medium fermentation of Xylariaceae sp. yielded 4-(hydroxymethyl)-3-methoxy-5methylcyclopent-2-enone (164) [56]. The fungi Penicillium citrinum SCSGAF0052
and Aspergillus sclerotiorum SCSGAF0053 were obtained from the gorgonian
Muricella flexuosa collected from Sanya, Hainan Province. Co-culture of both
fungi in liquid glucose-starch-peptone medium with the addition of sea salt yielded
sclerotiorumins A and B (165 and 166) [65]. Versicolactones A and B (167 and 168)
were isolated from the liquid sorbitol-maltose-yeast extract medium fermentation of
O
O
HO
HO
O
OH
O
OH
O
HO
HO
O
O
O
O
HO
O
O
HO
O
O O
O
O
O
O
O
HO
O
O
162 (penicitrinol G)
163 (penicitrinol H)
164
165 (sclerotiorumin A)
166 (sclerotiorumin B)
O
O
OH
OH
O
OH
OH
O
167 (versicolactone A)
168 (versicolactone B)
O
HO
OH
OH
169 (pestalotiol A)
HO
O
HO
OH
O
HO
O
O
HO
O
O
HO
O
O
O
R
O
OH
O
170 (5-hydroxycyclopenicillone)
171 (hypofuran A)
172 (hypofuran B)
173 R = H (hypocrenone A)
174 R = OH (hypocrenone B)
175 (hypocrenone C)
OH
HO
R 1
R 2 R 3
176 R 1 = OH, R 2 + R 3 = O (dendrodochol A)
177 R 1 = R 2 = OH, R 3 = H (dendrodochol B)
178 R 1 = R 3 = H, R 2 = OH (dendrodochol C)
O
OH
HO
HO
OH
179 (dendrodochol D)
O
OH
O
180 (alterbrasone)
O
OH
OH
O
OH
O
O
HO
O
HO
OH
181 (penicillar A)
182 (penicillar B)
183 (penicillar C)
184 (penicillar D)
185 (penicillar E)
O
HO
O
O
O
HO
O
O
O
O
O
OH
187 (aspericin B)
188 (aspericin C)
186 (aspericin A)
Fig. 10 Structures of other polyketides
Secondary Metabolites from Marine-Derived Fungi from China
99