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Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R (2015) Epithelial-to-mesenchymal transition is dispensable for metastasis but induces
chemoresistance in pancreatic cancer. Nature
527(7579):525–530.
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1038/nature16064
21. Stemmler MP, Eccles RL, Brabletz S, Brabletz
T (2019) Non-redundant functions of EMT
transcription factors. Nat Cell Biol 21
(1):102–112.
https://doi.org/10.1038/
s41556-018-0196-y
22. Pastushenko I, Brisebarre A, Sifrim A,
Fioramonti M, Revenco T, Boumahdi S, Van
Keymeulen A, Brown D, Moers V, Lemaire S,
De Clercq S, Minguijon E, Balsat C,
Sokolow Y, Dubois C, De Cock F,
Scozzaro S, Sopena F, Lanas A, D’Haene N,
Salmon I, Marine JC, Voet T, Sotiropoulou PA,
Blanpain C (2018) Identification of the
tumour transition states occurring during
EMT. Nature 556(7702):463–468. https://
doi.org/10.1038/s41586-018-0040-3
23. Chaffer CL, Weinberg RA (2015) How does
multistep tumorigenesis really proceed? Cancer
Discov
5(1):22–24.
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1158/2159-8290.CD-14-0788
24. Li Q, Hutchins AP, Chen Y, Li S, Shan Y,
Liao B, Zheng D, Shi X, Li Y, Chan WY,
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hepatocytes. Nat Commun 8:15166. https://
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25. Pei D, Shu X, Gassama-Diagne A, Thiery JP
(2019) Mesenchymal-epithelial transition in
development and reprogramming. Nat Cell
Biol 21(1):44–53. https://doi.org/10.1038/
s41556-018-0195-z
26. Ishay-Ronen D, Diepenbruck M, Kalathur
RKR, Sugiyama N, Tiede S, Ivanek R,
Bantug G, Morini MF, Wang J, Hess C, Christofori G (2019) Gain fat-lose metastasis: converting invasive breast cancer cells into
adipocytes inhibits cancer metastasis. Cancer
Cell 35(1):17–32. e16. https://doi.org/10.
1016/j.ccell.2018.12.002
27. Sarrio D, Rodriguez-Pinilla SM, Hardisson D,
Cano A, Moreno-Bueno G, Palacios J (2008)
Epithelial-mesenchymal transition in breast
cancer relates to the basal-like phenotype. Cancer Res 68(4):989–997. https://doi.org/10.
1158/0008-5472.CAN-07-2017
28. Yadavalli S, Jayaram S, Manda SS, Madugundu
AK, Nayakanti DS, Tan TZ, Bhat R,
Rangarajan A, Chatterjee A, Gowda H, Thiery
JP, Kumar P (2017) Data-driven discovery of
extravasation pathway in circulating tumor
cells. Sci Rep 7:43710. https://doi.org/10.
1038/srep43710
29. Yu M, Bardia A, Wittner BS, Stott SL, Smas
ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells
MN, Shah AM, Concannon KF, Donaldson
MC, Sequist LV, Brachtel E, Sgroi D,
Baselga J, Ramaswamy S, Toner M, Haber
DA, Maheswaran S (2013) Circulating breast
tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science
339(6119):580–584.
https://doi.org/10.
1126/science.1228522
EMT: An Update
39
Nieto MA, Stanger BZ, Yang J, Weinberg RA
(2017) Upholding a role for EMT in breast
cancer metastasis. Nature 547(7661):E1–E3.
https://doi.org/10.1038/nature22816
20. Zheng X, Carstens JL, Kim J, Scheible M,
Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R (2015) Epithelial-to-mesenchymal transition is dispensable for metastasis but induces
chemoresistance in pancreatic cancer. Nature
527(7579):525–530.
https://doi.org/10.
1038/nature16064
21. Stemmler MP, Eccles RL, Brabletz S, Brabletz
T (2019) Non-redundant functions of EMT
transcription factors. Nat Cell Biol 21
(1):102–112.
https://doi.org/10.1038/
s41556-018-0196-y
22. Pastushenko I, Brisebarre A, Sifrim A,
Fioramonti M, Revenco T, Boumahdi S, Van
Keymeulen A, Brown D, Moers V, Lemaire S,
De Clercq S, Minguijon E, Balsat C,
Sokolow Y, Dubois C, De Cock F,
Scozzaro S, Sopena F, Lanas A, D’Haene N,
Salmon I, Marine JC, Voet T, Sotiropoulou PA,
Blanpain C (2018) Identification of the
tumour transition states occurring during
EMT. Nature 556(7702):463–468. https://
doi.org/10.1038/s41586-018-0040-3
23. Chaffer CL, Weinberg RA (2015) How does
multistep tumorigenesis really proceed? Cancer
Discov
5(1):22–24.
https://doi.org/10.
1158/2159-8290.CD-14-0788
24. Li Q, Hutchins AP, Chen Y, Li S, Shan Y,
Liao B, Zheng D, Shi X, Li Y, Chan WY,
Pan G, Wei S, Shu X, Pei D (2017) A sequential
EMT-MET mechanism drives the differentiation of human embryonic stem cells towards
hepatocytes. Nat Commun 8:15166. https://
doi.org/10.1038/ncomms15166
25. Pei D, Shu X, Gassama-Diagne A, Thiery JP
(2019) Mesenchymal-epithelial transition in
development and reprogramming. Nat Cell
Biol 21(1):44–53. https://doi.org/10.1038/
s41556-018-0195-z
26. Ishay-Ronen D, Diepenbruck M, Kalathur
RKR, Sugiyama N, Tiede S, Ivanek R,
Bantug G, Morini MF, Wang J, Hess C, Christofori G (2019) Gain fat-lose metastasis: converting invasive breast cancer cells into
adipocytes inhibits cancer metastasis. Cancer
Cell 35(1):17–32. e16. https://doi.org/10.
1016/j.ccell.2018.12.002
27. Sarrio D, Rodriguez-Pinilla SM, Hardisson D,
Cano A, Moreno-Bueno G, Palacios J (2008)
Epithelial-mesenchymal transition in breast
cancer relates to the basal-like phenotype. Cancer Res 68(4):989–997. https://doi.org/10.
1158/0008-5472.CAN-07-2017
28. Yadavalli S, Jayaram S, Manda SS, Madugundu
AK, Nayakanti DS, Tan TZ, Bhat R,
Rangarajan A, Chatterjee A, Gowda H, Thiery
JP, Kumar P (2017) Data-driven discovery of
extravasation pathway in circulating tumor
cells. Sci Rep 7:43710. https://doi.org/10.
1038/srep43710
29. Yu M, Bardia A, Wittner BS, Stott SL, Smas
ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells
MN, Shah AM, Concannon KF, Donaldson
MC, Sequist LV, Brachtel E, Sgroi D,
Baselga J, Ramaswamy S, Toner M, Haber
DA, Maheswaran S (2013) Circulating breast
tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science
339(6119):580–584.
https://doi.org/10.
1126/science.1228522
EMT: An Update
39