5 Carotenoid Overproduction in Microalgae: Biochemical …
119
Laje, K., Seger, M., Dungan, B., Cooke, P., Polle, J., & Holguin, F. O. (2019). Phytoene accumulation
in the novel microalga Chlorococcum sp. using the pigment synthesis inhibitor fluridone. Marine
Drugs, 17, 187.
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M., de Vos, R. C. H., et al.
(2010). Carotenoid and fatty acid metabolism in light-stressed Dunaliella salina. Biotechnology
and Bioengineering, 106, 638–648.
Langi, P., Kiokias, S., Varzakas, T., & Proestos, C. (2018). Carotenoids: From plants to food and
feed industries. In: C. Barreiro, & J.-L. Barredo (Eds.), Microbial carotenoids: Methods and
Protocols. New York, NY: Springer New York.
Le Goff, M., le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., et al.
(2019). Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in
human health and disease prevention. Biochimie, 167, 106–118.
Le Goff, M., Delbrut, A., Quinton, M., Pradelles, R., Bescher, M., Burel, A., et al. (2020). Protective
action of Ostreococcus tauri and Phaeodactylum tricornutum extracts towards benzo[a]pyreneinduced cytotoxicity in endothelial cells. Marine Drugs, 18, 3.
Lee, P. C., & Schmidt-Dannert, C. (2002). Metabolic engineering towards biotechological
production of carotenoids in microorganisms. Applied Microbiology and Biotechnology, 60, 1–11.
Lemoine, Y., & Schoefs, B. (2010). Secondary ketocarotenoid astaxanthin biosynthesis in algae: A
multifunctional response to stress. Photosynthesis Research, 106, 155–177.
Lemoine, Y., Rmiki, N.-E., Créach, A., Rachidi, J., & Schoefs, B. (2008). Cytoplasmic accumulation
of astaxanthin by the green alga Haematococcus pluvialis (Flotow). In: B. Schoefs (Ed.), Plant
Cell Compartiments. Kerala, India: Research Signpost.
Leon, R., Couso, I., & Ez, E. (2007). Metabolic engineering of ketocarotenoids biosynthesis in the
unicelullar microalga Chlamydomonas reinhardtii. Journal of Biotechnology, 130, 143–152.
Levitan, O., Dinamarca, J., Hochman, G., & Falkowski, P. G. (2014). Diatoms: A fossil fuel of the
future. Trends in Biotechnology, 32, 117–124.
Li, Z., Ma, X., Li, A., & Zhang, C. (2012a). A novel potential source of β-carotene: Eustigmatos cf.
polyphem (Eustigmatophyceae) and pilot β-carotene production in bubble column and flat panel
photobioreactors. Bioresource Technology, 117, 257–263.
Li, Z., Sun, M., Li, Q., Li, A., & Zhang, C. (2012b). Profiling of carotenoids in six microalgae (Eustigmatophyceae) and assessment of their β-carotene productions in bubble column photobioreactor.
Biotechnology Letters, 34, 2049–2053.
Li, J., Niu, X., Pei, G., Sui, X., Zhang, X., Chen, L., et al. (2015). Identification and metabolomic
analysis of chemical modulators for lipid accumulation in Crypthecodinium cohnii. Bioresource
Technology, 191, 362–368.
Li, K., Cheng, J., Lu, H., Yang, W., Zhou, J., & Cen, K. (2017). Transcriptome-based analysis on
carbon metabolism of Haematococcus pluvialis mutant under 15% CO2. Bioresource Technology,
233, 313–321.
Lichtenthaler, H. K. (1999). The 1-deoxy-D-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annual Review in Plant Physiology and Plant Molecular Biology, 50,
47–65.
Lichthenthaler, H. K. (1998). The plants’ 1-deoxy-D-xylulose-5-phosphate pathway for biosynthesis of isoprenoids. Lipid, 100, 128–138.
Lin, J.-H., Lee, D.-J., & Chang, J.-S. (2015). Lutein production from biomass: Marigold flowers
versus microalgae. Bioresource Technology, 184, 421–428.
Liu, J., Gerken, H., Huang, J., & Chen, F. (2013a). Engineering of an endogenous phytoene desaturase gene as a dominant selectable marker for Chlamydomonas reinhardtii transformation and
enhanced biosynthesis of carotenoids. Process Biochemistry, 48, 788–795.
Liu, Z., Liu, C., Hou, Y., Shulin, C., Xiao, D., Zhang, J., et al. (2013b). Isolation and characterization
of a marine microalga for biofuel production with astaxanthin as a co-product. Energies, 6,
2759–2772.
