys Acta (BBA)-Mol Cell Biol Lipids
1831(12):1657–1664
15. Kolesnick R, Fuks Z (2003) Radiation and
ceramide-induced
apoptosis.
Oncogene
22(37):5897
16. Hage-Sleiman R, Esmerian M, Kobeissy H,
Dbaibo G (2013) p53 and ceramide as collaborators in the stress response. Int J Mol Sci
14(3):4982–5012
17. Boojar MMA, Boojar MMA, Golmohammad
S, Bahrehbar I (2018) Data on cell survival,
apoptosis, ceramide metabolism and oxidative
stress in A-494 renal cell carcinoma cell line
treated with hesperetin and hesperetin-7-Oacetate. Data Brief 20:596–601
18. Chung C-Y, Chang Y-H, Chen G-J (2004)
Effects of lanthanum doping on the dielectric
properties of Ba (Fe 0.5 Nb 0.5) O 3 ceramic.
J Appl Phys 96(11):6624–6628
19. Lépine S, Allegood JC, Park M, Dent P,
Milstien S, Spiegel S (2011) Sphingosine-1phosphate phosphohydrolase-1 regulates ER
stress-induced autophagy. Cell Death Differ
18(2):350
20. Lavieu G, Scarlatti F, Sala G, Carpentier S,
Levade T, Ghidoni R, Botti J, Codogno P
(2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival
during nutrient starvation. J Biol Chem
281(13):8518–8527
21. Scarlatti F, Bauvy C, Ventruti A, Sala G,
Cluzeaud F, Vandewalle A, Ghidoni R,
Codogno P (2004) Ceramide-mediated macroautophagy involves inhibition of protein
kinase B and up-regulation of beclin 1. J Biol
Chem 279(18):18384–18391
22. Park KS, Kim M-K, Lee HY, Kim SD, Lee
SY, Kim JM, Ryu SH, Bae Y-S (2007) S1P
stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem
Biophys Res Commun 356(1):239–244
23. Zheng W, Kollmeyer J, Symolon H, Momin
A, Munter E, Wang E, Kelly S et al (2006)
Ceramides and other bioactive sphingolipid
backbones in health and disease: lipidomic
analysis, metabolism and roles in membrane
structure, dynamics, signaling and autophagy. Biochim Biophys Acta (BBA)-Biomembr
1758(12):1864–1884
24. Pyne NJ, Pyne S (2010) Sphingosine
1- phosphate and cancer. Nat Rev Cancer
10(7):489
25. Beckham TH, Cheng JC, Marrison ST, Norris
JS, Liu X (2013) Interdiction of sphingolipid
metabolism to improve standard cancer therapies.
Adv Cancer Res 117:1–36. Academic Press
26. Boojar MA, Mahdi MMAB, Golmohammad S
(2018) Ceramide pathway: A novel approach
to cancer chemotherapy. Egypt J Basic Appl Sci
5(4):237–244
27. Moro K, Kawaguchi T, Tsuchida J, Gabriel E,
Qi Q, Yan L, Wakai T, Takabe K, Nagahashi
M (2018) Ceramide species are elevated in
human breast cancer and are associated with
less aggressiveness. Oncotarget 9(28):19874
28. Vejselova D, Kutlu HM, Kuş G, Kabadere S,
Uyar R (2014) Cytotoxic and apoptotic effects
of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer
cells. Turkish J Biol 38(6):916–921
29. Liu H, Ma Y, He HW, Zhao WL, Shao RG
(2017) SPHK1 (sphingosine kinase 1) induces
epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
Autophagy 13(5):900–913
30. Bernardini S, Tiezzi A, Laghezza Masci V, Ovidi
E (2018) Natural products for human health:
Ali Ben Taleb et al.