PRMT5, 178
PRMT6, 181
PRMT7, 183
PRMT8, 184
PRMT9, 185
Proline-tryptophan-tryptophan-proline domain
(PWWP), 340, 371, 372
Prostate cancer, 60, 68, 101, 105, 112, 126, 166,
181, 186, 201, 207, 225, 272, 305, 341,
350, 354, 411
Protein arginine deiminases (PADs), 162
Protein arginine methyltransferase (PRMTs),
126, 159–183, 265, 465
Protein kinase C (PKC) inhibitors, 59
Protein lysine methyltransferases (PKMTs),
128, 135, 143, 465, 468
Pr-SNF, 143
Pseudomonas aeruginosa, 20
PU139, 110
Pyrazolo[1,5-a]pyrimidin-7(4H )-one, 241
Pyridoisothiazolones, 110
Pyrroloquinoxalines, 77, 81
Q
Quantitation, 487
Quercetin, 77
Quisinostat, 8
R
Reactive oxygen species (ROS), 79
Reduced representation bisulfite sequencing
(RRBS), 505
Resminostat, 8
Resveratrol, 76–79
RG108, 264
RG119-1, 264
Ribonucleotide reductase, 7
Ricolinostat, 9, 10, 19, 20
Rituximab, 18
RNA therapy, 401
Romidepsin, 12
Royal Family domain, 339
S
Salermide, 64
Schistosoma mansoni, 20, 461
SDX437, 73
Selisistat, 67
Sequencing, 487
SET and MYND domain-containing (SMYD)
family, 141
SETs, 123
SETD1A/1B, 138
SETD2 (KMT3A/SET2), 143
SETD7 (SET9, SET7/9, KMT7), 140, 469
SETD8, 144
SETDB1 (ESET/KMT1E), 129
SGC110 (guadecitabine), 263
SGC0946, 136
SGF29, 349
SGI-1027, 264
Sickle cell disease (SCD), 19, 126, 202
SID49645275, 265
Sinefungin, 163
Single-molecule real-time (SMRT) sequencing,
511
SirReal2, 70
Sirtinol, 64
Sirtuins (SIRT1–7), 4, 30, 55, 432, 459, 463
SIRT1, 55
smHDAC8, 21, 461, 462
SMRT/NCoR, 31
Solid-phase peptide synthesis (SPPS), 35
SP2509, 205
Spinal and bulbar muscular atrophy, 57
Spindlin-1, 361
Spiro-oxazolidinedione, 112
Splitomicin, 65
SRT1460, 79
SRT1720, 77, 79
Stilbamidine, 466
Structural biology, 287
Structure-based drug design, 455
Suberoylanilide hydroxamic acid (SAHA), 7,
32
Sulfobenzoic acids, 64, 71
Sulfonamides, 8, 323, 365–368
Suramin, 72, 353, 354, 465
SUVs, 123, 128
SUV39H1/2, 130
SUV420H1/2, 144
T
T5342129, 204
TAFII250, 293
Tanikolide, 76
α-TAT1, 98, 101
Tazemetostat (EPZ6438), 133
T-cell lymphoma, 7, 12, 14, 18, 44, 214
Tefinostat, 11
566
Index
PRMT6, 181
PRMT7, 183
PRMT8, 184
PRMT9, 185
Proline-tryptophan-tryptophan-proline domain
(PWWP), 340, 371, 372
Prostate cancer, 60, 68, 101, 105, 112, 126, 166,
181, 186, 201, 207, 225, 272, 305, 341,
350, 354, 411
Protein arginine deiminases (PADs), 162
Protein arginine methyltransferase (PRMTs),
126, 159–183, 265, 465
Protein kinase C (PKC) inhibitors, 59
Protein lysine methyltransferases (PKMTs),
128, 135, 143, 465, 468
Pr-SNF, 143
Pseudomonas aeruginosa, 20
PU139, 110
Pyrazolo[1,5-a]pyrimidin-7(4H )-one, 241
Pyridoisothiazolones, 110
Pyrroloquinoxalines, 77, 81
Q
Quantitation, 487
Quercetin, 77
Quisinostat, 8
R
Reactive oxygen species (ROS), 79
Reduced representation bisulfite sequencing
(RRBS), 505
Resminostat, 8
Resveratrol, 76–79
RG108, 264
RG119-1, 264
Ribonucleotide reductase, 7
Ricolinostat, 9, 10, 19, 20
Rituximab, 18
RNA therapy, 401
Romidepsin, 12
Royal Family domain, 339
S
Salermide, 64
Schistosoma mansoni, 20, 461
SDX437, 73
Selisistat, 67
Sequencing, 487
SET and MYND domain-containing (SMYD)
family, 141
SETs, 123
SETD1A/1B, 138
SETD2 (KMT3A/SET2), 143
SETD7 (SET9, SET7/9, KMT7), 140, 469
SETD8, 144
SETDB1 (ESET/KMT1E), 129
SGC110 (guadecitabine), 263
SGC0946, 136
SGF29, 349
SGI-1027, 264
Sickle cell disease (SCD), 19, 126, 202
SID49645275, 265
Sinefungin, 163
Single-molecule real-time (SMRT) sequencing,
511
SirReal2, 70
Sirtinol, 64
Sirtuins (SIRT1–7), 4, 30, 55, 432, 459, 463
SIRT1, 55
smHDAC8, 21, 461, 462
SMRT/NCoR, 31
Solid-phase peptide synthesis (SPPS), 35
SP2509, 205
Spinal and bulbar muscular atrophy, 57
Spindlin-1, 361
Spiro-oxazolidinedione, 112
Splitomicin, 65
SRT1460, 79
SRT1720, 77, 79
Stilbamidine, 466
Structural biology, 287
Structure-based drug design, 455
Suberoylanilide hydroxamic acid (SAHA), 7,
32
Sulfobenzoic acids, 64, 71
Sulfonamides, 8, 323, 365–368
Suramin, 72, 353, 354, 465
SUVs, 123, 128
SUV39H1/2, 130
SUV420H1/2, 144
T
T5342129, 204
TAFII250, 293
Tanikolide, 76
α-TAT1, 98, 101
Tazemetostat (EPZ6438), 133
T-cell lymphoma, 7, 12, 14, 18, 44, 214
Tefinostat, 11
566
Index