References
1. Lim J, Thiery JP (2012) Epithelialmesenchymal transitions: insights from development. Development 139(19):3471–3486.
https://doi.org/10.1242/dev.071209
2. Erkenbrack EM, Davidson EH, Peter IS
(2018) Conserved regulatory state expression
controlled by divergent developmental gene
regulatory networks in echinoids. Development 145(24). https://doi.org/10.1242/dev.
167288
3. Martik ML, Bronner ME (2017) Regulatory
logic underlying diversification of the neural
crest.
Trends
Genet
33(10):715–727.
https://doi.org/10.1016/j.tig.2017.07.015
4. Saunders LR, McClay DR (2014) Sub-circuits
of a gene regulatory network control a developmental epithelial-mesenchymal transition.
Development 141(7):1503–1513. https://
doi.org/10.1242/dev.101436
5. Dongre A, Weinberg RA (2019) New insights
into the mechanisms of epithelial-mesenchymal
transition and implications for cancer. Nat Rev
Mol Cell Biol 20(2):69–84. https://doi.org/
10.1038/s41580-018-0080-4
6. Tam WL, Weinberg RA (2013) The epigenetics of epithelial-mesenchymal plasticity in
cancer. Nat Med 19(11):1438–1449. https://
doi.org/10.1038/nm.3336
7. Climente-Gonzalez H, Porta-Pardo E,
Godzik A, Eyras E (2017) The functional
impact of alternative splicing in cancer. Cell
Rep 20(9):2215–2226. https://doi.org/10.
1016/j.celrep.2017.08.012
8. De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation
and progression. Nat Rev Cancer 13
(2):97–110.
https://doi.org/10.1038/
nrc3447
9. Shaul YD, Freinkman E, Comb WC, Cantor
JR, Tam WL, Thiru P, Kim D, Kanarek N,
Pacold ME, Chen WW, Bierie B,
Possemato R, Reinhardt F, Weinberg RA,
Yaffe MB, Sabatini DM (2014) Dihydropyrimidine accumulation is required for the
epithelial-mesenchymal transition. Cell 158
(5):1094–1109. https://doi.org/10.1016/j.
cell.2014.07.032
10. Krishnan V, Chong YL, Tan TZ, Kulkarni M,
Bin Rahmat MB, Tay LS, Sankar H, Jokhun
DS, Ganesan A, Chuang LSH, Voon DC, Shivashankar GV, Thiery JP, Ito Y (2018)
TGFbeta promotes genomic instability after
loss of RUNX3. Cancer Res 78(1):88–102.
https://doi.org/10.1158/0008-5472.CAN17-1178
11. Prakash V, Carson BB, Feenstra JM, Dass RA,
Sekyrova P, Hoshino A, Petersen J, Guo Y,
Parks MM, Kurylo CM, Batchelder JE,
Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA,
Andang M, Percipalle P, Bergh J,
Adameyko I, Farrants AO, Hartman J,
Lyden D, Pietras K, Blanchard SC, Vincent
CT (2019) Ribosome biogenesis during cell
cycle arrest fuels EMT in development and
disease. Nat Commun 10(1):2110. https://
doi.org/10.1038/s41467-019-10100-8
12. Celia-Terrassa T, Bastian C, Liu DD, Ell B,
Aiello NM, Wei Y, Zamalloa J, Blanco AM,
Hang X, Kunisky D, Li W, Williams ED,
Rabitz H, Kang Y (2018) Hysteresis control
of epithelial-mesenchymal transition dynamics
conveys a distinct program with enhanced metastatic ability. Nat Commun 9(1):5005.
https://doi.org/10.1038/s41467-01807538-7
13. George JT, Jolly MK, Xu S, Somarelli JA,
Levine H (2017) Survival outcomes in cancer
patients predicted by a partial EMT gene
expression scoring metric. Cancer Res 77
(22):6415–6428. https://doi.org/10.1158/
0008-5472.CAN-16-3521
14. Tan TZ, Miow QH, Miki Y, Noda T, Mori S,
Huang RY, Thiery JP (2014) Epithelialmesenchymal transition spectrum quantification and its efficacy in deciphering survival
and drug responses of cancer patients. EMBO
Mol Med 6(10):1279–1293. https://doi.org/
10.15252/emmm.201404208
15. Aiello NM, Brabletz T, Kang Y, Nieto MA,
Weinberg RA, Stanger BZ (2017) Upholding
a role for EMT in pancreatic cancer metastasis.
Nature 547(7661):E7–E8. https://doi.org/
10.1038/nature22963
16. Brabletz T, Kalluri R, Nieto MA, Weinberg RA
(2018) EMT in cancer. Nat Rev Cancer 18
(2):128–134. https://doi.org/10.1038/nrc.
2017.118
17. Fischer KR, Altorki NK, Mittal V, Gao D
(2017) Fischer et al. reply. Nature 547(7661):
E5–E6.
https://doi.org/10.1038/
nature22817
18. Fischer KR, Durrans A, Lee S, Sheng J, Li F,
Wong ST, Choi H, El Rayes T, Ryu S,
Troeger J, Schwabe RF, Vahdat LT, Altorki
NK, Mittal V, Gao D (2015) Epithelial-to-mesenchymal transition is not required for lung
metastasis but contributes to chemoresistance.
