F42-3 was obtained from the soft coral Lobophytum crassum collected from Sanya
National Coral Reef Reserve. Liquid GPY medium fermentation of this fungus
yielded a 12-membered lactone, (5S,6S)-dihydroxylasiodiplodin (9) [17]. Thirteen
12-membered macrolides, dendrodolides AÀM (10–22), were isolated from the
solid agar medium fermentation of Dendrodochium sp., a fungus associated with
the sea cucumber Holothuria nobilis, which was collected in the South China Sea.
Dendrodolides AÀE, GÀI, K, and L (10–14, 16–18, 20, and 21) exhibited weak
growth inhibitory activity against SMMC-7721 and HCT116 tumor cells, whereas
none of the isolated compounds displayed activity against A549 tumor cells
(Fig. 1) [18].
O
O
OH
O
OH
O
O
1 (cochliomycin A)
O
OH
O
O
OH
O
O
2 (cochliomycin B)
O
O
OH
O
OH
Cl
OH
OH
3 (cochliomycin C)
O
O
OH
O
OH
OH
O
4 ((4R,5S)-cochliomycin D)
5 ((4S,5R)-cocchliomycin E)
6 ((4R,5R)-cochliomycin F)
O
O
OH
O
OH
OH
OH
Br
7 R = H (5-bromozeaenol)
8 R = Br (3,5-dibromozeaenol)
R
O
O
O
OH
OR
10 R = Me (dendrodolide A)
12 R = H (dendrodolide C)
O
O
O
OH
OR
11 R = Me (dendrodolide B)
13 R = H (dendrodolide D)
4
5
O
O
O
HO
OH
OH
9 ((5S,6S)-dihydroxylasiodiplodin)
O
O
O
OH
14 (dendrodolide E)
O
O
OH
OH
15
 (dendrodolide F)
18
(dendrodolide I)
O
O
OH
OH
16
 (dendrodolide G)
19
(dendrodolide J)
O
O
OH
OH
O
17 (dendrodolide H)
O
O
OH
OH
OH
O
O
OH
O
O
O
OH
O
O
20 (dendrodolide K)
21 (dendrodolide L)
22 (dendrodolide M)
è
è
Fig. 1 Structures of macrolides
84
Z. Liu et al.