58
V. K. Kannaujiya et al.
cyanobacterial genera. Cyanobacteria evolved as organisms capable of extreme adaptation, at several types of conditions. These adaptations are often related to the
production of defense machinery, producing many natural products and high-valued
compounds.
3.7 Commercial Significance of PBPs
In the past few years, PBPs are being used as emerging protein sources for the development of natural dyes, pharmaceuticals, autofluorescent chemical, neutraceuticals,
and many therapeutic and non-therapeutic bioproducts. Currently, a green approach
for generation of value-added therapeutic and daily use products have been widely
accepted by common people (Sekar and Chandramohan 2008). In current scenario,
PC and PE are frequently used as coloring agents for the development of colored
food products without using health-hazardous synthetic color (Prasanna et al. 2007).
Commercially, they are used in manufacturing edible food products, cold beverages, milk products, and autofluorescent sweet candies (Eriksen 2008, Kannaujiya
et al. 2017d). Now, certain companies of different countries focus on the development of PE/PC based natural cosmetic products such as soft cream, lotion, beauty
soaps, colored eyeliner, and lipsticks. Recently, PBPs application has been elaborated with novel potential in the field of cosmetics industry and biomedical research
for the treatment of many diseases (Richa et al. 2011, Kannaujiya et al. 2017c, d).
PBPs are also used as potent anti-oxidative agents due to reactive oxygen level scavenging property (Wu et al. 2016). It has been observed that PC and PCB exhibit
effective scavenging property of peroxynitrite which accelerate the DNA damage
(Bhat and Madyastha 2001). In addition, PC is further characterized by Oxygen
Radical Absorbance Capacity (ORAC) which indicates strong anti-oxidative potential (Benedetti et al. 2010). In addition, PBPs have also been used as food supplements
for enhancing immune system (Levi et al. 2018). Apart from antioxidant behavior,
PC shows immune-modulatory and anti-inflammatory agents (Datla 2011). Certain
biological experiment suggests that it has neuro-protective property (CervantesLlanos et al. 2018) and combination of PC- α-synuclein inhibit fibrils formation
in brains which cause reduction in development of neurodegenerative disease such
as Parkinson’s and Alzheimer (Liu et al. 2019, Kannaujiya et al. 2017c, d). They are
also hepatic-protective due to reduction in enzymes activity such as liver transaminases and alkaline phosphatase which is accelerated by oxidative stress (Gdara et al.
2018). PC is specifically toxic to cancer cells and inhibits the tumor growth (Jiang
et al. 2018, Ravi et al. 2015). Recently, PC has been used as a potent photosensitizer
as drug delivery for photodynamic therapy (Wan et al. 2017). It has been shown that
PC prevents the UV-induced apoptosis by regulation of proteins kiase (Kim et al.
2018). Moreover, Chakdar and Pabbi (2015) recognized that PC has a great ability
for reduction of animal cholesterol, low-density lipoproteins, and harmful level of
triglycerides.
V. K. Kannaujiya et al.
cyanobacterial genera. Cyanobacteria evolved as organisms capable of extreme adaptation, at several types of conditions. These adaptations are often related to the
production of defense machinery, producing many natural products and high-valued
compounds.
3.7 Commercial Significance of PBPs
In the past few years, PBPs are being used as emerging protein sources for the development of natural dyes, pharmaceuticals, autofluorescent chemical, neutraceuticals,
and many therapeutic and non-therapeutic bioproducts. Currently, a green approach
for generation of value-added therapeutic and daily use products have been widely
accepted by common people (Sekar and Chandramohan 2008). In current scenario,
PC and PE are frequently used as coloring agents for the development of colored
food products without using health-hazardous synthetic color (Prasanna et al. 2007).
Commercially, they are used in manufacturing edible food products, cold beverages, milk products, and autofluorescent sweet candies (Eriksen 2008, Kannaujiya
et al. 2017d). Now, certain companies of different countries focus on the development of PE/PC based natural cosmetic products such as soft cream, lotion, beauty
soaps, colored eyeliner, and lipsticks. Recently, PBPs application has been elaborated with novel potential in the field of cosmetics industry and biomedical research
for the treatment of many diseases (Richa et al. 2011, Kannaujiya et al. 2017c, d).
PBPs are also used as potent anti-oxidative agents due to reactive oxygen level scavenging property (Wu et al. 2016). It has been observed that PC and PCB exhibit
effective scavenging property of peroxynitrite which accelerate the DNA damage
(Bhat and Madyastha 2001). In addition, PC is further characterized by Oxygen
Radical Absorbance Capacity (ORAC) which indicates strong anti-oxidative potential (Benedetti et al. 2010). In addition, PBPs have also been used as food supplements
for enhancing immune system (Levi et al. 2018). Apart from antioxidant behavior,
PC shows immune-modulatory and anti-inflammatory agents (Datla 2011). Certain
biological experiment suggests that it has neuro-protective property (CervantesLlanos et al. 2018) and combination of PC- α-synuclein inhibit fibrils formation
in brains which cause reduction in development of neurodegenerative disease such
as Parkinson’s and Alzheimer (Liu et al. 2019, Kannaujiya et al. 2017c, d). They are
also hepatic-protective due to reduction in enzymes activity such as liver transaminases and alkaline phosphatase which is accelerated by oxidative stress (Gdara et al.
2018). PC is specifically toxic to cancer cells and inhibits the tumor growth (Jiang
et al. 2018, Ravi et al. 2015). Recently, PC has been used as a potent photosensitizer
as drug delivery for photodynamic therapy (Wan et al. 2017). It has been shown that
PC prevents the UV-induced apoptosis by regulation of proteins kiase (Kim et al.
2018). Moreover, Chakdar and Pabbi (2015) recognized that PC has a great ability
for reduction of animal cholesterol, low-density lipoproteins, and harmful level of
triglycerides.