epidermidis with MIC values of 12.5 μM against both bacteria [138]. Fermentation
on solid rice medium of Aspergillus versicolor, isolated from the gorgonian
Pseudopterogorgia sp. collected in the South China Sea, yielded a cyclic
tetrapeptide, versicotide D (454) and two cyclic pentapeptides, versicotides E and
NH
N
O
O
NH
O
N
O
HN
HN
O
O
457 (aspersymmetide A)
NH
O
N
H
O
HN
N
O
O
OH
458 (asperterrestide A)
NH
O
O
NH
O
O
NH
NH
O
O
HO
NH
O
O
N
H
O
O
N
H
NH
O
O
HO
444 (aspergillipeptide B)
443 (aspergillipeptide A)
NH
O
O
N
H
O
O
N
H
NH
O
O
OH
HO
445 (aspergillipeptide C)
HN
HN
N
NH
N
O
O
O
O
O
O
O
HO
446 (aspergillipeptide D)
N
H
H
N
COOH
O
O
NH 2
HO
NH
447 (aspergillipeptide E)
N
H
H
N
O
O
NH 2
HO
N
H
O
COOH
448 (aspergillipeptide F)
449 (aspergillipeptide G)
N
H
H
N
O
O
NH 2
HO
O
N
H
NH 2
O
O
N
OH
OH
NH O
H
N
O
NH
H
N
O
O
450 (asperpeptide A)
N
N
N
N
N
H
H
N
O
S
O
O
O
O
O
O
451 (penilumamide C)
O
N
N
N
N
N
H
H
N
O
O
O
NH 2
O
O
452 (penilumamide D)
N
N
N
N
N
H
H
N
O
S
O
O
OMe
O
O
453 (penilumamide B)
O
O
O
O
N
N
H
N
N
H
N
H
N
HN
N
NH
O
O O
O
O
454 (versicotide D)
455 (versicotide E)
N
H
N
NH
H
N
N
O
O O
O
O
456 (versicotide F)
Fig. 25 Structures of peptides (part 1)
122
Z. Liu et al.