2. Centella MH, Arevalo-Gallegos A, Parra-Saldivar R, Iqbal HM (2017) Marine-derived bioactive compounds for value-added applications in bio-and non-bio sectors. J Clean Prod
168:1559–1565
3. Liu L, Pohnert G, Wei D (2016) Extracellular metabolites from industrial microalgae and their
biotechnological potential. Mar Drugs 14(10):191
4. Suganya T, Varman M, Masjuki HH, Renganathan S (2016) Macroalgae and microalgae as a
potential source for commercial applications along with biofuels production: a biorefinery
approach. Renew Sustain Energy Rev 55:909–941
5. de Morais MG, Vaz BD, de Morais EG, Costa JA (2015) Biologically active metabolites
synthesized by microalgae. Biomed Res Int 2015:835761
6. Singh R, Parihar P, Singh M, Bajguz A, Kumar J, Singh S et al (2017) Uncovering potential
applications of cyanobacteria and algal metabolites in biology, agriculture and medicine:
current status and future prospects. Front Microbiol 8:515
7. Kraan S (2012) Algal polysaccharides, novel applications and outlook. In: Chang C-F (ed)
Carbohydrates – comprehensive studies on glycobiology and glycotechnology. IntechOpen,
Rijeka
8. Borowitzka MA (2013) High-value products from microalgae – their development and
commercialisation. J Appl Phycol 25(3):743–756
9. Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and
legislation. J Appl Phycol 23(3):543–597
10. Ko SC, Lee SH, Ahn G, Kim KN, Cha SH, Kim SK, Jeon BT, Park PJ, Lee KW, Jeon YJ (2012)
Effect of enzyme-assisted extract of Sargassum coreanum on induction of apoptosis in HL-60
tumor cells. J Appl Phycol 24(4):675–684
11. Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2011) Microwaveassisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed. Carbohydr
Polym 86(3):1137–1144
12. Wang B, Tong GZ, Qu YL, Li L (2011) Microwave-assisted extraction and in vitro antioxidant
evaluation of polysaccharides from Enteromorpha prolifera. Appl Mech Mater 79:204–209
13. Ibañez E, Herrero M, Mendiola JA, Castro-Puyana M (2012) Extraction and characterization of
bioactive compounds with health benefits from marine resources: macro and micro algae,
cyanobacteria, and invertebrates. In: Hayes M (ed) Marine bioactive compounds. Springer,
Boston, pp 55–98
14. Vera J, Castro J, Gonzalez A, Moenne A (2011) Seaweed polysaccharides and derived
oligosaccharides stimulate defense responses and protection against pathogens in plants. Mar
Drugs 9(12):2514–2525
15. Liu QM, Xu SS, Li L, Pan TM, Shi CL, Liu H, Cao MJ, Su WJ, Liu GM (2017) In vitro and
in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis.
Carbohydr Polym 165:189–196
16. Kang Y, Li H, Wu J, Xu X, Sun X, Zhao X, Xu N (2016) Transcriptome profiling reveals the
antitumor mechanism of polysaccharide from marine algae Gracilariopsis lemaneiformis. PLoS
One 11(6):e0158279
17. Fan S, Zhang J, Nie W, Zhou W, Jin L, Chen X, Lu J (2017) Antitumor effects of polysaccharide from Sargassum fusiforme against human hepatocellular carcinoma HepG2 cells. Food
Chem Toxicol 102:53–62
18. Yasuhara-Bell J, Lu Y (2010) Marine compounds and their antiviral activities. Antiviral Res 86
(3):231–240
19. Bandyopadhyay SS, Navid MH, Ghosh T, Schnitzler P, Ray B (2011) Structural features and
in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica. Phytochemistry
72(2–3):276–283
20. Jiménez-Escrig A, Gómez-Ordóñez E, Rupérez P (2015) Infrared characterisation, monosaccharide profile and antioxidant activity of chemical fractionated polysaccharides from the edible
