Chapter 9
Metal Nanoparticles for Hydrogen
Isotope Exchange
A. Palazzolo, J. M. Asensio, D. Bouzouita, G. Pieters, S. Tricard,
and B. Chaudret
Abstract Since the mid-1990s Hydrogen Isotope Exchange (HIE), consisting in the
direct exchange of protium with its isotopes, has witnessed an enormous development
(Atzrodt et al. in Angew Chem Int Ed, 57:3022–3047, 2018, [1], Atzrodt in Angew
Chem Int Ed, 46:7744–7765, 2007, [2]). HIE reactions can nowadays be performed
on a plethora of organic compounds by using both homogeneous and heterogeneous
catalysis. Molecular catalysts remain the most commonly used due to their high
reliability (Atzrodt et al. in Angew Chem Int Ed, 57:3022–3047, 2018, [1]). However,
metallic nanoparticles have started attracting the attention of the scientific community
(Asensio et al. in Chem Rev, 120:1042–1084, 2020, [3]) because of their interesting
characteristics such as:
1. their reactivity in between homogeneous and heterogeneous catalysts,
2. the possibility to deeply influence their chemical properties by varying the
stabilizing agent,
3. the non-negligible advantages of (generally) simple workup procedures.
In this chapter, we will give an overview of the recent advances in HIE. First, we will
describe the main applications of protium isotopes. Then, we will briefly discuss
the main advances in catalytic HIE reactions in both homogeneous and heterogeneous phase. Finally, we will summarize the examples of HIE catalyzed by metallic
nanoparticles that have been described in the literature.
Keywords Hydrogen Isotope Exchange · Catalytic deuteration · C-H activation ·
H-H activation · Metal nanoparticles
A. Palazzolo · G. Pieters
SCBM, CEA, Université Paris Saclay, F-91191 Gif-sur-Yvette, France
J. M. Asensio (B) · D. Bouzouita · S. Tricard · B. Chaudret
LPCNO, INSA, CNRS, Université de Toulouse, 135, Avenue de Rangueil, F-31077 Toulouse,
France
e-mail: asensior@insa-toulouse.fr
© Springer Nature Switzerland AG 2020
P. W. N. M. van Leeuwen and C. Claver (eds.), Recent Advances in Nanoparticle Catalysis,
Molecular Catalysis 1, https://doi.org/10.1007/978-3-030-45823-2_9
281
Metal Nanoparticles for Hydrogen
Isotope Exchange
A. Palazzolo, J. M. Asensio, D. Bouzouita, G. Pieters, S. Tricard,
and B. Chaudret
Abstract Since the mid-1990s Hydrogen Isotope Exchange (HIE), consisting in the
direct exchange of protium with its isotopes, has witnessed an enormous development
(Atzrodt et al. in Angew Chem Int Ed, 57:3022–3047, 2018, [1], Atzrodt in Angew
Chem Int Ed, 46:7744–7765, 2007, [2]). HIE reactions can nowadays be performed
on a plethora of organic compounds by using both homogeneous and heterogeneous
catalysis. Molecular catalysts remain the most commonly used due to their high
reliability (Atzrodt et al. in Angew Chem Int Ed, 57:3022–3047, 2018, [1]). However,
metallic nanoparticles have started attracting the attention of the scientific community
(Asensio et al. in Chem Rev, 120:1042–1084, 2020, [3]) because of their interesting
characteristics such as:
1. their reactivity in between homogeneous and heterogeneous catalysts,
2. the possibility to deeply influence their chemical properties by varying the
stabilizing agent,
3. the non-negligible advantages of (generally) simple workup procedures.
In this chapter, we will give an overview of the recent advances in HIE. First, we will
describe the main applications of protium isotopes. Then, we will briefly discuss
the main advances in catalytic HIE reactions in both homogeneous and heterogeneous phase. Finally, we will summarize the examples of HIE catalyzed by metallic
nanoparticles that have been described in the literature.
Keywords Hydrogen Isotope Exchange · Catalytic deuteration · C-H activation ·
H-H activation · Metal nanoparticles
A. Palazzolo · G. Pieters
SCBM, CEA, Université Paris Saclay, F-91191 Gif-sur-Yvette, France
J. M. Asensio (B) · D. Bouzouita · S. Tricard · B. Chaudret
LPCNO, INSA, CNRS, Université de Toulouse, 135, Avenue de Rangueil, F-31077 Toulouse,
France
e-mail: asensior@insa-toulouse.fr
© Springer Nature Switzerland AG 2020
P. W. N. M. van Leeuwen and C. Claver (eds.), Recent Advances in Nanoparticle Catalysis,
Molecular Catalysis 1, https://doi.org/10.1007/978-3-030-45823-2_9
281