Two sorbicillinoid analogues, (4
0 Z )-sorbicillin (150) and (2S)-2,3-dihydro-7hydroxy-6-methyl-2-[(E)-prop-1-enyl]-chroman-4-one (151), were obtained from
the GPY liquid medium fermentation of Trichoderma sp. Compound 151 showed
cytotoxicity against the MCF-7 human breast cancer cell line with an IC 50 value of
7.8 μM [62]. The biomalt solid agar medium fermentation of Torula herbarum, as
obtained from the viscera of the sea hare Notarchus leachii cirrosus collected from
Beihai, Guangxi Province, yielded the novel heptaketide, herbarone (152), as well as
ent-astropaquinones B and C (153 and 154) [63]. The fungus Cochliobolus lunatus
TA26–46 was obtained from the fresh inner part of the sea anemone Palythoa
haddoni collected from the Weizhou coral reef in the South China Sea. From starch
medium fermentation of this fungus, a series of diethylene glycol phthalate esters,
cochphthesters AÀG (155–161), were isolated, representing the first examples of
naturally occurring phthalate ester oligomers (Fig. 9) [64].
HO
OH
R 2
HO
OH
R 2
HO
OH
OH
HO
OH
OH
HO
OH
OH
137 R
1 = H, R
2 = OH (hansfordiol A)
138 R
1 + R
2 = O (hansfordiol B)
139 (hansfordiol C)
143 (hansfordiol G)
140 (hansfordiol D)
144 R 1 = R 2 = H (hansfordiol H)
145 R
1 = Cl, R
2 = H (hansfordiol I)
146 R
1 = Cl, R
2 = Me (hansfordiol J)
OR 2
HO
OH
O
Cl
R 1
R 1
R 1
141 R 1 = H, R 2 = OH (hansfordiol E)
142 R 1 + R 2 = O (hansfordiol F)
OH
O
OH
OH
OH
O
OH
OH
OH
OR
OH
O
OH
OH
OH
Cl
OH
O
OH
O
O
HO
O
126 (varioxiranol A)
127 R = H (varioxiranol B)
128 R = Me (varioxiranol C)
129 (varioxiranol D)
130 (varioxiranol E)
OH
CHO
OH
OH
OH
OH
OH
O
OH
OH
O
OH
O
132 (heterocornol A)
133 (heterocornol B)
134 R 1 = R 2 = H
(heterocornol C)
135 R 1 + R 2 = O
(heterocornol D)
136 (heterocornol E)
CHO
O
OH
O
131
R 1
R 2
Fig. 8 Structures of other aromatic polyketides (part 2)
Secondary Metabolites from Marine-Derived Fungi from China
97
0 Z )-sorbicillin (150) and (2S)-2,3-dihydro-7hydroxy-6-methyl-2-[(E)-prop-1-enyl]-chroman-4-one (151), were obtained from
the GPY liquid medium fermentation of Trichoderma sp. Compound 151 showed
cytotoxicity against the MCF-7 human breast cancer cell line with an IC 50 value of
7.8 μM [62]. The biomalt solid agar medium fermentation of Torula herbarum, as
obtained from the viscera of the sea hare Notarchus leachii cirrosus collected from
Beihai, Guangxi Province, yielded the novel heptaketide, herbarone (152), as well as
ent-astropaquinones B and C (153 and 154) [63]. The fungus Cochliobolus lunatus
TA26–46 was obtained from the fresh inner part of the sea anemone Palythoa
haddoni collected from the Weizhou coral reef in the South China Sea. From starch
medium fermentation of this fungus, a series of diethylene glycol phthalate esters,
cochphthesters AÀG (155–161), were isolated, representing the first examples of
naturally occurring phthalate ester oligomers (Fig. 9) [64].
HO
OH
R 2
HO
OH
R 2
HO
OH
OH
HO
OH
OH
HO
OH
OH
137 R
1 = H, R
2 = OH (hansfordiol A)
138 R
1 + R
2 = O (hansfordiol B)
139 (hansfordiol C)
143 (hansfordiol G)
140 (hansfordiol D)
144 R 1 = R 2 = H (hansfordiol H)
145 R
1 = Cl, R
2 = H (hansfordiol I)
146 R
1 = Cl, R
2 = Me (hansfordiol J)
OR 2
HO
OH
O
Cl
R 1
R 1
R 1
141 R 1 = H, R 2 = OH (hansfordiol E)
142 R 1 + R 2 = O (hansfordiol F)
OH
O
OH
OH
OH
O
OH
OH
OH
OR
OH
O
OH
OH
OH
Cl
OH
O
OH
O
O
HO
O
126 (varioxiranol A)
127 R = H (varioxiranol B)
128 R = Me (varioxiranol C)
129 (varioxiranol D)
130 (varioxiranol E)
OH
CHO
OH
OH
OH
OH
OH
O
OH
OH
O
OH
O
132 (heterocornol A)
133 (heterocornol B)
134 R 1 = R 2 = H
(heterocornol C)
135 R 1 + R 2 = O
(heterocornol D)
136 (heterocornol E)
CHO
O
OH
O
131
R 1
R 2
Fig. 8 Structures of other aromatic polyketides (part 2)
Secondary Metabolites from Marine-Derived Fungi from China
97