186
M. R. Nikolic et al.
Table 8.1
Selected examples of evaluation of biological activities of PBPs in vitro and in vivo. AAPH, 2,2’-Azobis(2-amidinopropane) dihydrochloride; GOT,
glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; ROS, reactive oxygen species; SOD, superoxide dismutase; TNF, Tumor necrosis
factor
Disorder/disease model system PBP source
PBP activity
Experimental approach
References
In vivo
Murine sarcoma 180-bearing
mice
PE
Anti-cancer
Tumor inhibitory rate and organ
index, SOD activity in liver and
serum, splenic lymphocyte
proliferation, natural killer cells
activity, and TNF secretion
capacity, histopathology of
tumors
Pan et al. (2013)
Caenorhabditis elegans/C.
elegans
CL4176 transgenic
model for Alzheimer’s disease
PE
Antioxidant and anti-aging Life span and stress resistance
assays, locomotion and
paralysis assays, expression of
signaling pathways involved in
aging; aggregation and
proteotoxicity-mediated
paralysis phenotype
Sonani et al. (2014a, b)
Acetic acid-induced colitis
(Sprague-Dawley rats)
PC extract
Anti-inflammatory
Myeloperoxidase activity,
histopathology, and electron
microscopy of colonic tissue
González et al. (1999)
Pancreatic adenocarcinoma
PANC-1 based tumor xenograft
(Mice)
PC
Anti-cancer
Tumor growth and weight, body
weight
Liao et al. (2016)
Kainic acid-induced
hippocampus neuronal damage
(Sprague-Dawley rats)
PC
Neuroprotective
Neurobehavioral activities, body
weight, expression of markers
of microglia and astroglia
Rimbau et al. (1999)
(continued)
M. R. Nikolic et al.
Table 8.1
Selected examples of evaluation of biological activities of PBPs in vitro and in vivo. AAPH, 2,2’-Azobis(2-amidinopropane) dihydrochloride; GOT,
glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; ROS, reactive oxygen species; SOD, superoxide dismutase; TNF, Tumor necrosis
factor
Disorder/disease model system PBP source
PBP activity
Experimental approach
References
In vivo
Murine sarcoma 180-bearing
mice
PE
Anti-cancer
Tumor inhibitory rate and organ
index, SOD activity in liver and
serum, splenic lymphocyte
proliferation, natural killer cells
activity, and TNF secretion
capacity, histopathology of
tumors
Pan et al. (2013)
Caenorhabditis elegans/C.
elegans
CL4176 transgenic
model for Alzheimer’s disease
PE
Antioxidant and anti-aging Life span and stress resistance
assays, locomotion and
paralysis assays, expression of
signaling pathways involved in
aging; aggregation and
proteotoxicity-mediated
paralysis phenotype
Sonani et al. (2014a, b)
Acetic acid-induced colitis
(Sprague-Dawley rats)
PC extract
Anti-inflammatory
Myeloperoxidase activity,
histopathology, and electron
microscopy of colonic tissue
González et al. (1999)
Pancreatic adenocarcinoma
PANC-1 based tumor xenograft
(Mice)
PC
Anti-cancer
Tumor growth and weight, body
weight
Liao et al. (2016)
Kainic acid-induced
hippocampus neuronal damage
(Sprague-Dawley rats)
PC
Neuroprotective
Neurobehavioral activities, body
weight, expression of markers
of microglia and astroglia
Rimbau et al. (1999)
(continued)