EV71 virus, with an IC 50 value of 27.7 μM, and was compared to the positive control
ribavirin (IC 50 418.0 μM ) [53]. The fungus Arthrinium sp. was isolated from a piece
of fresh tissue of the gorgonian Anthogorgia caerulea collected from the South
China Sea. Cultivation of this fungus in GPY seawater liquid medium gave (+)-5chlorogriseofulvin (114), exhibiting lethality against the brine shrimp Artemia salina
R 1 R 2 OH
O
O
OH
OH
R 2
O
OH
O
101 R
1 = H, R
2 = OMe (cladosporol F)
102 R
1 = OMe, R
2 = H (cladosporol G)
105 R
1 = H, R
2 = OH (cladosporol J)
103 R
1 + R
2 = O (cladosporol H)
104 R
1 = H, R
2 = OH (cladosporol I)
R 1
O
OH
OH O
OH
OH
OH
O
OH
OH O
OH
OH
OH
OH
OH
O
O
HO
HO
106 (7-epi-8-hydroxyaltertoxin I)
107 (6-epi-stemphytriol)
108
OH
O
O
O
HO
109 (pleosporallin E)
O
O
Cl
O
Cl
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
HO
O
OH
HO
O
O
HO
O
OH
HO
OH
OH
OH
O
O
O
O
O
AcO
HO
HO
OH
OH O
HO
OH O
HO
OH O
HO
OH O
O
S
O
O
O
HO
114 ((+)-5-chlorogriseofulvin)
115 (aspergilone A)
116 (aspergilone B)
117 (penicitrinol F)
118 (7-carboxypenicitrinol C)
119
120
122 (communol D) 123 (communol E) 124 (communol F) 125 (communol G)
OH
O
110 (dichotone A)
O
O
OH
111 (dichotone B)
HO
OH
112 (dichocetide A)
O
HO
HO
OAc
OH
O
O
O
O
113 (pestalotiolide A)
121 (communol C)
O
OH
OH
HO
OH O
O
O
Fig. 7 Structures of other aromatic polyketides (part 1)
Secondary Metabolites from Marine-Derived Fungi from China
95