96
M. Maden
Fig. 4.4 Summary of the distribution of the RA synthetic enzymes. (RALDH2 or RDH10) in
green, the RA metabolizing enzymes (CYP26B1) in red in limb/fins buds (2nd and 3rd columns),
the effects of excess RA (4th and 5th columns) and the effects of removing RA (6th and 7th columns)
on all the vertebrate fin or limb buds discussed in this chapter. Nd = no data. P = posterior, A =
anterior, PAP = double posterior limb
Amphibian Limb Development
There have been remarkably few experiments on RA and amphibian limb development, probably because molecular tools for investigation are lacking even though the
embryos themselves are in plentiful supply and the limb buds are highly accessible.
M. Maden
Fig. 4.4 Summary of the distribution of the RA synthetic enzymes. (RALDH2 or RDH10) in
green, the RA metabolizing enzymes (CYP26B1) in red in limb/fins buds (2nd and 3rd columns),
the effects of excess RA (4th and 5th columns) and the effects of removing RA (6th and 7th columns)
on all the vertebrate fin or limb buds discussed in this chapter. Nd = no data. P = posterior, A =
anterior, PAP = double posterior limb
Amphibian Limb Development
There have been remarkably few experiments on RA and amphibian limb development, probably because molecular tools for investigation are lacking even though the
embryos themselves are in plentiful supply and the limb buds are highly accessible.