the BAF complex factor BRD9 by heterobifunctional ligands. Angew Chem Int Ed Engl
56(21):5738–5743
139. Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA,
Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner
JE (2018) Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL
ligands. Nat Chem Biol. https://doi.org/10.1038/s41589-018-0010-y
140. Tekel SJ, Haynes KA (2017) Molecular structures guide the engineering of chromatin. Nucleic
Acids Res 45(13):7555–7570. https://doi.org/10.1093/nar/gkx531
Applied Biophysics for Bromodomain Drug Discovery
337
56(21):5738–5743
139. Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA,
Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner
JE (2018) Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL
ligands. Nat Chem Biol. https://doi.org/10.1038/s41589-018-0010-y
140. Tekel SJ, Haynes KA (2017) Molecular structures guide the engineering of chromatin. Nucleic
Acids Res 45(13):7555–7570. https://doi.org/10.1093/nar/gkx531
Applied Biophysics for Bromodomain Drug Discovery
337