Table 1 HAT family members: classification and main biological implications
Protein
name
Gene
names
Cellular
localization
Histone
targets
Nonhistone
targets
Pathology
Ref.
P300/CBP family
KAT3A CREBBP,
CBP
Nucleus
H2A,
H2B
NF-kappaB,
c-myb,
Foxo1
Neurodegenerative diseases:
Rubinstein-Taybi syndrome.
Cancers: acute myeloid leukaemia; acute lymphoid leukaemia;
lung, colon, breast and ovarian
carcinomas; nasopharyngeal
carcinoma; cutaneous squamous cell carcinoma
[40–45]
KAT3B EP300,
P300
Nucleus
H2A,
H2B
NFkappaB, cmyc, p53,
STAT3,
β-catenin,
Foxo1, AR
GNAT family
KAT1
HAT1
Nucleus
H3, H4,
H2A
–
Neurodegenerative diseases.
Cancers: lung, colon, breast,
ovarian, hepatic, gastric and
oesophageal cancers
[15, 67]
KAT2A KAT2A,
GCN5,
GCN5L2
Nucleus
H3, H4,
H2A
CDC6,
CDK9,
cyclin D1,
cyclin E1
and E2F1,
HDM2,
PTEN, cmyc
KAT2B pCAF
Nucleus
H3
p53, CDK9,
c-myc,
Foxo1, AR
KAT9
ELP3
H4,
H2A,
H3
–
α-TAT1 α-TAT1,
MEC17,
C6orf134
Cytosol
Tubulin,
cortactin
MYST family
KAT5
KAT5,
TIP60,
HTATIP
Nucleus
H4,
H2A
ATM,
TRRAP,
p53, E2F1,
c-myc
Neurodegenerative diseases:
genitopatellar syndrome. Cancers: acute myeloid leukaemia;
acute lymphoid leukaemia;
colorectal, gastric, breast, ovarian, hepatocellular and renal
cell carcinomas
[51–53]
KAT6A KAT6A,
MOZ,
MYST3,
RUNXBP
Nucleus
H3
–
KAT6B KAT6B,
MORF,
MOZ2,
MYST4
Nucleus
–
–
KAT7
KAT7,
HBO1,
HBOa,
MYST2
Nucleus
H3, H4
–
KAT8
KAT8,
MOF,
MYST1
H4
96
D. Trisciuoglio and D. Rotili