N
N
S
O
NH 2
N
HN
S
O
O CH 3
SIRT1: 4 nM
SIRT2: 1 nM
SIRT3: 7 nM
Thieno[3,2-d]pyrimidine-6-carboxamide
derivative (49)
N
HN
S
N
N
O
H 3 C
O
ICL-SIRT078 (50)
SIRT2: 170nm- 4μΜ
N
Br
O
CH 3
O
CH 3
O
O
H 3 C
SDX-437 (51)
SIRT1:SIRT2: 700 nM
N
N
N
S
S
N
N
S
S
N N
N
F
F
Triazole-dithiocarbate derivates (53)
SIRT1:1.08 μΜ
O
O
N
H
O
H
N
O
OH
OH
5-(3-(furan-2-carboxamido)benzamido)2-hydroxybenzoic acid (54)
SIRT1:1578 μΜ
SIRT2: 751 μΜ
SIRT6: 89 μΜ
HN
N
H
O
S
O
SIRT1: 13 μΜ
SIRT2: 9 μΜ
Thiobarbiturate (52)
H 3 C
H 3 C
CH 3
O
N
H
N
H
N
H
S
Tenovin-6 (47)
SIRT1: 21 μΜ
SIRT2: 10 μΜ
SIRT3: 67 μΜ
O
N
H
N
H
NH
S
SIRT1: >90 μΜ
SIRT2: 22 μΜ
Cl
Cl
O
Tenovin-D3 (48)
O
O
N
H 3 C
CH 3. HCl
H 3 C
CH 3
H 3 C
O
O
O
H 3 C
O
CH 3
CH 3
CH 3
CH 3
CH 3
CH 3
O
HO
CH 3
Aristoforin (55)
SIRT1: 7 μΜ
SIRT2: 21 μΜ
N
H 3 C
CH 3
Fig. 11 The structures of various sirtuin inhibitors and their IC 50 values
74
M. Rahnasto-Rilla et al.