107
3. All companies that sell spectrometers generally have a library of
pulse programs and stored default parameter sets for common
1D and 2D NMR experiments.
4. There is no special precaution for the handling of free radicals,
which are spin labels and used for investigating structural
changes in lipids.
5. Although micelles are relatively stable, the noise of the spectrum is deteriorated if sample is not fresh.
6. It is essential the NMR spectrometer room temperature be stable during the experiment as the quality of the spectrum is
affected by temperature instability.
Acknowledgments
This work has been co-financed by the European Union and Greek
national funds through the program “Support for Researchers
with Emphasis on Young Researchers” (call code: EDBM34, ΚΕ
14995) and under the research title “Preparation and study of
innovative forms of administration of pharmaceutical molecules
targeting at improved pharmacological properties.” SGG acknowledges support from the Slovenian Research Agency (Grant No.
J1-8145).
References
1. Wang N, Cheng X, Li N, Hong W, Chen H
(2019) Nanocarriers and their loading strategies (review article). Adv Healthcare Mater
8(6). 1801002 (1–26)
2. Wang Y, He J, Liu C, Chong WH, Chen
H (2015) Thermodynamics versus kinetics in nanosynthesis. Angew Chem Int Ed
54(7):2022–2051
3. Mehta TJ, Motihal M, Patel MR et al (2011)
Optimization of granulation and compression
process variables of atenolol tablets using BoxBehnken design. Pharm Letter 3(3):103–109
4. Virna M, Gimenez M, Kassuha DE, Manucha
W (2017) Nanomedicine applied to cardiovascular diseases: latest developments. Ther Adv
Cardiovasc Dis 11(4):133–142
5. Diana D, Wangsa TI, Vincencius FM, Olivia MT,
Raymond RT, Heni R (2018) Bioconjugation
of captopril–light subunit of Agaricus bisporus
mushroom tyrosinase: characterization and
potential use as a drug carrier for oral delivery.
Biol Pharm Bull 41:1837–1842
6. Shahid N, Samiullah K, Umar F et al (2018)
Biocompatible hydrogels for the controlled
delivery of anti-hypertensive agent: development, characterization and in vitro evaluation.
Des Monomers Polym Ed 21:18–32
7. Sawani DT, Rahul VH, Rutesh HD (2019)
Evaluation of self-nanoemulsifying drug delivery systems using multivariate methods to optimize permeability of captopril oral films. Eur J
Pharm Sci 130:215–224
8. Sajjad AP, Hamid RS (2018) Captopril-loaded
superparamagnetic nanoparticles as a new dualmode contrast agent for simultaneous in vitro/
in vivo MR imaging and drug delivery system.
Pharm Chem J 10:852–862
9. Harshal AP, Lalitha KG, Ruckmani K (2015)
Beads of captopril using galactomannan containing Senna tora gum, guar gum and locust
bean gum. Int J Biol Macromol 76:119–131
10. Manhong L, Li Y, Xiaohui H, Xizhi L (2015)
Captopril-polyethyleneimine conjugate modified gold nanoparticles for co-delivery of
drug and gene in anti-angiogenesis breast
cancer therapy. J Biomater Sci Polym Ed
26(13):813–827
11. Oltenanu AA, Arama CC, Bleotu C, Lupuleasa
D, Monciu CM (2015) Investigation of cyclodextrin based nanosponges complexes with
Drug Incorporation in Micelles
3. All companies that sell spectrometers generally have a library of
pulse programs and stored default parameter sets for common
1D and 2D NMR experiments.
4. There is no special precaution for the handling of free radicals,
which are spin labels and used for investigating structural
changes in lipids.
5. Although micelles are relatively stable, the noise of the spectrum is deteriorated if sample is not fresh.
6. It is essential the NMR spectrometer room temperature be stable during the experiment as the quality of the spectrum is
affected by temperature instability.
Acknowledgments
This work has been co-financed by the European Union and Greek
national funds through the program “Support for Researchers
with Emphasis on Young Researchers” (call code: EDBM34, ΚΕ
14995) and under the research title “Preparation and study of
innovative forms of administration of pharmaceutical molecules
targeting at improved pharmacological properties.” SGG acknowledges support from the Slovenian Research Agency (Grant No.
J1-8145).
References
1. Wang N, Cheng X, Li N, Hong W, Chen H
(2019) Nanocarriers and their loading strategies (review article). Adv Healthcare Mater
8(6). 1801002 (1–26)
2. Wang Y, He J, Liu C, Chong WH, Chen
H (2015) Thermodynamics versus kinetics in nanosynthesis. Angew Chem Int Ed
54(7):2022–2051
3. Mehta TJ, Motihal M, Patel MR et al (2011)
Optimization of granulation and compression
process variables of atenolol tablets using BoxBehnken design. Pharm Letter 3(3):103–109
4. Virna M, Gimenez M, Kassuha DE, Manucha
W (2017) Nanomedicine applied to cardiovascular diseases: latest developments. Ther Adv
Cardiovasc Dis 11(4):133–142
5. Diana D, Wangsa TI, Vincencius FM, Olivia MT,
Raymond RT, Heni R (2018) Bioconjugation
of captopril–light subunit of Agaricus bisporus
mushroom tyrosinase: characterization and
potential use as a drug carrier for oral delivery.
Biol Pharm Bull 41:1837–1842
6. Shahid N, Samiullah K, Umar F et al (2018)
Biocompatible hydrogels for the controlled
delivery of anti-hypertensive agent: development, characterization and in vitro evaluation.
Des Monomers Polym Ed 21:18–32
7. Sawani DT, Rahul VH, Rutesh HD (2019)
Evaluation of self-nanoemulsifying drug delivery systems using multivariate methods to optimize permeability of captopril oral films. Eur J
Pharm Sci 130:215–224
8. Sajjad AP, Hamid RS (2018) Captopril-loaded
superparamagnetic nanoparticles as a new dualmode contrast agent for simultaneous in vitro/
in vivo MR imaging and drug delivery system.
Pharm Chem J 10:852–862
9. Harshal AP, Lalitha KG, Ruckmani K (2015)
Beads of captopril using galactomannan containing Senna tora gum, guar gum and locust
bean gum. Int J Biol Macromol 76:119–131
10. Manhong L, Li Y, Xiaohui H, Xizhi L (2015)
Captopril-polyethyleneimine conjugate modified gold nanoparticles for co-delivery of
drug and gene in anti-angiogenesis breast
cancer therapy. J Biomater Sci Polym Ed
26(13):813–827
11. Oltenanu AA, Arama CC, Bleotu C, Lupuleasa
D, Monciu CM (2015) Investigation of cyclodextrin based nanosponges complexes with
Drug Incorporation in Micelles