7 Alkaloids
7.1 Indole Alkaloids
Seven cytochalasans, cytoglobosins AÀG (471–477) (Fig. 27), were obtained from
the liquid potato dextrose broth medium cultivation of Chaetomium globosum
QEN-14, an endophyte derived from the green alga Ulva pertusa collected on the
Qingdao coastline. Cytoglobosins C and D (473 and 474) exhibited cytotoxicity
against the A549 cell line with IC 50 values of 2.3 and 2.6 μM [146]. The fungus
Penicillium sp. AS-79 was isolated from fresh tissue of the sea anemone
Haliplanella luciae that was also sourced from the Qingdao coastline. Fermentation
N
NH
N
N
H
HN
O
O
O
O O
459 R = Me (versicoloritid A)
460 R = H (versicoloritid B)
461 R = CH 2 OH (versicoloritid C)
R
462 R = H (clavatustide A)
463 R = Me (clavatustide B)
O
NH
HN
N
O
O
O
O
R
NH
NH
N
H
HN
H
N
O
O
O
O
O
464 (clavatustide C)
O
NH
O
NH
O
HN
O
N
O
465
O
O
NH
O
NH
O
HN
O
H
N
O
NH
O
466 (oryzamide A)
O
O
NH
O
NH
O
HN
O
H
N
O
NH
O
OH
467 (oryzamide B)
O
O
NH
O
NH
O
HN
O
H
N
O
NH
O
468 (oryzamide C)
S
O
O
NH
O
NH
O
HN
O
H
N
O
NH
O
469 (oryzamide D)
470 (oryzamide E, epimer of 469
at sulfur atom)
S
O
Fig. 26 Structures of peptides (part 2)
124
Z. Liu et al.