5 Retinoic Acid Signaling and Heart Development
141
D’Aniello E, Waxman JS (2015) Input overload: Contributions of retinoic acid signaling feedback
mechanisms to heart development and teratogenesis. Dev Dyn 244:513–523. https://doi.org/10.
1002/dvdy.24232
De Bono C, Thellier C, Bertrand N, Sturny R, Jullian E, Cortes C, Stefanovic S, Zaffran S, ThéveniauRuissy M, Kelly RG (2018) T-box genes and retinoic acid signaling regulate the segregation
of arterial and venous pole progenitor cells in the murine second heart field. Hum Mol Genet
27:3747–3760. https://doi.org/10.1093/hmg/ddy266
Delacroix L, Moutier E, Altobelli G, Legras S, Poch O, Choukrallah M-A, Bertin I, Jost B, Davidson I (2010) Cell-Specific Interaction of Retinoic Acid Receptors with Target Genes in Mouse
Embryonic Fibroblasts and Embryonic Stem Cells. Mol Cell Biol 30:231–244. https://doi.org/
10.1128/MCB.00756-09
Dersch H, Zile MH (1993) Induction of Normal Cardiovascular Development in the Vitamin ADeprived Quail Embryo by Natural Retinoids. Dev Biol 160:424–433. https://doi.org/10.1006/
dbio.1993.1318
Devalla HD, Schwach V, Ford JW, Milnes JT, El-Haou S, Jackson C, Gkatzis K, Elliott DA, Chuva
de Sousa Lopes SM, Mummery CL, Verkerk AO, Passier R (2015) Atrial-like cardiomyocytes
from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective
pharmacology. EMBO Mol Med. 7:394–410. https://doi.org/10.15252/emmm.201404757
Dickman ED, Thaller C, Smith SM (1997) Temporally-regulated retinoic acid depletion produces
specific neural crest, ocular and nervous system defects. Development. 124:3111–3121
Dirks RAM, Stunnenberg HG, Marks H (2016) Genome-wide epigenomic profiling for biomarker
discovery. Clin Epigenetics. 8:122. https://doi.org/10.1186/s13148-016-0284-4
Dobbs-McAuliffe B, Zhao Q, Linney E (2004) Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mech Dev 121:339–350. https://doi.org/10.1016/
j.mod.2004.02.008
Dohn TE, Ravisankar P, Tirera FT, Martin KE, Gafranek JT, Duong TB, VanDyke TL, Touvron M,
Barske LA, Crump JG, Waxman JS (2019) Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genet 15:e1007962. https://doi.org/10.1371/
journal.pgen.1007962
Duester G (2008) Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell 134:921–
931. https://doi.org/10.1016/j.cell.2008.09.002
Dupé V, Davenne M, Brocard J, Dollé P, Mark M, Dierich A, Chambon P, Rijli FM (1997) In vivo
functional analysis of the Hoxa-1 3’ retinoic acid response element (3’RARE). Development.
124:399–410. https://doi.org/10.1080/09593330.2013.765921
Dupé V, Ghyselinck NB, Wendling O, Chambon P, Mark M (1999) Key roles of retinoic acid
receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst
in the mouse. Development. 126:5051–9. https://doi.org/10.1074/jbc.M511523200
Durston AJ, Timmermans JPM, Hage WJ, Hendriks HFJ, de Vries NJ, Heideveld M, Nieuwkoop PD
(1989) Retinoic acid causes an anteroposterior transformation in the developing central nervous
system. Nature 340:140–144. https://doi.org/10.1038/340140a0
Edwards MK, McBurney MW (1983) The concentration of retinoic acid determines the differentiated cell types formed by a teratocarcinoma cell line. Dev Biol 98:187–91
El Robrini N, Etchevers HC, Ryckebüsch L, Faure E, Eudes N, Niederreither K, Zaffran S, Bertrand
N (2016) Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple
cell lineages. Dev Dyn 245:388–401. https://doi.org/10.1002/dvdy.24357
Emoto Y, Wada H, Okamoto H, Kudo A, Imai Y (2005) Retinoic acid-metabolizing enzyme Cyp26a1
is essential for determining territories of hindbrain and spinal cord in zebrafish. Dev Biol 278:415–
427. https://doi.org/10.1016/J.YDBIO.2004.11.023
Feng L, Hernandez RE, Waxman JS, Yelon D, Moens CB (2010) Dhrs3a regulates retinoic acid
biosynthesis through a feedback inhibition mechanism. Dev Biol 338:1–14. https://doi.org/10.
