358
J. Qu and J. Zhang
Table 12.1
Aptamer sequences against AD biomarkers
Targets
Source
Aptamer sequences (5
-3’)
References
Aβ1-40
RNA
UUUACCGUAAGGCCUGUCUUCGUUUGACAGCGGCUUGUUGACCCUCACACUUUGUACCUGCUGCCA
[47]
Aβ1-40
DNA
GCGTAATACGACTCACTATAGGGCGGGGAATTCGAGCTCGGTACCTTTACCGTAAGGCCTGTCTTCGTTTGACAGCGGCTTGTTGACCCTCACAC
TTTGTACCTGCTGCCAACTGCAGGCATGCAAGCTTGG
[48]
Aβ
DNA
CGCACCCGCCCCAACACCACAGGCAGCGGGTGCGGAACTGTGCCTGTGGTTTGGGGC
CCACAGGCACGAGTTCCGCACCCGCTGCCTGTGGTGTTGG GGCGGGTGCGAACTCGTG
[50]
Aβ42
RNA
GGGACGAAGACCAACUGAACUUUGUGGUGGCGGCUACUCGUCUUCUUUUGACUUUGUCCGUGCUGCCACCUUACUUC
[54]
BACE1
DNA
GCAATGGTACGGTACTTCCGTCATCAGCTTGTGATG
TGGATGCGAACTGCAAAAGTGCACGCTACTTTGCTAA
[56]
BACE1
DNA
GTACACGTCGGCCACCTACGCGAAGTGGAAGCCTCATTTG
[57]
tau-381
DNA
GCGGAGCGTGGCAGG
[61–64]
tau-410
DNA
CTTCTGCCCGCCTCCTTCC
GAAGACGGGCGGAGGAAGG
[61]
p-tau
DNA
CAGCACCGTCAACTGAATTGCTTGGTCCTCCCGGGGTTCTGGAAAAGCGTGATGCGATGGAGATGT
[66]
tau-441
RNA
CCGUGUCUUCGUGAGGUCGGUGUCGGCUUGGCAGAAAGGG
[67]
(randomized region in bold)