190
M. R. Nikolic et al.
Table 8.1
(continued)
Disorder/disease model system PBP source
PBP activity
Experimental approach
References
Breast cancer MDA-MB-231
cell lines
PC
Anti-cancer
Cell viability, cycle, apoptosis,
migration, and colony formation
assays; assays for signaling
pathways involved in cell death
Jiang et al. (2018)
Breast cancer MDA-MB-231,
MCF-7, SKBR-3, BT-474, and
HBL-100 cell lines
PC
Anti-cancer and
anti-angiogenic
Cell viability, cycle, apoptosis,
migration, and colony formation
assays; angiogenic assay; assays
for signaling pathways involved
in cell death
Ravi et al. (2015)
Doxorubicin-induced oxidative
stress in rat cardiomyocytes
PC
Cardioprotective
Cell viability and apoptosis
assays; intracellular ROS
generation; assays for signaling
pathways involved in cell death
Khan et al. (2006)
B16F10 murine melanoma
cells
PC
Anti-melanogenic
Cell viability assay, tyrosinase
activity, and melanin content;
assays of signaling pathways
involved in melanogenesis
Wu et al. (2011)
AAPH-induced oxidative stress
in human erythrocytes
Natural PC and recombinant
apo-PC
Antioxidant
Hemolysis assay, electron
microscopy
Pleonsil et al. (2013)
Human colon T116 cancer cell
line
Encapsulated PC
Anti-cancer
Cell viability, cycle, and
apoptosis assays; assays for
signaling pathways involved in
cell death
Wen et al. (2019)