1016/j.ydbio.2009.10.029
141
D’Aniello E, Waxman JS (2015) Input overload: Contributions of retinoic acid signaling feedback
mechanisms to heart development and teratogenesis. Dev Dyn 244:513–523. https://doi.org/10.
1002/dvdy.24232
De Bono C, Thellier C, Bertrand N, Sturny R, Jullian E, Cortes C, Stefanovic S, Zaffran S, ThéveniauRuissy M, Kelly RG (2018) T-box genes and retinoic acid signaling regulate the segregation
of arterial and venous pole progenitor cells in the murine second heart field. Hum Mol Genet
27:3747–3760. https://doi.org/10.1093/hmg/ddy266
Delacroix L, Moutier E, Altobelli G, Legras S, Poch O, Choukrallah M-A, Bertin I, Jost B, Davidson I (2010) Cell-Specific Interaction of Retinoic Acid Receptors with Target Genes in Mouse
Embryonic Fibroblasts and Embryonic Stem Cells. Mol Cell Biol 30:231–244. https://doi.org/
10.1128/MCB.00756-09
Dersch H, Zile MH (1993) Induction of Normal Cardiovascular Development in the Vitamin ADeprived Quail Embryo by Natural Retinoids. Dev Biol 160:424–433. https://doi.org/10.1006/
dbio.1993.1318
Devalla HD, Schwach V, Ford JW, Milnes JT, El-Haou S, Jackson C, Gkatzis K, Elliott DA, Chuva
de Sousa Lopes SM, Mummery CL, Verkerk AO, Passier R (2015) Atrial-like cardiomyocytes
from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective
pharmacology. EMBO Mol Med. 7:394–410. https://doi.org/10.15252/emmm.201404757
Dickman ED, Thaller C, Smith SM (1997) Temporally-regulated retinoic acid depletion produces
specific neural crest, ocular and nervous system defects. Development. 124:3111–3121
Dirks RAM, Stunnenberg HG, Marks H (2016) Genome-wide epigenomic profiling for biomarker
discovery. Clin Epigenetics. 8:122. https://doi.org/10.1186/s13148-016-0284-4
Dobbs-McAuliffe B, Zhao Q, Linney E (2004) Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mech Dev 121:339–350. https://doi.org/10.1016/
j.mod.2004.02.008
Dohn TE, Ravisankar P, Tirera FT, Martin KE, Gafranek JT, Duong TB, VanDyke TL, Touvron M,
Barske LA, Crump JG, Waxman JS (2019) Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genet 15:e1007962. https://doi.org/10.1371/
journal.pgen.1007962
Duester G (2008) Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell 134:921–
931. https://doi.org/10.1016/j.cell.2008.09.002
Dupé V, Davenne M, Brocard J, Dollé P, Mark M, Dierich A, Chambon P, Rijli FM (1997) In vivo
functional analysis of the Hoxa-1 3’ retinoic acid response element (3’RARE). Development.
124:399–410. https://doi.org/10.1080/09593330.2013.765921
Dupé V, Ghyselinck NB, Wendling O, Chambon P, Mark M (1999) Key roles of retinoic acid
receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst
in the mouse. Development. 126:5051–9. https://doi.org/10.1074/jbc.M511523200
Durston AJ, Timmermans JPM, Hage WJ, Hendriks HFJ, de Vries NJ, Heideveld M, Nieuwkoop PD
(1989) Retinoic acid causes an anteroposterior transformation in the developing central nervous
system. Nature 340:140–144. https://doi.org/10.1038/340140a0
Edwards MK, McBurney MW (1983) The concentration of retinoic acid determines the differentiated cell types formed by a teratocarcinoma cell line. Dev Biol 98:187–91
El Robrini N, Etchevers HC, Ryckebüsch L, Faure E, Eudes N, Niederreither K, Zaffran S, Bertrand
N (2016) Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple
cell lineages. Dev Dyn 245:388–401. https://doi.org/10.1002/dvdy.24357
Emoto Y, Wada H, Okamoto H, Kudo A, Imai Y (2005) Retinoic acid-metabolizing enzyme Cyp26a1
is essential for determining territories of hindbrain and spinal cord in zebrafish. Dev Biol 278:415–
427. https://doi.org/10.1016/J.YDBIO.2004.11.023
Feng L, Hernandez RE, Waxman JS, Yelon D, Moens CB (2010) Dhrs3a regulates retinoic acid
biosynthesis through a feedback inhibition mechanism. Dev Biol 338:1–14. https://doi.org/10.
1016/j.ydbio.2009.10.029