seaweed sugar Kombu (Saccharina latissima). Int J Food Sci Technol 50(2):340–346
172
S. Sinha et al.
168:1559–1565
3. Liu L, Pohnert G, Wei D (2016) Extracellular metabolites from industrial microalgae and their
biotechnological potential. Mar Drugs 14(10):191
4. Suganya T, Varman M, Masjuki HH, Renganathan S (2016) Macroalgae and microalgae as a
potential source for commercial applications along with biofuels production: a biorefinery
approach. Renew Sustain Energy Rev 55:909–941
5. de Morais MG, Vaz BD, de Morais EG, Costa JA (2015) Biologically active metabolites
synthesized by microalgae. Biomed Res Int 2015:835761
6. Singh R, Parihar P, Singh M, Bajguz A, Kumar J, Singh S et al (2017) Uncovering potential
applications of cyanobacteria and algal metabolites in biology, agriculture and medicine:
current status and future prospects. Front Microbiol 8:515
7. Kraan S (2012) Algal polysaccharides, novel applications and outlook. In: Chang C-F (ed)
Carbohydrates – comprehensive studies on glycobiology and glycotechnology. IntechOpen,
Rijeka
8. Borowitzka MA (2013) High-value products from microalgae – their development and
commercialisation. J Appl Phycol 25(3):743–756
9. Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and
legislation. J Appl Phycol 23(3):543–597
10. Ko SC, Lee SH, Ahn G, Kim KN, Cha SH, Kim SK, Jeon BT, Park PJ, Lee KW, Jeon YJ (2012)
Effect of enzyme-assisted extract of Sargassum coreanum on induction of apoptosis in HL-60
tumor cells. J Appl Phycol 24(4):675–684
11. Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2011) Microwaveassisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed. Carbohydr
Polym 86(3):1137–1144
12. Wang B, Tong GZ, Qu YL, Li L (2011) Microwave-assisted extraction and in vitro antioxidant
evaluation of polysaccharides from Enteromorpha prolifera. Appl Mech Mater 79:204–209
13. Ibañez E, Herrero M, Mendiola JA, Castro-Puyana M (2012) Extraction and characterization of
bioactive compounds with health benefits from marine resources: macro and micro algae,
cyanobacteria, and invertebrates. In: Hayes M (ed) Marine bioactive compounds. Springer,
Boston, pp 55–98
14. Vera J, Castro J, Gonzalez A, Moenne A (2011) Seaweed polysaccharides and derived
oligosaccharides stimulate defense responses and protection against pathogens in plants. Mar
Drugs 9(12):2514–2525
15. Liu QM, Xu SS, Li L, Pan TM, Shi CL, Liu H, Cao MJ, Su WJ, Liu GM (2017) In vitro and
in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis.
Carbohydr Polym 165:189–196
16. Kang Y, Li H, Wu J, Xu X, Sun X, Zhao X, Xu N (2016) Transcriptome profiling reveals the
antitumor mechanism of polysaccharide from marine algae Gracilariopsis lemaneiformis. PLoS
One 11(6):e0158279
17. Fan S, Zhang J, Nie W, Zhou W, Jin L, Chen X, Lu J (2017) Antitumor effects of polysaccharide from Sargassum fusiforme against human hepatocellular carcinoma HepG2 cells. Food
Chem Toxicol 102:53–62
18. Yasuhara-Bell J, Lu Y (2010) Marine compounds and their antiviral activities. Antiviral Res 86
(3):231–240
19. Bandyopadhyay SS, Navid MH, Ghosh T, Schnitzler P, Ray B (2011) Structural features and
in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica. Phytochemistry
72(2–3):276–283
20. Jiménez-Escrig A, Gómez-Ordóñez E, Rupérez P (2015) Infrared characterisation, monosaccharide profile and antioxidant activity of chemical fractionated polysaccharides from the edible
seaweed sugar Kombu (Saccharina latissima). Int J Food Sci Technol 50(2):340–346
172
S. Sinha et al.