Nature 527(7579):472–476. https://doi.org/
10.1038/nature15748
38
Jean Paul Thiery
1. Lim J, Thiery JP (2012) Epithelialmesenchymal transitions: insights from development. Development 139(19):3471–3486.
https://doi.org/10.1242/dev.071209
2. Erkenbrack EM, Davidson EH, Peter IS
(2018) Conserved regulatory state expression
controlled by divergent developmental gene
regulatory networks in echinoids. Development 145(24). https://doi.org/10.1242/dev.
167288
3. Martik ML, Bronner ME (2017) Regulatory
logic underlying diversification of the neural
crest.
Trends
Genet
33(10):715–727.
https://doi.org/10.1016/j.tig.2017.07.015
4. Saunders LR, McClay DR (2014) Sub-circuits
of a gene regulatory network control a developmental epithelial-mesenchymal transition.
Development 141(7):1503–1513. https://
doi.org/10.1242/dev.101436
5. Dongre A, Weinberg RA (2019) New insights
into the mechanisms of epithelial-mesenchymal
transition and implications for cancer. Nat Rev
Mol Cell Biol 20(2):69–84. https://doi.org/
10.1038/s41580-018-0080-4
6. Tam WL, Weinberg RA (2013) The epigenetics of epithelial-mesenchymal plasticity in
cancer. Nat Med 19(11):1438–1449. https://
doi.org/10.1038/nm.3336
7. Climente-Gonzalez H, Porta-Pardo E,
Godzik A, Eyras E (2017) The functional
impact of alternative splicing in cancer. Cell
Rep 20(9):2215–2226. https://doi.org/10.
1016/j.celrep.2017.08.012
8. De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation
and progression. Nat Rev Cancer 13
(2):97–110.
https://doi.org/10.1038/
nrc3447
9. Shaul YD, Freinkman E, Comb WC, Cantor
JR, Tam WL, Thiru P, Kim D, Kanarek N,
Pacold ME, Chen WW, Bierie B,
Possemato R, Reinhardt F, Weinberg RA,
Yaffe MB, Sabatini DM (2014) Dihydropyrimidine accumulation is required for the
epithelial-mesenchymal transition. Cell 158
(5):1094–1109. https://doi.org/10.1016/j.
cell.2014.07.032
10. Krishnan V, Chong YL, Tan TZ, Kulkarni M,
Bin Rahmat MB, Tay LS, Sankar H, Jokhun
DS, Ganesan A, Chuang LSH, Voon DC, Shivashankar GV, Thiery JP, Ito Y (2018)
TGFbeta promotes genomic instability after
loss of RUNX3. Cancer Res 78(1):88–102.
https://doi.org/10.1158/0008-5472.CAN17-1178
11. Prakash V, Carson BB, Feenstra JM, Dass RA,
Sekyrova P, Hoshino A, Petersen J, Guo Y,
Parks MM, Kurylo CM, Batchelder JE,
Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA,
Andang M, Percipalle P, Bergh J,
Adameyko I, Farrants AO, Hartman J,
Lyden D, Pietras K, Blanchard SC, Vincent
CT (2019) Ribosome biogenesis during cell
cycle arrest fuels EMT in development and
disease. Nat Commun 10(1):2110. https://
doi.org/10.1038/s41467-019-10100-8
12. Celia-Terrassa T, Bastian C, Liu DD, Ell B,
Aiello NM, Wei Y, Zamalloa J, Blanco AM,
Hang X, Kunisky D, Li W, Williams ED,
Rabitz H, Kang Y (2018) Hysteresis control
of epithelial-mesenchymal transition dynamics
conveys a distinct program with enhanced metastatic ability. Nat Commun 9(1):5005.
https://doi.org/10.1038/s41467-01807538-7
13. George JT, Jolly MK, Xu S, Somarelli JA,
Levine H (2017) Survival outcomes in cancer
patients predicted by a partial EMT gene
expression scoring metric. Cancer Res 77
(22):6415–6428. https://doi.org/10.1158/
0008-5472.CAN-16-3521
14. Tan TZ, Miow QH, Miki Y, Noda T, Mori S,
Huang RY, Thiery JP (2014) Epithelialmesenchymal transition spectrum quantification and its efficacy in deciphering survival
and drug responses of cancer patients. EMBO
Mol Med 6(10):1279–1293. https://doi.org/
10.15252/emmm.201404208
15. Aiello NM, Brabletz T, Kang Y, Nieto MA,
Weinberg RA, Stanger BZ (2017) Upholding
a role for EMT in pancreatic cancer metastasis.
Nature 547(7661):E7–E8. https://doi.org/
10.1038/nature22963
16. Brabletz T, Kalluri R, Nieto MA, Weinberg RA
(2018) EMT in cancer. Nat Rev Cancer 18
(2):128–134. https://doi.org/10.1038/nrc.
2017.118
17. Fischer KR, Altorki NK, Mittal V, Gao D
(2017) Fischer et al. reply. Nature 547(7661):
E5–E6.
https://doi.org/10.1038/
nature22817
18. Fischer KR, Durrans A, Lee S, Sheng J, Li F,
Wong ST, Choi H, El Rayes T, Ryu S,
Troeger J, Schwabe RF, Vahdat LT, Altorki
NK, Mittal V, Gao D (2015) Epithelial-to-mesenchymal transition is not required for lung
metastasis but contributes to chemoresistance.
Nature 527(7579):472–476. https://doi.org/
10.1038/nature15748
38
Jean Paul Thiery