119
Laje, K., Seger, M., Dungan, B., Cooke, P., Polle, J., & Holguin, F. O. (2019). Phytoene accumulation
in the novel microalga Chlorococcum sp. using the pigment synthesis inhibitor fluridone. Marine
Drugs, 17, 187.
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M., de Vos, R. C. H., et al.
(2010). Carotenoid and fatty acid metabolism in light-stressed Dunaliella salina. Biotechnology
and Bioengineering, 106, 638–648.
Langi, P., Kiokias, S., Varzakas, T., & Proestos, C. (2018). Carotenoids: From plants to food and
feed industries. In: C. Barreiro, & J.-L. Barredo (Eds.), Microbial carotenoids: Methods and
Protocols. New York, NY: Springer New York.
Le Goff, M., le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., et al.
(2019). Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in
human health and disease prevention. Biochimie, 167, 106–118.
Le Goff, M., Delbrut, A., Quinton, M., Pradelles, R., Bescher, M., Burel, A., et al. (2020). Protective
action of Ostreococcus tauri and Phaeodactylum tricornutum extracts towards benzo[a]pyreneinduced cytotoxicity in endothelial cells. Marine Drugs, 18, 3.
Lee, P. C., & Schmidt-Dannert, C. (2002). Metabolic engineering towards biotechological
production of carotenoids in microorganisms. Applied Microbiology and Biotechnology, 60, 1–11.
Lemoine, Y., & Schoefs, B. (2010). Secondary ketocarotenoid astaxanthin biosynthesis in algae: A
multifunctional response to stress. Photosynthesis Research, 106, 155–177.
Lemoine, Y., Rmiki, N.-E., Créach, A., Rachidi, J., & Schoefs, B. (2008). Cytoplasmic accumulation
of astaxanthin by the green alga Haematococcus pluvialis (Flotow). In: B. Schoefs (Ed.), Plant
Cell Compartiments. Kerala, India: Research Signpost.
Leon, R., Couso, I., & Ez, E. (2007). Metabolic engineering of ketocarotenoids biosynthesis in the
unicelullar microalga Chlamydomonas reinhardtii. Journal of Biotechnology, 130, 143–152.
Levitan, O., Dinamarca, J., Hochman, G., & Falkowski, P. G. (2014). Diatoms: A fossil fuel of the
future. Trends in Biotechnology, 32, 117–124.
Li, Z., Ma, X., Li, A., & Zhang, C. (2012a). A novel potential source of β-carotene: Eustigmatos cf.
polyphem (Eustigmatophyceae) and pilot β-carotene production in bubble column and flat panel
photobioreactors. Bioresource Technology, 117, 257–263.
Li, Z., Sun, M., Li, Q., Li, A., & Zhang, C. (2012b). Profiling of carotenoids in six microalgae (Eustigmatophyceae) and assessment of their β-carotene productions in bubble column photobioreactor.
Biotechnology Letters, 34, 2049–2053.
Li, J., Niu, X., Pei, G., Sui, X., Zhang, X., Chen, L., et al. (2015). Identification and metabolomic
analysis of chemical modulators for lipid accumulation in Crypthecodinium cohnii. Bioresource
Technology, 191, 362–368.
Li, K., Cheng, J., Lu, H., Yang, W., Zhou, J., & Cen, K. (2017). Transcriptome-based analysis on
carbon metabolism of Haematococcus pluvialis mutant under 15% CO2. Bioresource Technology,
233, 313–321.
Lichtenthaler, H. K. (1999). The 1-deoxy-D-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annual Review in Plant Physiology and Plant Molecular Biology, 50,
47–65.
Lichthenthaler, H. K. (1998). The plants’ 1-deoxy-D-xylulose-5-phosphate pathway for biosynthesis of isoprenoids. Lipid, 100, 128–138.
Lin, J.-H., Lee, D.-J., & Chang, J.-S. (2015). Lutein production from biomass: Marigold flowers
versus microalgae. Bioresource Technology, 184, 421–428.
Liu, J., Gerken, H., Huang, J., & Chen, F. (2013a). Engineering of an endogenous phytoene desaturase gene as a dominant selectable marker for Chlamydomonas reinhardtii transformation and
enhanced biosynthesis of carotenoids. Process Biochemistry, 48, 788–795.
Liu, Z., Liu, C., Hou, Y., Shulin, C., Xiao, D., Zhang, J., et al. (2013b). Isolation and characterization
of a marine microalga for biofuel production with astaxanthin as a co-product. Energies, 6,
2759–2772.