Table 1 Localization of cysteine residues according to the classification scheme by Chaikuad
et al. [7]
The positions or subsites (including several spatially similar locations) are assigned according to the
identifiers provided in Fig. 4. The list is based on the analysis of Chaikuad et al. [7] and has been
updated according to the literature available at the time of writing. The analysis did not include
atypical kinases while lipid kinases from the phosphoinositide 3-kinase family (PI3Ks) were
included. Assignments were made on the basis of respective X-ray crystal structures while cysteine
locations in kinases without an available X-ray crystal structure (shown in italics) were assigned by
sequence alignments. Kinases which have been targeted with covalent ligands are highlighted in
magenta and only examples where covalent binding was experimentally proven by either X-ray or
MS were included.
a Non-exhaustive, only positions/kinases that were already covalently addressed have been
considered
Covalent Kinase Inhibitors: An Overview
53
et al. [7]
The positions or subsites (including several spatially similar locations) are assigned according to the
identifiers provided in Fig. 4. The list is based on the analysis of Chaikuad et al. [7] and has been
updated according to the literature available at the time of writing. The analysis did not include
atypical kinases while lipid kinases from the phosphoinositide 3-kinase family (PI3Ks) were
included. Assignments were made on the basis of respective X-ray crystal structures while cysteine
locations in kinases without an available X-ray crystal structure (shown in italics) were assigned by
sequence alignments. Kinases which have been targeted with covalent ligands are highlighted in
magenta and only examples where covalent binding was experimentally proven by either X-ray or
MS were included.
a Non-exhaustive, only positions/kinases that were already covalently addressed have been
considered
Covalent Kinase Inhibitors: An Overview
53